The paper analyzes the advantages of hospital libraries and the necessity of providing living library services to the patients, designs living library services which include collection, publication, classification, catalogue, circulation and conservation.It also dis-cusses the evaluation mode of living library services provided by hospital libraries so as to provide the most convenient and direct high quality resources to the patients and give full play to library in knowledge communication and resources sharing.

Objective:To investigate the clinical features,treatment and outcomes of systemic lupus erythematosus(SLE)in the elderly. Methods:The Clinical manifestation,laboratory data and treatment effects in the elderly with SLE,were reviewed and compared with those report from the young and middle-aged in the same period.Results:Compared with middle-youth-aged group,dyspnea of first symptoms was obviously more(P

Exosomes are nanometer membranous vesicles which can be distributed in a variety of biological fluids,including peripheral blood,urine,saliva and so on.Currently,the multi-step differential centrifugation is a efficient method which can be used to isolate exosomes.Exosomes are released by all types of cells.Exosomes can carry proteins and RNAs from derived cells,involve in exchange of information between cells,and play an important role in physiological and pathological processes of immunoregulation and inflammatory responses.Age-related macular degeneration (AMD) is the leading indication of severe visual impairment in adults over 50 years old.The exact etiology of AMD is still unknown,and its pathogenesis may involve various factors.New studies showed that exosomes secreted by retinal pigment epithelium (RPE) cells may be associated with AMD.The elevated levels of protein in exosomes from RPE,such as αB-crystalline,are associated with druse in AMD.Stress-altered exosomes proteins were found involving in regulation of apoptosis and survival of RPE.RPE cells membrane complement regulators,CD46 and CD59,could contribute to lesion formation in the outer retina and Bruch's membrane during the development of AMD.Further,exosomes from RPE cells may be associated with the genesis of choroidal angiogenesis.There remain thorough studies to be conducted,which would reveal new approaches for the diagnosis and treatment of AMD in the future.

The article interpreted the important significance of constructing characteristic university of high level on the new situation, from the content and spirit of scientific development view. The article proposed the higher education of TCM should adhere to the scientific development view, highlight the developing demand of characteristic university, Clarify the differences to other universities in historical status, development path,characteristics and service industries. Thus correctly deal with the relationship of inheritance, development and innovation, the relationship of scale, efficiency and development, the relationship of coordinated development between traditional Chinese medical science and medicine, and the relationship between characteristics and sustainable development.

Objective To discuss the influence of phosphocreatine on serum N end B type natriuretic peptide(NT-proBNP) and cardiac function in patients with congestive heart failure (CHF).Methods Ninetysix patients with CHF were randomly divided into the control group (n =47) and research group (n =49).The patients of the control group were given conventional therapy for treating CHF while the research group were given phosphocreatine based on treatment of the control group,and the course was 4 weeks.The total effective rate and left ventricular end diastolic diameter (LVEDD),left ventricular end systolic diameter (LVESD),left ventricular ejection fraction(LVEF) and NT-proBNP of pretherapy and post-treatment between the two groups were compared.Results There were no statistically significant differences about LVEDD,LVEDD,LVEF and BNP between the two groups (all P＞ 0.05);After treatment,LVEDD in the control group and the observation group patients were (53.5±5.6) mm,(46.4±4.5) mm,LVESD were ((39.9±5.3) mm,(34.6±4.8) mm and NT proBNP were (495.8±42.2) ng/L,(374.4±38.4) ng/L,significantly lower than before treatment ((58.3±6.4) mm,(58.4±6.8) mm;(48.4±6.3) mm,(48.7±6.2) mm;(875.4±64.8) ng/L,869.2 ± ±67.5) ng/L),and LVEF was higher than before treatment significantly (observation group by (35.8±3.2)％ rose to (52.6± 5.2) ％;control group by (36.4± 3.3) ％ rose to (44.5 ± 4.2) ％),and the observation group compared with the control group,the difference was statistically significant(P＜0.05).The total effective rate of research group was evidently higher than that of control group,the difference was statistically significant(93.8％ (45/49) vs.75.0％(36/47);x2=6.836,P=0.037).Conclusion Phosphocreatine can effectively strengthen the heart systolic functionincrease,LVEF,the serum NT-proBNP and enhance the total effective rate of patients with congestive heart failure.

