1.Liensinine attenuates inflammation and oxidative stress in spleen tissue in an LPS-induced mouse sepsis model.
Hanyu WANG ; Yuanhao YANG ; Xiao ZHANG ; Yan WANG ; Hui FAN ; Jinfeng SHI ; Xuelian TAN ; Baoshi XU ; Jingchao QIANG ; Enzhuang PAN ; Mingyi CHU ; Zibo DONG ; Jingquan DONG
Journal of Zhejiang University. Science. B 2023;24(2):185-190
Sepsis is a complex syndrome caused by multiple pathogens and involves multiple organ failure, particularly spleen dysfunction. In 2017, the worldwide incidence was 48.9 million sepsis cases and 11 million sepsis-related deaths were reported (Rudd et al., 2020). Inflammation, oxidative stress, and apoptosis are the most common pathologies seen in sepsis. Liensinine (LIE) is a bisbenzylisoquinoline-type alkaloid extracted from the seed embryo of Nelumbo nucifera. Lotus seed hearts have high content of LIE which mainly has antihypertensive and antiarrhythmic pharmacological effects. It can exert anti-carcinogenic activity by regulating cell, inflammation, and apoptosis signaling pathways (Manogaran et al., 2019). However, its protective effect from sepsis-induced spleen damage is unknown. In this research, we established a mouse sepsis model induced by lipopolysaccharide (LPS) and investigated the protective effects of LIE on sepsis spleen injury in terms of inflammatory response, oxidative stress, and apoptosis.
Mice
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Animals
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Lipopolysaccharides/pharmacology*
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Spleen
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Inflammation
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Apoptosis
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Sepsis
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Oxidative Stress
Result Analysis
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