1.Transurethral ultrasonography in the diagnosis and staging of bladder tumor
Chinese Journal of Urology 2001;0(10):-
Objective To evaluate transurethral ultrasonic scanning in the diagnosis and staging of bladder tumor. Methods Form 1996 to 2000 transurethral ultrasonography(TUUS) was carried out for 70 cases of bladder cancer and the findings were compared with cystoscopy,transabdominal ultrasonography(TAUS),CT,MRI and pathological studies. Results The diagnosis rate of TUUS has been 99.1% being better than cystoscopy and TAUS.The accurate staging rate was 100.0% in stage T 1 tumors, 95.8% in stage T 2,82.4% in stage T 3 and 55.6% in stage T 4. Conclusions TUUS can clearly reveal the depth of tumor infiltration and therefore is an important method for the diagnosis and staging of early bladder tumor.
2.A Research on Androgynous Female College Students' Personality Traits,Physical and Psychological Symptom and Adaptation to College Life
Chinese Mental Health Journal 2002;0(11):-
Objective:To explore androgynous female college students' personality traits,physical and psycho- logical symptom and adaptation to college life.Methods:A cluster sample of 1081 female college students was tested with the Chinese Sex Role Inventory (CSBI),NEO Personality Inventory-Revised (NEO-PI-R),Symptom Checklist 90 (SCL-90),and China College Student Adjustment Scale (CCSAS).Results:(1) The percentage of four gender role stereotypes,including masculine,feminine,androgynous and undifferentiated,were 23.8%,24.1%, 25.1%,27.1% respectively.(2) Androgynous female college students' score of extraversion,openness,agreeable- ness,conscientiousness were highest,for example,androgynous female college students' score of extraversion was (3.7?0.4),but androgynous female college students' score (2.1?0.6) of neuroticism was lowest.In contrast,un- differentiated female college students' scores of extraversion (3.1?0.5),openness,agreeableness,conscientious- ness were lowest,androgynous female college students' score (2.8?0.6) of neuroticism was highest.For other gender role stereotypes,female college students' score was between androgynous and undifferentiated.(3) As to all factors of physical and psychological symptom,androgynous female college students' scores were lowest,but undifferentiated fe- male college students' scores were highest.For example,anxiety score of androgynous female college students was (1.4?0.4),and that of undifferentiated female college students was (1.6?0.6);depression score of androgynous female college students was (1.4?0.4),and that of undifferentiated female college students was (1.6?0.6). (4) Androgynous female college students' adjustment of interpersonal relationship (37.6?5.7) was better than that of undifferentiated female college students (29.4?6.5).Other gender role stereotypes' adjustment scores of interper- sonal relationship were between androgynous and undifferentiated female college students.Conclusion:Although an- drngynous female college students' personality trait,physical and psychological symptom and adaptation to college life are better than other gender role stereotypes statistically,these results need more deeply research.
3.Effect of different target plasma concentrations of remifentanil on sedative effect of propofol
Jing XU ; Wenyuan WANG ; Taidi ZHONG
Chinese Journal of Anesthesiology 2010;30(6):648-650
Objective To investigate the effect of different target plasma concentrations (Cp) of remifentanil on sedative effect of propofol. Methods Eighty adult ASA Ⅰ or Ⅱ patients aged 18-60 yr undergoing elective laparoscopic cholecystectomy were randomly assigned into 4 groups (n = 20 each). Anesthesia was induced with TCI of remifentanil (Cp = 2, 4 and 8 ng/ml in group Ⅱ-Ⅳ respectively) and propofol TCI (the initial Cp of propofol was 2 μg/ml in the 4 groups). Then the Cp of propofol increased by 0.5 μg/ml every 1 min until BIS value decreased to 50. BIS value and the Cp of propofol were recorded as the patient lost consciousness.The Cp and consumption of propofol were recorded when BIS value decreased to 50. Results BIS value was significantly increased, while the Cp of propofol was significantly decreased as the patient lost consciousness, and the Cp and consumption of propofol were significantly decreased when BIS value decreased to 50 in group Ⅲ - Ⅳ compared with group Ⅰ (P < 0.05). Conclusion Remifentanil 4 ng/ml is the suitable Cp for anesthesia when combined with propofol.
