The article submitted the new progress of the study in antitumor mechanism of bererine (Ber). Reports indicated that Ber suppressed growth of tumor cells through impacting tumor cells growth cycle, inhibiting synthesises of DNA and protein, and reducing the activity of topoisomerase. Ber improved tumor cells apoptosis through several ways such as regulating apoptotic gene expression, inducing the decline of transmembrane potential on mitochondria. And Ber still could inhibit tumor metastasis through suppressing the formation of tumor angiogenesis, blocking signal transduction pathway, antagonizing extralumen, et al. In addition, Ber could induce tumor cells to differentiate to antagonize tumor.
Animals ; Antineoplastic Agents, Phytogenic ; isolation & purification ; pharmacology ; Berberine ; isolation & purification ; pharmacology ; Cell Line, Tumor ; Cell Proliferation ; drug effects ; DNA, Neoplasm ; biosynthesis ; Humans ; Neoplasm Proteins ; biosynthesis ; Neoplasms ; genetics ; metabolism ; pathology ; Plants, Medicinal ; chemistry