Objective To explore the method and effect of self-management of the peripherally inserted central catheter (PICC) among hematonosis patients out of the hospital. Methods A total of 138 hematonosis patients with the PICC were divided them into the experimental group and the control group, 69 patients repectively. The patients as well as their family members in the experimental group were trained how to maintain the PICC, while for the control group, we gave patients regular nursing. The maintaining situation of the PICC in each group were observed. Results There was no significant difference in the experimental group and the control group in terms of the complicating disease and the lasting period of the PICC. Conclusions The training of self-management out of the hospital of the PICC towards the patients as well as their family members not only provides convenience for patients, decreases their expense, guarantees the health education, but also enhances patients' ability to look after themselves in everyday life and improve their life quality.