OBJECTIVE: To provide references for the improvement of drug safety of emergent public health events.METHODS: The characteristics of drug demands in emergent public health events were analyzed to guarantee the characteristics of drug safety so as to explore effective safeguard strategy.RESULTS & CONCLUSIONS: Special system and countermeasure are required to guarantee drug safety of emergent public health events.The strategy includes three aspects,i.e.adequate plan in advance,rapid response and timely consummation after the event.

The pathogenesis of migraine is not fully understood as yet. Recently, with the development of ultrasonography, some stud-ies indicated that the prevalence of right-to-left shunt (RLS) seemed to be higher in migraine, especially in migraine with aura. The progress in the relationship between migraine and RLS was reviewed.

Objective To evaluate spiral CT scanning and CT virtual endoscopy(CTVE) in the clinical diagnosis of gastric carcinoma.Methods Spiral CT scan was performed in 28 patients with pathologically-proved gastric cancer . The CT scan parameters were : collimating width 5 mm , Pitch 1 . The volumetric data were acquired using a spiral CT scanner and transferred to computer workstation . CTVE was performed by navigator smooth function . The results were compared with the findings of fiberoptic endoscopy and/or surgery .Results Spiral CT scan could demonstrate the location ,size,extension of lesions and the relation with organs around .In 28 patients,CT findings included omentum involvement(n=7),pancreatic ivolvement (n=4),hepatic involvement (n=3),lymph node metastasis(n=3). CTVE could clearly demonstrate the three-dimensional image of normal wall stomach and the lesions , size and extension of lesions . The appearances of the inner lesions and normal wall of stomach on CTVE were similar to those on fiberoptic endoscopy and/or surgery . The accuracy in detecting lesion by CTVE was 92.8% in 28 patients . Conclusion CTVE combination with spiral CT scan is of great value in clinical diagnosis of gastric carcinoma .

Objective To evaluate the diagnostic value of spiral CT and all kinds of 3D reconstruction in pulmonary tuberculosis .Methods 145 cases of pulmonary tuberculosis confirmed by clinical study and histopathology were analyzed retrospectively. All cases weregiven to helical scan and different cases were given to different 3D reconstruction (CTVE, MPR and CPR) .Results Spiral CT (HRCTespecially) could find many signs of pulmonary tuberculosis, such as centrilobular distribution nodules, tree-in-bud, cavitations,tuberculous pneumonia, miliary nodules, branchogenic dissemination, endobranchial tuberculosis, lymph node enlargement and calcification. The accuracy of spiral CT in the diagnosis of pulmonary tuberculosis was 96.6%, The accuracy of spiral CT with 3Dreconstruction in the diagnosis of pulmonary tuberculosis was 99.31%.Conclusion Pulmonary tuberculosis can be diagnosed accurately by spiral CT with all kinds of 3D reconstruction.

BACKGROUND:In the treatment of early caries, fluoride can be used for remineralization of white spot lesions. Varnish XT (durable fluoride-releasing coating) and ICON penetration resins are two new materials. Varnish XT as a new type of resin reinforced glass ionomer can be selected as mineralized material. ICON penetration resin is a high-permeability resin with good liquidity that can infiltrate by capilary action into the pores created by enamel demineralization. Low-viscosity resin is used to replace the lost hard tissue due to demineralization and occupy the micropores, so as to fil the region of enamel demineralization and prevent further development of lesions. OBJECTIVE:To study the effects of two minimaly invasive surgical treatment materials, Varnish XT and ICON penetrating resin, on the microhardness of enamel caries white spot. METHODS:Totaly 100 incisors of cows were selected, embedded with ethoxyline resin and polished. The lip side facing down served as the observation side. An area of at least 6 mm×10 mm on the enamel face was exposed, and there were five regions from incisal to dental cervix, A, B, C, D, E. After demineralization liquid for artificial caries, no treatment was adopted in region A, treatment with Varnish XT was for region B, treatment with ICON penetrating resin for region C, treatment with fluoride for region D, and region E was sealed with antacid nail. Surface micro-hardness was detected. RESULTS AND CONCLUSION: After demineralization, surface micro-hardness of regions A, B, C, D decreases remarkably as compared with region E (P < 0.05). Surface micro-hardness of regions B, C, D was higher than that of region A, and ranged as folows: C > B and D for surface micro-hardness with statistical significance (P < 0.05). There was no statistical significance of surface micro-hardness between regions B and D (P > 0.05). ICON resin infiltration, Varnish XT and fluoride have obvious improvement effects on surface micro-hardness, and ICON resin infiltration is superior to Varnish XT and fluoride.

Acute Disease ; Adult ; Female ; Herbicides ; poisoning ; Humans ; Male ; Middle Aged ; Paraquat ; poisoning ; Retrospective Studies ; Young Adult

Objective: To study the anticancer and antioxidative effect of selenium and survival time in mice with tumor. Methods: According to body weight, the mice with S180 and ECS tumor(half in male and female) were randomly divided into group NS and group selenium. The inhibitory rate?survival time, serum and liver glutathion peroxidase(GSH-Px)?superoxide dismutase(SOD) and malondialdehyde(MDA) were studied. Results: The inhibitory rates on S180 and ECS in group Se were significantly higher than those of the NS group(P

Clinical features of 2 cases of ectopic ACTH syndrome with manifestation of severe hypercortisonism are described with the aim of exploring effective therapies.

Invasion of glioma is a complex process with multiple steps and multiple factors,including the inhibition of tumor cell adhesion,the degradation of extracellular matrix,the promotion of tumor cells migration and angiogenesis.The abnormal activation of Wnt/β-catenin signaling pathway is closely related to the invasion of glioma.The study of Wnt/β-catenin pathway affecting invasion mechanism of glioma will provide new ideas and targets for the treatment of glioma.

The roles of pharmacists in clinical trials including GCP training , drug administration , evaluation of drug safety issues in clinical trials and regimen design etc were discussed and prospected in the paper .The roles of pharmacists are decisive , and they will play more important roles in clinical trials .