Acupuncture Therapy ; Adult ; Dystonia ; therapy ; Female ; Humans

Objective: To observe the clinical efficacy of spleen-invigorating and qi-benefiting pediatric massage (tuina) for treating recurrent respiratory tract infection in children with cerebral palsy due to qi deficiency of spleen and lung. Methods: A total of 70 children with cerebral palsy who suffered from recurrent respiratory tract infection due to qi deficiency of spleen and lung were randomized into an observation group and a control group by the random number table method, with 35 cases in each group. Both groups were treated with conventional rehabilitation training, while the observation group was given additional spleen-invigorating and qi-benefiting pediatric massage, and the control group additionally took oral Yu Ping Feng granule. The clinical efficacy was evaluated by the total effective rate, traditional Chinese medicine (TCM) symptom score, and serum levels of immunoglobulin (Ig) A, IgM and IgG. Results: The difference in total effective rate between the two groups after treatment was statistically significant (P<0.05). After treatment, the TCM symptom scores in both groups decreased to varying degrees than those before treatment, and the intra-group differences were statistically significant (all P<0.01); the differences in the scores of various TCM symptoms between the two groups were statistically significant (all P<0.05). After treatment, the levels of IgA, IgM and IgG of the children in both groups increased to varying degrees, and the intra-group differences were statistically significant (all P<0.05). The between-group differences in the IgA, IgM and IgG levels after treatment were statistically significant (all P<0.05). Conclusion: Spleen-invigorating and qi-benefiting pediatric massage can effectively treat recurrent respiratory tract infection due to qi deficiency of spleen and lung in children with cerebral palsy, relieve the clinical symptoms and improve immune function, and thus is worthy of clinical promotion and application.

Objective To investigate the symptoms on depression in patients with viral hepatitis. Methods A cross-sectional study was conducted among the patients with viral hepatitis in infectious diseases Hospital of Taiyuan. The questionnaire included a Eysenck Personality Questionnaire, self-rating depression scale (SDS) , and a self-designed one related to information regarding general conditions of the disease and social support. Results (1)Depression symptom prevalence rate among chronic viral hepatitis patients was 54.7% (116/212). (2) Factors as age, occupation, education, confirmed time, number of recurrence and anti-virus treatment, self-confidence on recovery, satisfaction on the surrounding environment etc. that might be associated with depression. (3) The severity of depression was significantly negative correlation with social support scores, objective support scores, subjective support scores (r=-0.262, P=0.000;r=-0.228, P=0.001 ; r=-0.270, P=0.000). (4) There was positive correlation noticed between severity of the depressive disorder and Eysenck Personality two dimensions scores, while the scores of introversion and extroversion scores were negatively correlated (r=-0.330, P=0.000) but positively correlated to the emotional stability scores (r=0.309, P=0.000). Conclusion (1) Patients with hepatitis showed symptoms of depression to a certain degree. (2) Factors as age, occupation, education, economic situation, confirmed time of diagnosis, number of recurrence and anti-virus treatments, confidence on recovery, satisfaction on the surrounding environment might be associated with symptoms of depression. (3) There was positive correlation between severity of depressive and Eysenek Personality two dimensions scores but the scores of introversion and extroversion scores were negatively correlated.

Animals ; DNA Damage ; Dose-Response Relationship, Drug ; Isotope Labeling ; Male ; Phosphorus Radioisotopes ; analysis ; Rats ; Rats, Sprague-Dawley ; Trichloroethylene ; toxicity

Using the absorbent resin, silica gel and ODS column chromatography as well as semi-preparative HPLC, ten compounds were isolated from 70% ethanol extract of tubers of Dioscorea zingiberensis C. H. Wright, and their structures were elucidated as trigoneoside XIIIa (1), parvifloside (2), trigoneoside IVa (3), deltoside (4), protobioside (5), lilioglycoside k (6), zingiberensis newsaponin I (7), deltonin (8), prosapogenin A of dioscin (9), and trillin (10) on the basis of NMR and MS spectral data analysis. Among these compounds, 1, 3, 5 and 6 were isolated from this plant for the first time. In the screening test on platelet aggregation, compounds 7 and 8 exhibited induction effect on platelet aggregation, while compound 9 exhibited significant inhibitory effect on platelet aggregation in vitro.
Animals ; Dioscorea ; chemistry ; Drugs, Chinese Herbal ; chemistry ; pharmacology ; Male ; Mass Spectrometry ; Molecular Structure ; Platelet Aggregation ; drug effects ; Rats ; Rats, Wistar ; Saponins ; chemistry ; pharmacology

OBJECTIVETo observe the effects of Cinnamyl aldehyde (CA) on NIH3T3 cell cycle and explore the possible mechanism further.

