Objective To study the effect of sodium valproate ,topiramate on cognitive function of epileptic children of school age .Methods 58 cases of children with epilepsy were recruited in the study(epilepsy group) .58 patients were randomly divided in‐to two groups .Group A :30 cases ,treated with oral administration of sodium valproate .Group B:28 cases ,treated with topiramate . 36 cases of healthy children who underwent health examination during the same period in the hospital were recruited as control group .Cognitive function were assessed before and after treatment for children in epilepsy .Results VIQ ,PIQ ,FIQ of epilepsy group were lower than the control group(P<0 .05) .The VIQ ,PIQ ,FIQ of Group A did′t change significantly after treatment(P>0 .05) .The PIQ of Group B didn′t change significantly after treatment(P>0 .05) ,while VIQ and FIQ were lower after treatment than before treatment(P<0 .05) .Conclusion The side effect of sodium valproate is smaller on cognitive function of epileptic chil‐dren of school age and it is safer compared with topiramate .

Objective To compare the value of dynamic contrast-enhanced MRI(DCE-MRI) and diffusion weight-imaging(DWI) in differentiating hepatic epithelioid angiomyolipoma (HEAML) from hepatocellular carcinoma(HCC).Methods The MR data of 15 HEAML and 50 HCC proved surgically and pathologically were analyzed retrospectively.The DCE-MRI and DWI were performed preoperatively.The size, location, margin, T1-weighted images(T1WI),T2-weighted images(T2WI) and DWI signal intensity(SI),enhancement pattern, central vessel, early draining vein, pseudocapsule were recorded.The apparent diffusion coefficient (ADC) value was also calculated.The differences of these MR features between two groups were compared statistically.Results There was one lesion in each patient.For all 15 HEAML lesions, early draining vein, central vessel and pseudocapsule were displayed in 8,11 and 6 lesions, respectively.The wash in and slow out enhancement pattern was shown in 10 lesions and wash in and wash out pattern shown in others (5/15).The mean ADC value was (1.15±0.31)×10-3 mm2/s.For all 50 HCC lesions, early draining vein, central vessel and pseudocapsule were displayed in 6,5 and 45 lesions, respectively.29 lesions were shown as wash in and wash out enhancement pattern and the others (21/50) as wash in and slow out pattern.The mean ADC value was (1.23±0.29)×10-3 mm2/s.There were significant differences in these MR features including draining vein, central vessel and pseudocapsule (P<0.05), but no differences in size, location, margin, SI(T1WI, T2WI and DWI), dynamic enhancement pattern, ADC value(P>0.05) between HEAML and HCC.Conclusion DCE-MRI is more helpful in differentiating HEAML from HCC than DWI.

On sjogrens' syndrome (SS) clinical treatment,most of the clinician focused on nourishing Yim to moisten dryness.In fact,Yang qi was the metabolic power of the human body fluid,exerting an important role in the incidence and prognosis of SS.For SS of Yang deficiency syndrome,water,Qi and fire can not be guided back to the kidney was the key cause,therefore,warming kidney Yang should be the therapeutic principle.Modified Yimhuo decoction can be used in its treatment.

Due accomplishments in the research of medical humanities and social science in higher medical college was failed to achieve due to the problems of improper intellectual structure of the researchers,prejudices toward this discipline,non-mainstream,non-profession and poor research environment.This article brings forward three proposals which may improve the research of medical humanities and social science,namly the establishment of independent discipline,the system of training and practice for researchers and the construction of problem-centered interdisciplinary research platform.

With the development of mass spectrometry technology and its wide range of applications in the biological field,Veristrat classifier has been applied in non-small cell lung cancer (NSCLC) individualized therapy as well as in other tumors.Oncologists select individualized treatment plan based on peripheral blood veristrat test results.Many trials have verified its guiding role in NSCLC and other tumors' s first line and multi-line individualized therapy.Veristrat classifier provides a new idea and method for individualized treatment of NSCLC and other tumors.

Objectives: To test whether early prophylactic antidepressant treatment by paroxetine has any beneficial influence on the rate of post-stroke depression (PSD) and rehabilitation of stroke patients. Methods: A randomized, placebo controlled study involved 64 consecutive patients admitted to hospital for an acute stroke; they were treated with placebo, paroxetine (20mg/d) respectively. Before and at the end of the observation, we assessed the rate of PSD and activities of daily living (ADL), degree of neurological deficit (modified Edinburgh-Scandinavia scale, MESS) of all the subjects.Results:At the end of 12-week treatment, the treatment group had lower rate of PSD (10.7%) than control (41.4%); and they had lower score in ADL (27.6?4.8/32.8?4.1) and lower score in MESS (11.1?4.3/13.6?3.2).Conclusion:Prophylactic antidepressant treatment by paroxetine can decrease the rate of PSD and improve the neurological function of post-stroke patients.