4.Clinical Study on Combination of Disease and Syndrome and Separated Complex Prescription
Jie WANG ; Lu JING ; Jingbo ZHONG
Journal of Traditional Chinese Medicine 1993;0(03):-
Objective:To probe into clinical therapeutic effects of separated TCM compound recipe Xuefu Zhuyu Decoction for combination of disease and syndrome,so as to further expound the law of TCM recipe formulation.Methods:By using randomized double blind placebo control method,123 cases were randomly divided into Xuefu Zhuyu group,refine Xuefu Zhuyu group,drug-pair group and placebo group.Each ease was administered 10ml each time,thrice daily,4 weeks as one course.Results:The therapeutic effect for angina pectoris of coronary heart disease was in order of Xuefu Zhuyu group,refine Xuefu Zhuyu group,drug-pair group and placebo group(P
5.New idea about the teaching of medical statistics for medical postgraduate students
Runhua WANG ; Jing YI ; Xiaoni ZHONG
Chinese Journal of Medical Education Research 2003;0(04):-
Objective To find out a new teaching pattern of Medical Statistics for medical postgraduate students.Methods To manifest the longitudinal thought of the medical research process from the teaching idea,the teaching content arrangement and the teaching method utilization.Results To discuss the superiority of the new pattern which provides the content frame and the teaching method based on the integrating theory and the practice.Conclusion The teaching reformation of Medical Statistics must be advantageous in improving the learner’s power of the medical scientific research,including selection of the scientific research topic,application of project,the quality control of the project,analysis of the material and inference of the conclusion,paper writing,self-appraisement and achievement evaluation.
6.Expressions and prognostic value of metadherin, E-cadherin, and β-catenin in patients with hepatocellular carcinoma
Xujian CHEN ; Yiyu SHEN ; Jing WANG ; Zhengxiang ZHONG ; Hongjia PAN
Chinese Journal of Hepatobiliary Surgery 2013;19(8):597-600
Objective To study the expressions of metadherin (MTDH),E-cadherin and β-catenin in the tissues of hepatocellular carcinoma (HCC),to investigate the relationship between them and the clinical-pathological features,and to evaluate the prognostic values after surgical resection for hepatocellular carcinoma.Methods The protein expressions of MTDH,E-cadherin and β-catenin were studied by immunohistochemistry in tumor tissues of 107 HCC patients who underwent curative surgical resection.The data were correlated with the clinical-pathological data,tumor free time and recurrence rate.Results Positive expression of MTDH and nuclear β-catenin accumulation were correlated with the Edmondson grade (P<0.05) and decreased E-cadherin expression was correlated with the preoperative serum level of α-fetoprotein (AFP) (P<0.05).All these expressions were associated with a shorter tumor-free survival and a higher recurrence rate (P<0.05).Positive MTDH expression was correlated with decreased E-cadherin expression and nuclear β-catenin accumulation (P<0.05).On Cox regression analysis,MTDH was an independent risk factor of tumour recurrence (RR=3.431,CI=1.254~ 7.318).Conclusions Positive MTDH expression,decreased E-cadherin expression,and nuclear β-catenin accumulation indicated a higher recurrence rate after curative surgical resection for HCC.MTDH was an independent risk factor of recurrence.
