The incidence of vascular malformations is very low, and its clinical manifestations are infinite in variety, from an asymptomatic birthmark to life-threatening massive bleeding, even to congestive heart failure. The pathogenesis of vascular malformations is still unknown, therefore, its effective treatment is a real challenge. With the development of interventional technology and the accumulation of clinical experience in ethanol embolization, in local direct puncture injection and in endovascular embolization, the ethanol embolization will hopefully become the therapy of first choice for this kind of complicate and intractable disorders.

To review the study progresses in venom protein, peptide and amino acids in natural drug. The study progresses were reviewed on the basis of analying the collected articles. Concerning the distribution, chemical structure, property, pharmacology and toxicity of ricin, abrin, riscotoxin, snake venom, bee venom and buthotoxin. These compounds have certain toxicity and biological activity to animals, It's worth exploiting and utilizing them in conjunction with the achievement in modern chemistry and pharmacology.

Objective To study the methylation status of p16 gene in peripheral blood mononuclear cell (PBMC) of patients with plaque psoriasis, and to study its significance in the pathogenesis of the disease. Methods Thirty-four cases of psoriatic patients and 35 healthy controls were measured for the status of promoter methylation in p16 gene by methylation specific PCR (MSP). A region containing CpG site in p16 gene promoter was amplified by MSP. The severity of psoriasis was evaluated by PASI scores. Results The methylation rates of p16 gene in PBMC were significantly higher (P

This study was designed to assess the effect of implantation site and environment on early in vivo degradation behaviors of poly(L-lactide) (PLLA) and poly(L-lactide-co-glycolide) (PLGA) copolymer. The rods were implanted at two sites in each of 24 New Zealand White rabbits. The first site was within the suprapatellar bursa of the joint cavities (JC) and the second site was in the opposite condyles of femurs (CF). Three rabbits of each group underwent explantation of rods after 4, 8, 12, and 16 weeks. At each interval, measures were taken to evaluate the molecular weight, shear strength, weight loss and thermal properties of PLLA and PLGA. It was found that PLGA degraded slightly faster than PLLA. After 16 weeks, PLLA's initial inherent viscosity of 4.6 decreased to about 3.4 in both implantation sites while that of PLGA decreased from 4.6 to about 2.2. Both PLGA and PLLA showed enough shear strength retention in 16 weeks (> or = 53MPa) within 16 weeks. Autocatalysis mechanism was confirmed by the fact of accelerated weight loss of PLGA after 8 weeks and of PLLA after 12 weeks. The results revealed that PLGA could be a promising candidate material as a replacement of PLLA in internal fixation of bone fractures, and no significant difference of early in vivo degradation behaviors between PLLA and PLGA was observed in regard to different implantation sites in 16 weeks.
Absorbable Implants ; Animals ; Bone Nails ; Female ; Implants, Experimental ; Internal Fixators ; Lactic Acid ; chemistry ; metabolism ; Male ; Polyesters ; Polyglycolic Acid ; chemistry ; metabolism ; Polymers ; chemistry ; metabolism ; Rabbits

Objective To explore the path relationship of working stress , self-esteem and the sense of achievement for acute critical care nurses .Methods Using the method of convenient sampling , a questionnaire survey was conducted on 265 emergency nurses and ICU nurses . The questionnaire included general information , nurse burnout scale , self-esteem scale and nurse stress scale .Results Totals of 265 questionnaires were distributed, and 255 questionnaires were returned , with an effective rate of 96.2%.The scores of stress scale for nurses who worked for one year , two-five years and over five years were (3.03 ±0.40), (3.12 ± 0.54) and (3.06 ±0.39), respectively.There was a significant difference among groups (F=23.534,P=0.00).The scores of self-esteem for nurses who worked for one year , two-five years and over five years were (19.87 ±2.17), (20.19 ±1.98) and (18.93 ±2.87), with a statistically significant difference (F=21.391, P=0.00) .The scores of working achievement for nurses who worked for one year , two-five years and over five years were (4.18 ±1.64), (4.25 ±1.43) and (4.20 ±1.63), and the difference was significant (F =18.733, P=0.00).There was a negative correlation between the critical nurses'working achievement and working stress (r=-0.317, -0.271, -0.211, -0.231, -0.356, respectively;P <0.05), and the working achievement and the self -esteem was positively related (r=0.357,P<0.01).The self-esteem was not completely intermediary between working stress and working achievement , and the indexes of model fitting were χ2/df=1.244,P=0.305, RMSEA=0.019, NFI=0.977, RFI=0.984, IFI=0.987, TLI=0.960, CFI=0.937.Conclusions Self-esteem plays a significant intermediary role between working stress and working achievement for acute and critical care nurses .

Objective To explore the relationship between functioning mechanisms of self-efficacy and perceived social support in stress and maladjustment among intensive nurses .Methods A total of 446 intensive nurses were assessed by general information questionnaire , General Self-efficacy Scale(GSES), Perceived Social Support Scale ( PSSS ) , General Maladjustment Scale ( Gm ) , and Chinese Nurse Stressor Scale ( CNSS ) . Results The scores of Gm were positively correlated with the scores of CNSS (r =0.466,P <0.05), and negatively correlated with the scores of GSES and PSSS ( r=-0.205,-0.333,respectively;P<0.05).Self-efficacy had an obvious effect on mediating between stress and maladjustment ( P <0.05).Perceived social support had an obvious effect on mediating and moderating between stress and maladjustment ( P <0.05). Conclusions Self-efficacy among intensive nurses can mediate the effects of stress on maladjustment .Perceived social support can mediate and adjust the effects of stress on maladjustment .