OBJECTIVE: To study the clinicopathologic features, immunophenotype, diagnosis and differential diagnosis of Sinonasal teratocarcinosarcoma (SNTCS). METHOD: The clinical findings, morphologic features and immunohistochemical markers in one case of SNTCS were studied, and the relevant literatures were reviewed. RESULT: The Tumor tissue is composed of three layers, with mature and immature squamous epithelium nests, neural epithelial cells and olfactory neuroblastoma-like cells derived of ectoderm; Sarcomatoid components and bone tissue derived of mesoderm; The glandular and tubular structures part of which is adenocarcinoma and respiratory epithelium derived of endoderm; The fetal clear cell squamous epithelium is typical. In addition, diffuse large cytoplasm-with high light and cytoplasm with dark light has no obviously boundery. Immunohistochemical staining showed immune markers of different germ layers corresponding, squamous epithelium, glandular epithelium and respiratory epithelium were positive for CK and EMA, neural epithelial cells and olfactory neuroblastoma-like cells were positive for S-100, NSE and Syn, sarcomatoid area was positive for Vim, light dye area was positive for Vim, CD99 and CK, dark area was positive for NSE and GFAP. CONCLUSION SNTCS is a rare malignant tumor with the features of teratoma and carcinosarcoma, its histopathological and immunohistochemical features were typical, should be more drawn and sliced to avoid misdiagnosis and missed diagnosis.
Adenocarcinoma ; Carcinosarcoma ; diagnosis ; immunology ; pathology ; Diagnosis, Differential ; Esthesioneuroblastoma, Olfactory ; diagnosis ; immunology ; pathology ; Humans ; Nasal Cavity ; Nose Neoplasms ; diagnosis ; immunology ; pathology ; Teratoma ; diagnosis ; immunology ; pathology

The blood vessels of the adrenal gland of 28 fetuses and newborns were studied in this work. Three methods, the injection replication of the microvasculature for scanning electron microscopy, the injection of ink for light microscope and lead latex injection for gross anatomy, have been used. The superior, middle and inferior arteries of the adrenal gland originate from the inferior phrenic artery, abdominal aorta and renal artery respectively. They branch into fin- er arteries when they reach the surface of the gland and run through the capsule of the gland. The finer arteries divide into branches beneath the capsula of the gland. Some of the ultimate branches divide into capillaries and form the subcapsular plexus proper. Others enter directly into the adrenal cortex and medulla separately. They are named the cortical arteries and medullary arteries. Looped cortical arteries run into the cortex from subcapsular plexus, and return to the subcapsular plexus and supply it with blood. We call them the "V" type arteries. The subcapsular plexus gives off numerous capillaries that form the adult cortical capillary plexus which supplies, in turn, the fetal cortex capillaries with blood. The cortical arteries give off the capillaries to supply blood to the fetal cortex. These two kinds of the capillaries form the fetal cortical capillary plexus. In the middle of the fetal cortex the capillaries converge into small veins which run centripetally. Some of them form the first order branch of the central vein. Others break up into the capillaries near the central region. These capillaries converge into the small venous channels which drain into the central vein. This form of vessels is named the "portal vessels". Medullary cells migrating in the cortex are supplied with blood by the medullary arteries proper. The small veins converge gradually to form a treelike pattern and finally drain into the central vein which emerges as the adrenal vein on the anterior surface of the gland. The right adrenal vein drains into the vena cava inferior and the left one into the renal vein. Adrenal arteries are accompanied by the corresponding veins. The superior adrenal vein drains toward the inferior phrenic vein. The middle adrenal vein drains into the adrenal vein, and the inferior one into the renal vein.

TRP(transient receptor potential) ion channel is a kind of membrane proteins which are widespreadly present in various cells,which is used to identify various mixed flavor and warm,heat,cold,and other temperature.Originally cloned as a proatate-specific protein.TRPM8 is now best known as a cold-and menthol-activated channel implicated in thermosensation.We provide a brief review of current knowledge concerning the biophysical properties,gating mechanisms,pharmacology and(patho)physiology of this TRP channel.