7.Up-regulation of Nrf2 pathway and intervention of intracellular redox homeostasis in shikonin-induced A549 cell apoptosis
Chen XIE ; Hanying CHEN ; Jing ZHONG ; Xiaoqin WANG ; Bo ZHANG
Chinese Pharmacological Bulletin 2014;(10):1445-1451
Aim To investigate the roles of intracellu-lar reactive oxygen species ( ROS ) and Nrf2 pathway in shikonin-induced A549 cell apoptosis. Methods The cytotoxicity was analyzed by MTT assay. The ap-optosis of A549 cells was analyzed by both cellular morphological and biochemical methods. The relative changes of the redox marks ( ROS/GSH) were studied by fluorescence assay in the shikonin-treated A549 cells in accompany with the changes of the intracellular redox homeostasis by GSH/GSSG ratio. ROS inhibitor was also employed in the treatment to find the role of ROS in shikonin-induced A549 cell apoptosis. Real-time PCR analysis and ELISA assay were performed as well to determine the role of Nrf2 pathway in the shiko-nin-induced A549 cell apoptosis. Results The IC50 of shikonin on A549 cells was 3. 2 mg·L-1 . The cellu-lar redox homeostasis shifted toward oxidation signifi-cantly in shikonin treatment in a time-dependent man-ner. The expression of the Nrf2 pathway related genes was up-regulated by shikonin ( 3 . 2 mg · L-1 , 8 h ) . The expression of the anti-apoptotic genes was down-regulated , and proapoptotic genes were up-regulated by shikonin (3. 2 mg·L-1, 24h). Futhermore, the inhi-bition of intracellular ROS alleviated the cytotoxicity of shikonin in A549 cells. Conclusion The critical role of shikonin-induced redox imblance in A549 cell, coped with the secondary produced ROS and Nrf2 path-way antioxidants, result in A549 cell apoptosis.
8.A qualitative study of the experience of self-perceived burden in patients with chronic obstructive pulmonary disease
Qin CHEN ; Minyu LIANG ; Jing WANG ; Yingjun FENG ; Tong ZHONG
Chinese Journal of Practical Nursing 2014;30(25):12-15
Objective To explore the experience of self-perceived burden in patients with chronic obstructive pulmonary disease (COPD) and provide evidence for clinical nursing interventions.Methods Indepth interviews were conducted among 17 patients with COPD using phenomenological method of qualitative research.Data were analyzed with the Colaizzi's method.Results 3 themes was identified:self-accusation and guilt,loss of dignity and powerlessness,concern and insecurity.Conclusions Nurses should take the experience of SPB in patients with COPD seriously and take the influence of SPB into account during the process of nursing interventions and evaluation.
9.Evaluating of left atrial remodeling and predicting the efficacy of radiofrequency catheter ablation with atrial fibrillation by speckle tracking imaging
Xiaofang ZHONG ; Weibin HUANG ; Jing WANG ; Jun GUO
Chinese Journal of Ultrasonography 2015;(5):382-386
Objective To evaluate left atrial function dynamic changes before and after radiofrequency catheter ablation (CA)with persistent atrial fibrillation (AF)and predict the maintain sinus rhythm of postoperative atrial fibrillation by speckle tracking imaging.Methods The study was including 45 cases underwent CA with persistent AF(preoperative 1 week,postoperative 24 hours,3 months,6 months)and 25 normal cases.Left atrial function and strain rate were analysed.These index were measured and calculated:the left atrial diameter index (LADI),left atrial area index (LAAI),left atrial maximum volume index (LAVImax)and left atrial ejection fraction(LAEF),left atrial wall strain rate of left ventricular systolie (SRs),left atrial wall strain rate of left ventricular early diastolie (SRe),left atrial systolic strain rate(SRa) and the average of left atrial wall each phase strain rate.Results ① LADI,LAAI,LAVImax were significantly increased;LAEF,SRs,SRe were decreased significantly;SRa were disappeared with AF compared with the control group.②LADI,LAAI,LAVImax decreased gradually,LAEF,SRs,SRe,SRa were gradually increased with the extension of the follow-up time.③Left atrial average SRs predicted maintenance of sinus rhythm with atrial fibrillation after operation of CA(odds ratio=0.607,95% CI=0.417-0.819,correction of P =0.017)was an independent predictor.Conclusions Speckle tracking imaging can quantitative evaluate left atrial function with persistent AF after CA.Left atrial global reservoir function predicts the efficacy of CA.
10.Relationship between C677T polymorphism of methylenetetrahydrofolate reductase gene/G448A polymorphism of β-fibrinogen gene and genetic susceptibility of ischemic stroke
Mulin HU ; Tao LI ; Qin CHEN ; Zhiwei JING ; Zhong WANG
International Journal of Cerebrovascular Diseases 2009;17(3):181-185
Objective To investigate the relationship between the C677T polymor-phism of the methylenetetrahydrofolate reductase (MTHFR) gene/G448A polymorphism of the