Objective To analyze the characteristics and diagnosis of children aged

Asthma ; psychology ; therapy ; Humans ; Integrative Medicine ; Stress, Psychological

Objective To investigate the value of diffusion tensor tractography (DTT) quantitative assessment of corticospinal tract (CST) damage in acute intracerebral hemorrhage (ICH). Methods Thirty-two patients were enrolled in this study. DTT was obtained in early stage of ICH. The CST was reconstructed with Volume One 1.64 and diffusion Tensor Visualizer (dTV) software from Tokyo University. The compression, the displacement, the destruction, and the relative remaining number of the CST were calculated. Results The compression, the displacement and the destruction of the CST were observed in DTT images in all patients. The correlation coefficient between remaining number of the CST and score of Fugl-Meyer after the onset of ICH was 0.75 (P＜0.01). Conclusion DTT can quantitatively evaluate the state of CST injury in acute ICH.

Objective To observe the regulatory effects of the preventive acupuncture and moxibustion at Guanyuan (RN4) points in ovariectomized rats, and discuss the mechanism of preventive acupuncture and moxibustion on hyoathalamus-pituitary-ovary (HPO) axis. Methods Totally 48 female SD rats were divided into 5 groups, including normal group, sham operation group, ovariectomized rats group, preventive acupuncture group and preventive moxibustion group. Except normal group and sham operation group, rats were ovariectomized after preventive acupuncture and preventive moxibustion for 30 d in corresponding groups. ELISA was used to determine the levels of E2, ER, GnRH, FSH and LH in the tissues including hypophysis, hypothalamus and uterus. Results Compared with the normal group, E2, ER and GnRH level in the tissue of the model group was significantly lower (P<0.01), the levels of FSH and LH increased obviously (P<0.01). Compared with the model group, E2, ER and GnRH level of preventive acupuncture group and preventive moxibustion group increased in different degree (P<0.05). FSH and LH level reduced in different degree (P <0.05). There was no obvious difference between preventive acupuncture and preventive moxibustion group (P>0.05). Conclusions The preventive acupuncture and preventive moxibustion at Guanyuan (RN4) has benign modulation to disordered HPO axis of ovariectomized rats. The ability of preventive acupuncture and preventive moxibustion are almost the same.

Adolescent ; Basal Ganglia Diseases ; Calcinosis ; Child ; Female ; Humans ; Pedigree

Antenatal corticosteroid administration to women at risk of preterm delivery within 34 gestational weeks can effectively reduce the incidence of respiratory distress syndrome, intraventricular hemorrhage, and necrotizing enterocolitis in preterm infants. Due to concerns that antenatal corticosteroids may impair the development of the newborn's nervous system, there is a controversy regarding the use of antenatal corticosteroids in pregnant women ≥34 gestational weeks and those with complications. This article reviews the short- and long-term effects of antenatal corticosteroid administration on the nervous system of neonates born to women at different gestational ages and with comorbidities. More and higher-quality evidence is required for routine application of antenatal corticosteroids in pregnant women ≥34 gestational weeks.

Objective To analyze correlation of drug with acute drug-induced liver injury in 83 patients. Methods According to the international consensus criteria and Danan's causality assessment of a drug in the case of acute liver injury, 83 cases which had been clinically diagnosed as acute drug-induced liver injury were analyzed. Results Among the 590 inpatients of acute hepatitis, 83 (14.07%) were acute drug-induced liver injury, in whom 53 patients had liver cell damage (63.86%), 22 with cholestasis (26.5%), and 8 with mixed type (9.64%). In 34 patients, it was drug related (40.96%), undefined in 37 cases (44.57%), and unrelated in 12 cases (14.47%). Conclusion The international consensus criteria standardized the diagnosis of drug-induced liver injury and are helpful in differential diagnosis, but it needs improvement for actual implementation.

Objective To study the characteristics of organ function and structural injuries in the elderly with multiple organ dysfunction syndrome. Method 50 Wistar rats (25 three-month-old rats and 25 twenty-month-old rats) were anaesthetized and experienced cecal ligation puncture (CLP) operation, which were defined as MODSE group and MODS group respectively. 40 Wistar rats (20 three-month-old rats and 20 twenty-month-old rats) were anaesthetized and not experienced cecal ligation puncture operation, which were used as SOGE (sham operation group in the elderly) and SOG (sham operation group). At 6 h, 12h, 24h, 48h or 72h after operation, serum levels of alanine aminotransferase, aspartate aminotransferase, blood urea nitrogen, creatinine and total bilirubin were measured by automatic biochemistry analyzer. Organs (hearts, brains, lungs, livers, kidneys) were harvested. Paraffin sections were made and stained by conventional H.E procedure for histological examination. Results Based on histological investigations, physiological and biochemical measurements, organ dysfunction in MODSE group occurred at 6h after operation and peaked at 24 h after operations. Otherwise, organ injuries with MODS occurred at 24 h and peaked at 48 h after operation. Conclusion According to histological investigations, physiological and biochemical measurements, damages of organ dysfunction and structural damages in MODSE group occurred much earlier and more seriously. which may provide an experimental evidence for medico-legal certification of the death caused by MODS.

Purpose:To evaluate the clinical effect of late-course hyperfractionated (LCH) radiotherapy and conventionally fractionated (CF) radiotherapy for local advanced non-small cell lung cancer (NSCLC). Methods:From August 1995 to April 1998, 74 patients with inoperable stage Ⅲ NSCLC were randomized into two groups: CF and LCH. 37 patients in CF group received a fraction of 2 Gy daily, 5 days per week, to the total dose of 65～70 Gy /6.5～7 weeks. 37 patients in LCH group were treated with the same fractionation as CF group to the dose of 40 Gy, and then followed by LCH radiotherapy: 1.2Gy, twice daily, with the interval of 6 hours between fractions, to the total dose of 64 Gy/6 weeks. Results:The overall response rate in LCH group and CF group were 78.4%(29/37) and 62.2%(23/37) respectively, the difference was significant (P

[Objective]To evaluate the initial effect of the computer-assisted total knee replacement system.[Method]The 24 computer-navigated knees in our department were involved,and were matched at ratio of 1∶3 by previous cases at sex,age and disease.All cases anteroposterior and lateral projection X-ray films were checked postoperatively.We compared ? and ? angles at anteroposterior films,? and ? angles ant lateral films of all involved cases[Result]Although there was no significant differences existing between two groups,we still observed the obvious reduce risk of malplacement both for femoral and tibial prosthesis,and improvement of mechanical alignment.[Conclusion]By using computer-navigated total knee replacement system during operating,the precise and repeatability could be ensured.