The article interpreted the important significance of constructing characteristic university of high level on the new situation, from the content and spirit of scientific development view. The article proposed the higher education of TCM should adhere to the scientific development view, highlight the developing demand of characteristic university, Clarify the differences to other universities in historical status, development path,characteristics and service industries. Thus correctly deal with the relationship of inheritance, development and innovation, the relationship of scale, efficiency and development, the relationship of coordinated development between traditional Chinese medical science and medicine, and the relationship between characteristics and sustainable development.

Objective:To investigate the clinical features,treatment and outcomes of systemic lupus erythematosus(SLE)in the elderly. Methods:The Clinical manifestation,laboratory data and treatment effects in the elderly with SLE,were reviewed and compared with those report from the young and middle-aged in the same period.Results:Compared with middle-youth-aged group,dyspnea of first symptoms was obviously more(P

The paper analyzes the advantages of hospital libraries and the necessity of providing living library services to the patients, designs living library services which include collection, publication, classification, catalogue, circulation and conservation.It also dis-cusses the evaluation mode of living library services provided by hospital libraries so as to provide the most convenient and direct high quality resources to the patients and give full play to library in knowledge communication and resources sharing.

OBJECTIVE:To observe the clinical efficacy Shuangyin suppository in the treatment of candidial vaginitis.METHODS:A total of 120 patients with candida albicans vaginitis were enrolled:60 were randomly assigned to receive Shuangyin suppository(trial group,1～2 pill qn.via vagina) for 10 days,another 60 to receive Baofukang suppository(control group,1～2 pill qn.to put in vagina) for 10 days.A total of 3 courses of treatment were conducted for both group(one course of treatment was conducted in each menstrual cycle).RESULTS:After 3 course treatment,54 cases(90%) were cured and 6(10%) showed excellent efficacy for the treatment group;however,45 cases(75%) were cured and 15 cases(25%) showed excellent efficacy for the control group.There were significant differences in the cure rates between the trial group and the control group(P

Objective To discuss the influence of phosphocreatine on serum N end B type natriuretic peptide(NT-proBNP) and cardiac function in patients with congestive heart failure (CHF).Methods Ninetysix patients with CHF were randomly divided into the control group (n =47) and research group (n =49).The patients of the control group were given conventional therapy for treating CHF while the research group were given phosphocreatine based on treatment of the control group,and the course was 4 weeks.The total effective rate and left ventricular end diastolic diameter (LVEDD),left ventricular end systolic diameter (LVESD),left ventricular ejection fraction(LVEF) and NT-proBNP of pretherapy and post-treatment between the two groups were compared.Results There were no statistically significant differences about LVEDD,LVEDD,LVEF and BNP between the two groups (all P＞ 0.05);After treatment,LVEDD in the control group and the observation group patients were (53.5±5.6) mm,(46.4±4.5) mm,LVESD were ((39.9±5.3) mm,(34.6±4.8) mm and NT proBNP were (495.8±42.2) ng/L,(374.4±38.4) ng/L,significantly lower than before treatment ((58.3±6.4) mm,(58.4±6.8) mm;(48.4±6.3) mm,(48.7±6.2) mm;(875.4±64.8) ng/L,869.2 ± ±67.5) ng/L),and LVEF was higher than before treatment significantly (observation group by (35.8±3.2)％ rose to (52.6± 5.2) ％;control group by (36.4± 3.3) ％ rose to (44.5 ± 4.2) ％),and the observation group compared with the control group,the difference was statistically significant(P＜0.05).The total effective rate of research group was evidently higher than that of control group,the difference was statistically significant(93.8％ (45/49) vs.75.0％(36/47);x2=6.836,P=0.037).Conclusion Phosphocreatine can effectively strengthen the heart systolic functionincrease,LVEF,the serum NT-proBNP and enhance the total effective rate of patients with congestive heart failure.

Exosomes are nanometer membranous vesicles which can be distributed in a variety of biological fluids,including peripheral blood,urine,saliva and so on.Currently,the multi-step differential centrifugation is a efficient method which can be used to isolate exosomes.Exosomes are released by all types of cells.Exosomes can carry proteins and RNAs from derived cells,involve in exchange of information between cells,and play an important role in physiological and pathological processes of immunoregulation and inflammatory responses.Age-related macular degeneration (AMD) is the leading indication of severe visual impairment in adults over 50 years old.The exact etiology of AMD is still unknown,and its pathogenesis may involve various factors.New studies showed that exosomes secreted by retinal pigment epithelium (RPE) cells may be associated with AMD.The elevated levels of protein in exosomes from RPE,such as αB-crystalline,are associated with druse in AMD.Stress-altered exosomes proteins were found involving in regulation of apoptosis and survival of RPE.RPE cells membrane complement regulators,CD46 and CD59,could contribute to lesion formation in the outer retina and Bruch's membrane during the development of AMD.Further,exosomes from RPE cells may be associated with the genesis of choroidal angiogenesis.There remain thorough studies to be conducted,which would reveal new approaches for the diagnosis and treatment of AMD in the future.