Endometrial Neoplasms ; metabolism ; pathology ; secondary ; Female ; Humans ; Mesentery ; Middle Aged ; Neprilysin ; metabolism ; Peritoneal Neoplasms ; metabolism ; pathology ; Receptors, Estrogen ; metabolism ; Receptors, Progesterone ; metabolism ; Sarcoma, Endometrial Stromal ; metabolism ; pathology ; secondary

Objective: To determine whether paroxetine would be effective in the treatment of patients with chronic insomnia and to compare efficacy of paroxetine and estazolam on chronic insomnia. Methods: 74 patients with chronic insomnia were divided into 2 groups, receiving treatments of paroxetine and estazolam respectively. All of the subjects were assessed with Pittsburgh Sleep Quality Index (PSQI) and sleep diary. Results: 1. On the eighth day of treatment, estazolam group showed improvement, all the indexes of sleep were better than those before treatment and those of paroxetine group; 2. On the fifteenth day of treatment, paroxetine group showed improvement, all the indexes of sleep were better than those before treatment and those of estazolam group, while the indexes of the estazolam group returned to pre-treatment level. 3. At the end of treatments and 3 months' follow up, paroxetine group still showed better effect in sleep indexes than estazolam group and the pre-treatment level. Conclusion: paroxetine is effective in the treatment of chronic insomnia and shows long-term effect.

Objctive To investigate the zymogenic state and drug resistance of multi-drug resistant Pseudomonas aeruginosa (MDRP) for providing a laboratory basis of combined use of drugs against MDRP in clinical practice. Methods All isolates were isolated by routine procedures and identified by VITEK-2 automatic bacterial identification instrument. Following the CLSI instruction, doubling dilution in agar plates was performed for MIC detection. Results MDRP were 22.77% ( 86.96% for sputum) from 101 strains Pseudomonas aeruginosa, which were isolated from clinical specimens. Positive rates of MDRP producing metallo-?-lactmases were 91.3%, positive rates for producing induced Ampc and plasmid Ampc ?-lactamase were 52.17% and 21.74%, respectively. The ratio between Meropenem and Imipenem higher then 1 was 34.78%. The bacterial inhibitory rates of Polymyxin B and Imipenem were zero, that of Amikaein and Ceftaxidime were 4.35%, that of Ciprofloxacin and Cefoperazone/sulbactam were 43.48%, that of Pazufioxacin and Piperacillin/Tazobactam were 21.74% and 26.07%, and that of Meropenem was 47.83%. The combined use of Cefoperazone/sulbactam, Cefpirome, Piperacillin/Tazobactam with Amikacin resulted in bacteriostatic rate of 65.2%, 47.8%, 43.5%, respectively. Conclusoins MDRP is main micro-organism found in respiratory tract specimens. Drug resistance of MDRP is related to multiple drug-resistant mechanisms. Clinicians should first select enzyme inhibitory-drug (Cefoperazone/sulbactam or Piperacillin/Tazohaetam) with Amikacin or Polymyxin B to treat clinical MORP infection, and re-adjust the type of antibiotics rationally according to patients' symptoms, phenotype of the drug-resistant pathogen, the results of drug susceptibility test, and the effect on the patients.

Objective To explore the neuroprotective effect of honokiol against Parkinson's disease(PD)in mouse model,and investigate the possible mechanism involved.Methods 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)was injected into abdominal cavity of mouse to establish the PD model.Sixty C57BL/6 male mice were randomly allocated into five groups:control group,MPTP model group,amantadine group(positive control,40mg/kg),honokiol group A(10mg/kg)and honokiol group B(30mg/kg).Spontaneous movement test was used to measure the activity frequency of each mouse in 5 minutes.The technique of high performance liquid chromatography-electrochemistry was utilized to detect the changes of dopamine(DA)contents in mouse striatum.Results a)Since the involuntary movement appeared,such as trunk trembling,piloerection,tail extending and movement reduction,the PD model was regarded as having been reproduced successfully.b)The spontaneous movement frequency in 5 minutes of the mice in MPTP model group(102?7)was lower than that in the control group(583?11,P