METHODFlowcytometry was used for observing cell cycle distribution. Expressions of proliferation cell nuclear antigen (PCNA) and Cyclin D1 protein in NIH3T3 cells were assessed by immunocytochemistry.

RESULTAfter culture with CA for 24 hours, the percentage of populations of S phase was enhanced by 3% (P < 0.05) and cell proliferation index (PrI, S + G2/M) was increased by 3.5% (P < 0.01) , but G2/M phase had no obvious changes. The expressions of Cyclin D1 and PCNA proteins were improved markly by CA compared with controlgroup (P < 0.01).

CONCLUSIONCA could promote more cells in G0/G1 phase into S phase, which may be related to the regulation of the expressions of PCNA and Cyclin D1.

Acrolein ; analogs & derivatives ; isolation & purification ; pharmacology ; Animals ; Cell Cycle ; drug effects ; Cell Proliferation ; drug effects ; Cinnamomum ; chemistry ; Cyclin D1 ; metabolism ; Flow Cytometry ; Immunohistochemistry ; Mice ; NIH 3T3 Cells ; Plants, Medicinal ; chemistry ; Proliferating Cell Nuclear Antigen ; metabolism ; S Phase ; drug effects

Objective To study the attitude of patients for the PICC and analyse its relevant factors for patients' indwelling selection,so as to provide evidence for the promotion of PICC and health educations for clinical nurse.Methods The questionnaire survey was used and108 patients that had indwelling indications in Beijing Chao-Yang Hospital,between April and May in 2010 were recruited.They were divided into acceptance group( n =50) and refuse group( n =58) and were investigated with self-designed questionnaire.Results Both of two groups had significantly differences in terms of gender,payment method for health care,potential risk of it,financial burden from it,impacts on daily life,and the trust from the medical personnel ( P ＜ 0.05 ).The absolutely right percent of can avoid needling during transfusion period for the attitude on the PICC function,maybe pipe block of PICC for the attitude on the danger of PICC,such needle is very expensive for the attitude on the financial burden of PICC,influencing eating for the attitude on the influencing daily life of PICC of the refuse group respectively was 46.6％,50.0％,44.8％,22.4％,and that of acceptance group was 86.0％,12.0％,28.0％,6.0％,and the difference was statistically significant ( P ＜ 0.01 or P ＜ 0.05 ).There was significantly difference in the attitude of PICC can reducing the puncture times,alleviating pain was the necessary therapy condition between two groups ( P ＜ 0.05 ),as well as in the attitude of the PICC has the danger of infection,taking off,forming thrombus,catheter misplacement,fracture,and the operation safety ( P ＜ 0.05 ).there was no significantly difference on the attitude of existing dangerous in the PICC installing( P ＞ 0.05 ),while the difference in the attitude of the financial burden influence of PICC on the daily life between two groups was significantly( P ＜ 0.05 ).Conclusions From the view of patients with indwelling PICC indications,most patients agree that PICC can reduce the pain suffered from long-term infusion,but they comment that fees are high,and they have different attitude towards the risk of indwelling PICC and the influences of their daily lives.Most patients trust medical staff and not believe that indwelling PICC affect their psychological status and themselves image.Therefore,patients indwelling selection is correlate with the potential risk of indwelling,the impact of daily lifc,relevant economic burden,psychological and social factors.

OBJECTIVETo survey patients with chronic hepatitis B (CHB) to determine their perceptions of CHB-related quality of life (QOF) and to determine the factors influencing this measure.

METHODSA total of 268 patients with CHB (disease group) and 205 healthy individuals (control group) completed the World Health Organization (WHO)QOL-BREF life assessment survey and a self-designed questionnaire of health and QOL. The groups' responses were comparatively analyzed by the cluster sampling method and the independent samples t-test. The strength of influence of each factor on the patients' perceptions of QOL was determined by multiple stepwise regression and one-way ANOVA.

