Objective To investigate the impact of psoriacis on quality of life in patients with psoriasis. Methods A questionnaire interview included daily life and activities social activities and psychologic status were conducted of. Results 48 patients, 14 patients(29%) were impacted on quatity of life in heavy, 23 patiemts(48%) in middle, 11 patients(23%) in mildly no impact in zero. Conclusion The psoriasis valgaris influenced the Quality of life.

Bimolecular fluorescence complementation (BiFC) assay is an innovative approach to investigate protein interactions, based on the reassembly of protein fragments of the fluorescent proteins which directly report interactions. The fluorescent proteins tolerate circular permutation and insertions of foreign proteins with maintenance of fluorescence. So when the proteins fused to the reporter fragments interact with each other, a direct readout of the association would be given from the facilitating reassembly of the active reporter protein. Moreover, with distinct spectra difference of the fluorescent protein family members, BiFC assay is expanded to multicolor BiFC assay which enables visualization of interactions between different proteins in the same cell and comparison of the efficiencies of complex formation with alternative interaction partners. From it first reported in Molecular Cell in 2002 till now, this approach has been used on the networks of protein interaction in mammal cells, plant cells or even E.coli, and researches on transcription factors, G protein ?? dimmers, protein ubiqutination and so on.

Objective To study the views of clinical nursing staff about current nursing quality evaluation so as to find the problems in nursing quality evaluation.Method 25 head nurses and nurses were interviewed using semi-structured open interview about nursing quality evaluation.Result The current nursing quality evaluation system was lower in sensitivity,focusing more on nursing skills but less on nursing evaluation of nursing specialties.Conclusions The system of current nursing quality evaluation lacks of nursing evaluation of nursing specialties and therefore cannot meet the requirements for the development of nursing specialty. Therefore,it is urgent to regulate an evaluation system for nursing specialties.

Stathmin is a novel member of microtubule-destabilizing proteins that play a critical role in the regulation of the dynamic equilibrium of microtubules during different phases of the cell cycle.The overexpression of stathmin was found in different type of cancer.Inhibition of stathmin expression in malignant cells may interfere with their orderly progression through the cell cycle.Overexpression of stathmin can affect the action of antimicrotuble drugs by markedly decreasing binding of paclitaxel,and increasing binding of Vinca alkaloids.In addition,stathmin provides an attractive molecular target for cancer therapy.It may be possible to combine adenovirus-mediated anti-stathmin ribozyme therapy with a chemotherapeutic agent such as taxol to obtain a more potent antiproliferative and antitumor effect.

Aging ; Arteriosclerosis ; pathology ; Blood Vessels ; pathology ; Cellular Senescence ; Humans ; Medicine, Chinese Traditional

Objective:To evaluate the clinical efficacy and safety of Tongqiao Biyan granules in the treatment of sinusitis. Meth-ods:Totally 240 cases of sinusitis were randomly divided into two groups, each group had 120 cases. The patients in observation group were treated with 1 bag of Tongqiao Biyuan granules, 3 times a day, while the patients in control group were treated with busesonide nasal spray 100 μg each side nasal cavity, once a day. After 3 weeks,curative effect and adverse drug reaction of the two groups were observed. Results:After the treatment, nasal congestion, runny nose, headache, cough and other signs and symptoms were improved more significantly in the observation group than those in the control group (P<0. 05), the total effective rate of the observation group was 92. 5%, while that of the control group was 79. 2%, the difference was significant (P<0. 05). During the treatment, the two groups showed no obvous adverse drug reactions. Conclusion: The effect of Tongqiao Biyuan granules in the treatment of sinusitis is significant with no obvious adverse drug reactions, which should be recommended to use in clinic.

Textbooks are the base of teaching.The physiology textbooks used in medical education was compared between China and the United States.Guyton and Hall Textbook of Medical Physiology was chosen as the major representative of the United States.The overall framework, the selection and arrangement of the contents, the application of tables and pictures, and the relationship between basic medicine and clinical medicine were discussed.This paper may provide some information for remodeling of specialized course system and teaching contents of physiology, especially for improving the constructive quality of textbooks in the future.

Objective The aim of this study is to investigate the effects of the initial amount of total RNA input,adapter dilution and PCR amplification cycles on the results of small RNA library preparation and high-throughput sequencing.Methods Based on the sequencing reads number,the number of detected miRNAs and the accuracy of quantitative detection,we explored the effects of initial Total RNA,dilution ratio and PCR cycles on the quality of microRNA library preparation and high-throughput sequencing,respectively.Results For libraries preparation of the normal RNA input(1 μg),the adapter dilution combined with 22 PCR cycles could gain the best quality of sequencing.In the low-input libraries(10 ng),adapter dilution and increased PCR cycles would also improve the quality of sequencing,but as compared with the 1 μg library,there was lower correlation with microarray quantitative results in general.Conclusions The initial amount of RNAs input has the biggest effects on the quality of sequencing,and the quantity accuracy rate of low-input libraries is lower than the normal libraries generally.Increasing the PCR amplification cycles properly is indispensable to low-input libraries.

The energy cost of the daily major activities, the basal metabolic rates (BMR), resting metabolic rates (RMR) and total energy expenditure of university students per day under normal conditions were determined respectively by Douglas' method. The average BMR of male and female subjects were 2.80?0.14 and 2.74?0.13 kJ.m-2min-1. (0.669 and 0.656 kcal?m~2?min-1) respectively. The total energy expenditure per day of male students was 11.32 MJ, and of female students 9.92 MJ per day. The energy cost of different activity can be used as the basic data in studies of energy metabolism.

The fetal stage is a critical period for brain development. Intrauterine growth restriction(IUGR)af-fects the growth of fetus and impairs the brain development severely,resulting in long - term neurological sequelae such as motor and behavioral disorders. Since their brain underdevelopment originated in the uterus,postnatal interventions usually fail to improve the brain function. Then antenatal interventions become urgent to protect the brain,taurine has appeared a high practical value in improving the brain development. The adverse effects of IUGR on fetal brain develop-ment and the possibilities of antenatal interventions were introduced in this paper in order to improve the prognosis of the nervous system.