GCC/PKG/VASP,PKA/VASP et.al are associated with the occurrence and development of colorectal cancer.As one of the important signaling molecules of above signal pathways,VASP has constributed to the invasion,metastasis,apoptosis,angiogenesis and other events of colorectal cancer.The role of VASP signaling pathways in the development of CRC and its potential clinlic significance are reviewed in this article.

OBJECTIVETo assess the values of diffusion weighted imaging and contrast-enhanced magnetic resonance imaging (MRI) in the evaluation of early endometrial cancer.

METHODSWe retrospectively analyzed the imaging data of 27 patients with pathologically confirmed stage 1-2 endometrial cancer. These patients received pelvic magnetic resonance imaging, diffusion weighted imaging with apparent diffusion coefficient-T2 weighted imaging fusion images(ADC-T2WI), and T1 weighted imaging (T1WI) of contrast-enhanced scan sequence. The accuracies of these image modes were analyzed and compared.

RESULTSThe accuracy of routine pelvic MRI scan, diffusion weighted imaging with ADC-T2WI fusion images, and T1WI of contrast-enhanced scan for the early diagnosis of endometrial cancer was 66.7%, 85.2%, and 92.5%, respectively. The sensitivity, specificity and diagnostic accuracy of diffusion weighted imaging with ADC-T2WI fusion images in the diagnosis of lesions with a 1/2 depth of muscle were 82.3%, 75%, and 85.2%.

CONCLUSIONSRoutine pelvic MRI scan sequence has certain errors for the early diagnosis of endometrial cancer. On the contrary, the diffusion weighted imaging with ADC-T2WI image fusion has remarkably increased diagnostic accuracy. The T1WI of contrast-enhanced scan can clearly display most of the lesions by identifying the muscular infiltrations, and therefore can provide the most accurate information for the staging of early endometrial cancer.

Adult ; Aged ; Contrast Media ; Diffusion Magnetic Resonance Imaging ; methods ; Endometrial Neoplasms ; diagnosis ; pathology ; Female ; Humans ; Magnetic Resonance Imaging ; methods ; Middle Aged ; Neoplasm Staging ; Retrospective Studies ; Sensitivity and Specificity

ObjectiveTo explore the determinants of average length of stay of three county hospitals and eleven countryside hospitals of Xinjiang province.MethodsRelative data of the county and the countryside hospitals from 2009 to 2010 were collected,and descriptive analysis and rank sum test were employed to explore the determinants of average length of stay.ResultsThe average length of stay of the county hospital was longer than the countryside hospital,the average length of stay had significant differences between the gender,age,and the disease classfication.ConclusionThe average length of stay of the county hospitals and countryside hospitals had difference significantly.