RESULTSThe disease group had significantly lower scores than the control group for overall QOL (62.88 ± 8.22 vs. 67.31 ± 5.82), the physiological area (PHYS: 64.71 ± 15.05 vs. 73.21 ± 11.26), the psychological area (PSYCH: 64.35 ± 14.71 vs. 68.94 ± 10.13), the social relations area (SOCIL: 67.20 ± 12.98 vs. 69.83 ± 8.65), the environmental area (ENVIR: 59.58 ± 13.23 vs. 63.97 ± 10.24), the QOL self-assessment (60.75 ± 21.54 vs. 66.90 ± 17.57) and the health self-assessment (58.13 ± 19.15 vs. 76.26+/-14.27) (all, P less than 0.05). Multiple stepwise regression analysis identified the following parameters as risk factors of PHYS: depression (P less than 0.001), perception of being seriously ill (P less than 0.001), self-payment for treatment (P = 0.003), CHB significant impact on income (P = 0.002), poor appetite (P = 0.002), langur (P less than 0.001), and fear of infecting others (P = 0.022). Confidence of treatment was a protective factor of PHYS (P = 0.001). The risk factors of PSYCH were depression (P less than 0.001) and recurrence (P less than 0.001), and the protective factors were confidence of treatment (P = 0.003) and male sex (P = 0.014). The risk factors of SOCIL were depression (P less than 0.001, dissatisfaction with the attitude of the people around (P = 0.001), recurrence (P = 0.008), and advanced age (P = 0.009), and the protective factors were social support (P less than 0.001) and confidence of treatment (P = 0.015); however, the scores were significantly different for different occupations (P = 0.008). The risk factors of ENVIR were depression (P less than 0.001), dissatisfaction with the attitude of the people around (P less than 0.001), living in rural area (P = 0.007), and recurrence (P = 0.016).

CONCLUSIONPatients should be monitored for depressive symptoms during the course of clinical medical care for CHB so that psychological care may be initiated in a timely manner. It is important to strengthen communication between healthcare professionals and patients in order to improve the patient's perception of social support and quality of life.

Adolescent ; Adult ; Aged ; Case-Control Studies ; Female ; Hepatitis B, Chronic ; Humans ; Male ; Middle Aged ; Quality of Life ; Surveys and Questionnaires ; Young Adult

OBJECTIVETo observe the effect of the compound Chinese traditional drug Xianling Gubao Capsule on the semen quality of infertile males.

METHODSWe treated 66 infertile men with Xianling Gubao Capsule for 24 months, and analyzed the semen quality and sperm morphology before and after the treatment.

RESULTSTwo months after the medication, sperm concentration was increased by a small margin, but no statistically significant changes were observed in sperm vitality and motility (P > 0.05), the rate of morphologically normal sperm was significantly raised from 25.8% before treatment to 57.6% (P < 0.05) in those with the normal rate > or = 15%, but decreased from 53.0% to 25.8% (P < 0.05) in those with the normal rate < 9%. Among the 7 cases of oligospermia, the rate of morphologically normal sperm was elevated to an average of 10.9% after the 4-month medication, significantly different from the baseline rate of 5.8% (P < 0.05). Five spontaneous pregnancies and 1 successful IVF-ICSI were achieved during the treatment.

CONCLUSIONXianling Gubao Capsule can improve semen quality and significantly increase the percentage of morphologically normal sperm.

Adult ; Capsules ; Female ; Humans ; Infertility, Male ; drug therapy ; Male ; Phytotherapy ; Pregnancy ; Semen Analysis ; Sperm Count ; Sperm Motility ; Treatment Outcome

Objective To investigate the prevalence rate of insomnia and its influence factor in adults from Bozhou region,and determine the correlation of sleep hygiene with insomnia in adult population.Methods Eight hundred and three subjects were recruited in the study by multi-stage stratified random sampling from people aged 18 years or more than 18 years.Athens Insomnia Scale (AIS)and sleep hygiene practices scale were used to evaluate the insomnia and its related factors.Results One hundred and ninety-two adults(23.9％)were identified as insomnia with dissatisfaction of sleep quality,shortage of sleep time(＜56.5 h/night)and earlier wake-up than expectation as its main manifestations; and the prevalence rate ofinsomnia in females(98/354,27.7 ％)was significantly higher as compared with that in males(94/449,20.9％,P＜0.05); prepared military personnel enjoyed the highest insomnia rate(37/99,37.3％),followed by freelance/temporaries(55/181,30.4％)with significant difference between these 2 groups(P＜0.05).The correlation analysis between the total scores of AIS and problems of sleep hygiene indicated that such factors as prescription of sleep medication,hunger at bed,drinking in purpose of helping sleeping,and worry about insomnia beofore sleep or at daytime were positively related to the total scores ofAIS(P＜0.05); nap or snooze was negatively related to the total scores of AIS(P＜0.05).Conclusion There is a high proportion of insomnia in prepared military personnel and freelance/temporaries from Bozhou region; poor sleep hygiene habits as prescription of sleep medication,hunger at bed,drinking in purpose of helping sleeping,and worry about insomnia beofore sleep or at daytime can induce insomnia.