AIM:Stress response induced by severe trauma can activate free radical, endothelial cell, and mononuclear macrophage to regulate the production and release of mediators of inflammation. In this study, we investigated the influence of semi-hepatectomy on cytokine in serum. METHODS:The experiment was performed at Clinical Laboratory of Datong Seventh People's Hospital from April to July 2006. The experimental procedure was accorded with animal ethical standards. Twenty-five healthy rabbits were selected and randomly divided into two groups. In hepatectomy group (n=20), semi-hepatectomy was performed by regular approach, following by abdominal closure when there was no active bleeding. In control group (n=5), only abdominal opening and closure was conducted. Peripheral venous blood was harvested 1 day before and 24 hours, 1, 2, 3, and 4 days after surgery (IGF) to examine the levels of cytokine in serum such as interleukin-2 (IL-2), IL-6, IL-8, tumor necrosis factor (TNF) and insulin-like growth factor by radioimmunity. RESULTS:Twenty-five rabbits were all included in final analysis. Compared with the control group, IL-2 increased 24 hours after surgery, and reduced even lower than preoperative level 1 week after surgery, but then increased gradually and approached to preoperative level 4 weeks after surgery. IL-6 and IL-8 were elevated within 24 hours after surgery, and reached the peak at 3 weeks, then began to reduce until the normal level 4 weeks after surgery. TNF decreased 24 hours after surgery, and then increased but decreased again 4 weeks after surgery. IGF increased 24 hours after surgery, reached the peak 2 weeks after surgery, and reduced to normal level 4 weeks after surgery. CONCLUSION:Hepatectomy can induce decrease in IL-2, T cell growth factor in peripheral blood, in rabbits.

OBJECTIVE:To observe the clinical efficacy Shuangyin suppository in the treatment of candidial vaginitis.METHODS:A total of 120 patients with candida albicans vaginitis were enrolled:60 were randomly assigned to receive Shuangyin suppository(trial group,1～2 pill qn.via vagina) for 10 days,another 60 to receive Baofukang suppository(control group,1～2 pill qn.to put in vagina) for 10 days.A total of 3 courses of treatment were conducted for both group(one course of treatment was conducted in each menstrual cycle).RESULTS:After 3 course treatment,54 cases(90%) were cured and 6(10%) showed excellent efficacy for the treatment group;however,45 cases(75%) were cured and 15 cases(25%) showed excellent efficacy for the control group.There were significant differences in the cure rates between the trial group and the control group(P

Nosocomial infection is a serious problem in the diagnosis, treatment and management of neonatal disease. Neonatal intensive care unit (NICU) is high risk place for nosocomial infections whose clinical features vary with age, nation and region. The improvemnts in hand hygiene measures and antibiotic stewardship and control of the risk are recommended to effectively prevent nosocomial infections in NICU and to improve the healthcare service in neonates.

Objective To investigate the effect of serum uric acid (UA) on cardiovascular diseases in hemodialysis patients. Methods The serum level of uric acid and other laboratory indexes of 80 hemodialysis patients were detected,and the left ventricular mass index (LVMI) and left ventricular ejection fraction (LVEF) were detected by ultrasonic cardiography examination. Results According to the serum level of UA, the hemodialysis patients were divided into 2 groups:the group with high serum level of UA and the group with normal serum level of UA. There were significant differences (P<0.05) in hypertension history,the period of hypertension history, systolic blood pressure before hemodialysis between the two groups. The serum levels of UA,creatinine, triglyceride, low density lipoprotein cholesterol, C-reactive protein, brain natriuretic peptide and LVMI were significantly higher,while the serum levels of albumin,pre-albumin,high density lipoprotein cholesterol, LVEF were lower in the group with high serum level of UA than those in the group with normal high serum level of UA (P<0.05) . Furthermore, the serum levels of UA in 80 patients was positively correlated to systolic blood pressure before hemodialysis, serum creatinine, triglyceride, low density lipoprotein cholesterol, C-reactive protein, brain natriuretic peptide, and LVMI (P<0.05), while it was negatively correlated to serum albumin, pre-albumin, high density lipoprotein cholesterol and LVEF (P<0.05) . Conclusion High serum level of uric acid is associated with the onset of cardiovascular diseases in hemodialysis patients.

Objective To investigate the effect of recombinant human erythropoietin (rhEPO) on the expression of glutamine synthetase (GS) of cultured rat retinal Müller cells in high glucose environment in vitro.Methods Mtüller cells were isolated from retinas of 10 Sprague-Dawley rats at postnatal day three to five by trypsin digestion,and were randomly divided into six groups,including normal control group,high glucose group,high glucose +5 U/ml rhEPO group,high glucose+ 10 U/ml rhEPO group,high glucose+ 20 U/ml rhEPO group,high glucose+40 U/ml rhEPO groups.After 48 hours,the apoptosis of retinal Müller cells were assayed by terminal transferase-mediated DNA end labelling assay,and the expression levels of GS protein were detected with semi-quantitative immunocytochemistry.Results Compared with the normal control group,the cell viability and GS protein were reduced while the cell death increased in Müller cells cultured in high glucose,the difference was statistically significant (t =27.4,P ＜ 0.01).Compared with the high glucose group,rhEPO treatment reduced the apoptotic Müller cells (t=857.2,2 374.6,2 473.2,2 537.7; P＜0.01),induced the expression of GS proteins (t=3.2,18.0,22.5,26.4; P＜0.05).Conclusions rhEPO can protect Müller cells from apoptosis under high glucose condition.The mechanism may be related to its function to up-regulate the GS protein expression,promote glutamic acid cycle,and reduce the excitotoxicity effects of high concentration of glutamate.