1.Complete Mitochondrial Genome of a Tongue Worm Armillifer agkistrodontis.
Jian LI ; Fu Nan HE ; Hong Xiang ZHENG ; Rui Xiang ZHANG ; Yi Jing REN ; Wei HU
The Korean Journal of Parasitology 2016;54(6):813-817
Armillifer agkistrodontis (Ichthyostraca: Pantastomida) is a parasitic pathogen, only reported in China, which can cause a zoonotic disease, pentastomiasis. A complete mitochondrial (mt) genome was 16,521 bp comprising 13 protein-coding genes (PCGs), 22 tRNA genes, 2 rRNA genes, and 1 non-coding region (NCR). A phylogenetic tree drawn with the concatenated amino acid sequences of the 6 conserved PCGs (atp6, cox1-3, and nad2) showed that A. agkistrodontis and Armillifer armillatus constituted a clade Pentastomida which was a sister group of the Branchiura. The complete mt genome sequence of A. agkistrodontis provides important genetic markers for both phylogenetic and epidemiological studies of pentastomids.
Amino Acid Sequence
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China
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Epidemiologic Studies
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Genes, rRNA
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Genetic Markers
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Genome
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Genome, Mitochondrial*
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Humans
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Pentastomida*
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RNA, Transfer
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Siblings
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Tongue*
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Trees
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Zoonoses
2.Characteristics and Impact Factors of Renal Threshold for Glucose Excretion in Patients with Type 2 Diabetes Mellitus.
Xiao Dan YUE ; Jing Yu WANG ; Xin Rong ZHANG ; Ju Hong YANG ; Chun Yan SHAN ; Miao Yan ZHENG ; Hui Zhu REN ; Yi ZHANG ; Shao Hua YANG ; Zhen Hong GUO ; Bai CHANG ; Bao Cheng CHANG
Journal of Korean Medical Science 2017;32(4):621-627
Sodium glucose co-transporter 2 (SGLT-2) inhibitors are newly developed but promising medicine for type 2 diabetes. However, patients with a different renal threshold for glucose excretion (RT(G)) may have a different reaction to this medicine. Therefore, the objective of this study was to investigate the characteristics of RT(G) and its impact factors in patients with type 2 diabetes mellitus (T2DM). The clinical and laboratory data of 36 healthy individuals and 168 in-hospital patients with T2DM were collected and analyzed, RTG was calculated using blood glucose (BG) measured by dynamic BG monitoring, urinary glucose excretion (UGE) and estimated glomerular filtration rate (eGFR). The characteristics of RT(G) were investigated. The risk factors for high RT(G) were analyzed using non-conditional logistic regression analysis. Our results found that RT(G) of the T2DM group was higher than that of the healthy individuals (P < 0.05); and 22.22% from the healthy individuals group but 58.33% from the T2DM group had high RT(G). Age, duration of diabetes, body mass index (BMI), and homeostasis model assessment insulin resistance index (HOMA-IR) were independently associated with high RT(G) (P < 0.05). Further stratified analysis revealed that RT(G) in T2DM patients increased with age, duration of diabetes, and BMI. In conclusion, RT(G) is increased in patients with T2DM, especially in those with longer diabetic duration, higher BMI, and those who are older. Therefore, these patients may be more sensitive to SGLT-2 inhibitors.