AIM:Stress response induced by severe trauma can activate free radical, endothelial cell, and mononuclear macrophage to regulate the production and release of mediators of inflammation. In this study, we investigated the influence of semi-hepatectomy on cytokine in serum. METHODS:The experiment was performed at Clinical Laboratory of Datong Seventh People's Hospital from April to July 2006. The experimental procedure was accorded with animal ethical standards. Twenty-five healthy rabbits were selected and randomly divided into two groups. In hepatectomy group (n=20), semi-hepatectomy was performed by regular approach, following by abdominal closure when there was no active bleeding. In control group (n=5), only abdominal opening and closure was conducted. Peripheral venous blood was harvested 1 day before and 24 hours, 1, 2, 3, and 4 days after surgery (IGF) to examine the levels of cytokine in serum such as interleukin-2 (IL-2), IL-6, IL-8, tumor necrosis factor (TNF) and insulin-like growth factor by radioimmunity. RESULTS:Twenty-five rabbits were all included in final analysis. Compared with the control group, IL-2 increased 24 hours after surgery, and reduced even lower than preoperative level 1 week after surgery, but then increased gradually and approached to preoperative level 4 weeks after surgery. IL-6 and IL-8 were elevated within 24 hours after surgery, and reached the peak at 3 weeks, then began to reduce until the normal level 4 weeks after surgery. TNF decreased 24 hours after surgery, and then increased but decreased again 4 weeks after surgery. IGF increased 24 hours after surgery, reached the peak 2 weeks after surgery, and reduced to normal level 4 weeks after surgery. CONCLUSION:Hepatectomy can induce decrease in IL-2, T cell growth factor in peripheral blood, in rabbits.

Objective To investigate the expression of cannabinoid receptor type 2 (CNR2) in skin lesions of psoriasis vulgaris,and to explore its significance.Methods Tissue samples were obtained from lesions and perilesional skin of 20 patients with psoriasis vulgaris,and normal skin of 10 human controls without psoriasis or other autoimmune dermatoses.Real-time fluorescence-based quantitative PCR and immunohistochemistry were performed to determine the mRNA and protein expression levels of CNR2 in these samples.Statistical analysis was carried out by using two-sample t test and chi-square test.Results CNR2 mRNA and protein were expressed in the normal control skin,lesional skin and perilesional skin tissues.As immunohistochemistry showed,CNR2 was distributed diffusedly in the prickle cell layer in lesional skin,but expressed in the basal cell layer of the epidermis in normal control skin and perilesional skin.The mRNA expression level (2-△△α) of CNR2 was significantly higher in lesional skin than in normal control skin and perilesional skin tissues (3.97 vs.1.00 and 1.49,both P ＜ 0.05),but similar between normal control skin and perilesional skin tissues (P ＞ 0.05).The expression rate of CNR2 protein was significantly higher in lesional skin (90％ (18/20) than in perilesional skin (15％ (3/20),x2 =22.56,P ＜ 0.01) and normal control skin tissues (10％ (2/20),c2 =18.37,P＜ 0.01),while there was no significant difference between normal control skin and perilesional skin tissues (x2 =0.14,P =0.70).Conclusions The mRNA and protein expressions of CNR2 are both increased in skin lesions of psoriasis vulgaris,suggesting that CNR2 may be related to the occurrence and development of psoriasis vulgaris.

Objective To analyze routine CT and high-resolution CT (HRCT) characteristics of acute miliary pulmonary tuberculosis (AMPT) and miliary lung metastases (MLM). Methods CT and HRCT data of 25 patients with AMPT and 30 with MLM were retrospectively reviewed; nodular characteristics and other complicated findings were observed. Results No difference was found in size, density, distribution and margin of miliary nodule between AMPT and MLM (P＞0.05). Ground-glass opacities and consolidation in AMPT was more than those in MLM (P＜0.05), while multiple small cavitates, interlobular septal thickening, pleural thickening and lymph node increasing were more obvious in MLM than in AMPT (P＜0.05). Conclusion CT characteristics of AMPT and MLM are different and contribute to the differential diagnosis of the two diseases.

Objective To explore the clinical characteristics and treatment of methylmalonic acidemia(MMA) in order to improve our understanding of it.Methods We analyzed the clinical manifestations,laboratory examinations and treatments of 26 cases of methylmalonic acidemia in children.Results Twenty-four cases were involved in nervous system.Nine patients were involved in renal system.Eight cases of hematological involved.Liver enzyme elevated in 2 cases as well as the cardiac system were involved in 3 cases.One case was with pneumonia onset.The laboratory findings showed metabolic acidosis in 12 cases,hyperhomocysteinemia in 8 cases and remarkable elevation of urinary methylmalonic acid concentration in all cases.Some abnormalities in globus pallidus and cerebral white matter as well as diffuse cerebral atrophy were noted by the brain CT and MRI in 15 cases.Sixteen children have received therapy of vitamin B12,and supplementation of L-carnitine with restricted-protein diet.The follow-up for a period ranging from 3 months to 1.5 years( mean 8.5 months) of 15 cases with medical therapy showed a favorable outcome of nervous system improvement in 12 cases,however,2 patients died from severe metabolic acidosis.8 patients with renal involvement were normal in urine routine and renal function.Conclusion Methylmalonic acidemia has different clinical features,so early urine organic acids analysis by GC/MS method is essential Long-term and reasonable treatment after diagnosis is an effective way to improve the prognosis.