ObjectrueTo evaluate magnetic resonancec ho langiopancreatography (MRCP) in the diagnosis of acute or chronic pancreatitis . MethodsMRCP was undertaken in 30 patients with chronic and 9 with acute pancreatitis. Comparison was m ade with findings at ERCP.ResultsOf 196 segments of biliary-pancreatic duct analyzed, 17 were not seen at MR CP (sensitivity, 91%). Of the segments visualized at MRCP, 14 were incorrect ly characterized (accuracy, 92%). At MRCP, segments not detected or mischara cterized were either normal, slightly dilated, or narrowed. MRCP image quali ty was not interpretable in two cases due to artifacts. ConclusionVery good correlation between ERCP and MRCP findings was demonstrated. MRCP may substitude for ERCP, particularly in pa tients who cannot undergo ERCP or in whom ERCP has been unsuccessful.

The more and more application of assistive technology in special education not only makes education placement of student with disability diversification, but also provides more opportunity for them to participate in instruction. However, there are some problems remained, such as the application is still in low level, the lack of the systematic evaluation for their efficacy and so on. It is necessary to pay more attention on the assistive technology, cultivate more specialists and other related persons on assistive technology, create assistive technology system, and perfect the service system.

Acupuncture Therapy ; Adolescent ; Adult ; Female ; Humans ; Lumbosacral Region ; injuries ; Male ; Middle Aged ; Moxibustion ; Sprains and Strains ; therapy ; Young Adult

Objective:To investigate the association between the C1GALT1 rs1008898,the DEFA rs2738081 polymorphisms and susceptibility to IgA nephropathy in Chinese Han and Hui population in area of Gansu Province and explore molecular markers to predict IgA nephropathy Methods: In this study,there were 146 patients with IgAN and 180 normal controls in Han people and 83 patients with IgAN and 100 normal controls in Hui people.Two SNPs as rs1008898 and rs2738081 were analyzed with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and polymerase chain reaction-gene sequencing technology.The genotype and allele frequency of rs1008898 and rs2738081 were compared between patients with IgAN and normal controls.Results: Rs1008898 GG genotypes and G allele were over represented in IgAN patients compared with controls.Distribution of rs1008898 polymorphism in patients with IgAN and normal controls showed no difference in Hui people.Neither Han nor Hui population,rs2738081 polymorphism had difference between IgAN patients and normal controls.Conclusion: The G allele of rs1008898 probably has correlation with the genetic susceptibility of IgAN in Gansu Han people.

Objective To observe the expression levels of PI3K ,ERK ,IGF‐1R and ER in cervicitis and cervical squamous cancer tissues among Uighur and Han ethnic patients and their correlation .Methods The 90 paraffin embedding samples of cervici‐tis tissue( 46 cases for Han and 44 cases for Uighur) and 224 paraffin embedding samples of cervical squamous cancer tissue (36 ca‐ses for Han and 188 cases for Uighur) were collected and detected the protein expression levels by using immunohistochemistry .Re‐sults The positive expression rates of IGF‐1R and PI3K in cervical squamous cancer were 58 .04% and 92 .41% respectively ,which were higher than 13 .33% and 57 .78% in cervicitis tissue ,the positive expression rates of ER and ERK in cervical squamous cancer were 22 .32% and 68 .30% respectively ,which were lower than 63 .33% and 95 .56% in cervicitis tissue ;the positive expression rate of IGF‐1R and PI3K of cervical squamous cancer in Han and Uighur were 69 .44% ,88 .89% and 55 .85% ,93 .09% respective‐ly ,which were higher than 15 .22% ,54 .35% and 11 .36% ,61 .36% of cervicitis tissue ;the positive expression rate of ER and ERK of cervical squamous cancer in Han and Uighur were 13 .89% ,83 .33% and 23 .94% ,65 .43% respectively ,which were lower than 65 .22% ,93 .48% and 61 .36% ,97 .73% of cervicitis tissue respectively ;the expression of ERK in Uighur cervical squamous carci‐noma tissue was 65 .43% ,which was lower than 83 .33% in Han ,the difference was statistically significant (P<0 .01) .Conclusion PI3K ,ERK ,IGF‐1R and ER protein expression positive or deficiency is closely related to the occurrence of cervical cancer ,which may serve as the important biological indicators for detecting cervical cancer ,and the ethnic difference of ERK protein expression exists in cervical cancer .

Asthma ; drug therapy ; metabolism ; Cytokines ; metabolism ; Drugs, Chinese Herbal ; pharmacology ; therapeutic use ; Humans ; Inflammation Mediators ; metabolism ; Phytotherapy ; Signal Transduction