KAI1 is a recently identified metastasis suppressor gene located at human chromosome 11 p11.2. KAI1 protein is a member of the structurally distinct family of cell surface glycoprotein and belongs to transmembrane 4 protein superfamily. KAI1 expression is down-regulated in many metastatic tumor cells. Down-regulation of KAI1 expression also plays an important role in the genesis and development of gynecological tumor.

Objective To observe the therapeutic effect of Trimetazidine on patients with alcohol cardiomyopathy based on conventional medicine. Methods 46 cases with alcoholic cardiomyopathy were randomly divided into congroup (22 cases) and observation group(24 cases), they were given conventional therapy and additional Trimetazidine for 4 weeks respectively, we estimated therapeutic effect based on 6 min walking experiments, left entricular ejection fraction, and the content of C-reactive protein. Results The results of 6 min walking experiments (543.5 ±69.3) vs (492.7 ± 72.7),left ventricular ejection fraction (44.3 ± 8.6) vs (49.8 ± 9.5) and C-reactive protein content (5.2 ± 0.7) vs (8.9 ± 1.1) in observation group were better than control group. Conclusion Additional Trimetazidine could improve cardiac function by improving cardiacenergy metabolism and anti-inflammatory effect on alcohol cardiomyopathy patients ,Trimetazidine was of great value to generalization.

By analyzing the covariance of maintenance data in Hospital Information System,this paper points out the wrong operations of Hospital Information System and puts forward a series of valid solutions including software improvement,timely communication with users,reinforcement of operator training.

ObjectiveTo observe the effect of rehabilitation training on family caregiver of schizophrenic in rural areas.Methods60 schizophrenic patients in rural area were divided into rehabilitation group and control group. The rehabilitation group and their caregivers received training of family rehabilitation for 12 months. The caregivers in the control group only received interview. Brief Psychiatric Rating Scale (BPRS) and Social Disability Screening Schedule(SDSS) were used to assess the patients before, 6 months and 12 months after training. The self-made caregiver questionnaire was to assess mental knowledge and family harmony of the caregivers.ResultsPsychiatric knowledge and family harmony for caregivers significantly changed in the rehabilitation group after the family rehabilitation training. There were significant differences in the BPRS and SDSS score between the rehabilitation group and the control group.ConclusionThe family rehabilitation training can benefit the rural schizophrenic patients and their caregivers.

Objective To explore the effect of gradual community-based rehabilitation on schizophrenia in the countryside. Methods 60 rural patients with schizophrenias were randomly sampled and divided into two groups: the rehabilitation group and the control group. The patients in the rehabilitation group were intervened with comprehensive rehabilitation by specialist, while those in the control group were intervened with follow-up survey. They were assessed with the Brief Psychiatric Rating Scale (BPRS), Scale for Assessment of Negative Symptoms (SANS) and Social Disability Screening Schedule (SDSS) before and 3, 6, 9, 12, 15, 20 months after the rehabilitation. Results The differences in scores of BPRS, SDSS and SANS were more significant with the time of rehabilitation. Conclusion The outcome of the community-based rehabilitation for schizophrenias may associate with the persistence in the countryside.

Early diagnosis and timely treatment are two critical factors in reducing the cerebral damage and improving prognosis for ischemic stroke patients.The only proved effective way is to intravenously administer recombinant tissue plasminogen activator for thrombolytic therapy.However,the narrow time window restricts its application.One rapid and effective blood test,or auxiliary examinations such as computer tomography which may aid early diagnosis of ischemic stroke would contribute to treatment and intervention promptly,then take a pivotal role for the disease prognosis.Herein,the reported proteins and RNA markers are summarized and analysed in clinical application of acute ischemic stroke likewise.

Paraneoplastic neurological syndromes (PNS) were defined as neurological syndromes associated with cancer.In many cases,autoantibodies against neural antigens expressed by the tumor (paraneoplastic neurological antibody or onconeural antibodies) were detected.The neuronal antibodies,which were associated with syndromes resulting from central nervous system neuronal dysfunction,were classified into two groups according to the location of the antigen:inside the neuron or in the cell membrane.Group Ⅰ antibodies targeted on intracellular antigens and were predominantly dependent on T-cell-mediated responses.Group Ⅱ antibodies recognized neuronal surface antigens and were predominantly dependent on B-cell-mediated responses.Onconeural antibodies were useful diagnostic markers of the brain disease,and in some cases,they might reveal an underlying malignancy.Moreover,the presence of antibodies against surface(group Ⅱ) antigens might predict a more favorable response to immunotherapy than that against intracellular (group Ⅰ) antigens.

OBJECTIVE:To probe into the effects of ?-1bIFN on the development process from the hepatitis gravis to postnecrotic cirrhosis.METHODS:The change of serum liver fibrosis markers and hepatic function were observed in treatment group and control group before and after treatment.RESULTS:(1)In treatment group,all the serum liver fibrosis markers were decreased after treatment and were significantly different from those in control group(P0.05).(2)After treatment,the levels of serum albumin,globulin and count of platelet reverted to normal in treatment group and the levels were significantly different from those in control group(P

Objective: To build a relationship model of perceived academic self-efficacy, learning stress, and learning burnout of high school students. Methods: 674 high school students were surveyed with Learning Stress Scale of High School Students, The Perceived Academic Self -efficacy Scale, Scale of Learning Burnout of High School Students. Results: Learning stress had a direct effect on a low level of learning efficacy, perceived alienation to teacher and physical exhaustion (The direct effect value were -0.22,0.12,0.27). At the same time, perceived basic ability and perceived control partially mediated the impact of learning stress on the low level of learning efficacy, perceived alienation to teacher and physical exhaustion (the mediated effect value were -0.155 and-0.264, 0.066 and 0.299, 0.089 and 0.233). Perceived basic ability and perceived control fully mediated the relationship between learning stress and emotional exhaustion (the mediated effect value were 0.033 and 0.387). Conclusion: The students with a higher level of stress reported suffering more learning burnout than those with a lower level of stress, and vice versa.

OBJECTIVE:To develop a HPLC-ECD method for the determination of scutellarin in human plasma.METH-ODS:The plasma sample injection was performed after protein precipitation by methanol.The mobile phase consisted of 0.083mol? L-1 sodium dihydrogen phosphate-methanol-acetonitrile-tetrahydrofuran(60:30:10:0.4),which was added dropwise with H3PO4 in a ratio of 100:106).The column temperature was under room temperature;the detection voltage was 100mV;the protection voltage was 500mV;the flow rate was 1mL? min-1 and the sample size was 20? L.RESULTS:The calib-ration curve was linear in the range of 20.0～ 400.0?g? L-1(r=0.999 9).The methodological recovery was 96.79% ～ 108.50%.Both the intra-day and inter-day RSD were less than 5%.CONCLUSION:This HPLC-ECD method is accurate,sensitive and simple,and suitable for pharmacokinetic study of scutellarin.