Intracranial arterial stenosis is the most common vascular lesions in patients with acute stroke in Chinese population,and most of them are middle cerebral artery (MCA) stenosis.The treatment of asymptomatic MCA stenosis is mainly to control the risk factors and treat with drugs,and the prognosis is better.Statins can reduce new stroke events.The treatment programs of symptomatic MCA stenosis are mainly to control the risk factors,treat with drugs and stenting.Now it is considered that anticoagulants are not superior to antiplatelet drugs in the treatment of MCA stenosis,but whether dual antiplatelet drugs are superior to monotherapy and stenting remains to be determined.The prognosis of symptomatic MCA stenosis is poor.The prognosis of acute phase mainly depends upon imaging features,and the risk of recurrent stroke is primarily associated with the MCA stenosis.Future research should focus on whether dual antiplatelet therapy is superior to monotherapy,and whether stenting is superior to drug treatment,as well as the relationship between the degree of MCA stenosis and prognosis of acute phase or the risk of recurrent stroke.

This study is based on the application of the medical simulator and the multimedia technology to the medical English teaching for overseas students during their clinical practice in surgical department.It shows that this teaching model is effective by delivering a good studying surroundings and various language carriers.

Acute Disease ; Humans ; Pulmonary Embolism ; therapy

Objective To assess the courses of evidence-based medicine among graduate students. Methods A sample of 118 graduate students who took the course were surveyed twice by using the same self-designed questionnaire at the beginning and the end of the course.Pre-post comparison was conducted to measure the impact. Results The students were able to grasp the most of the contents of the course,and reshaped their opinions on evidence-based medicine,with which,a positive impact on their medical practice was expected. Conclusion The course of evidence-based medicine for graduate students has resulted in a positive consequence.

Animals ; Atherosclerosis ; etiology ; metabolism ; Gene Expression Regulation ; Humans ; Lipase ; analysis ; genetics ; physiology ; Lipoproteins ; metabolism ; Lipoproteins, HDL ; metabolism ; Lipoproteins, LDL ; metabolism ; Polymorphism, Genetic ; Tissue Distribution

Abstract Objective:To investigate whether mRNA of prolactin(PRL) ,an important immunomodulatory hormone,is expressed in thyroidglands of patients with Graves'disease(GD) .Methods:The expression of PRL mRNA was examined by nonisotopic in situ hybridization in GDthyroid glands and the control ones( including multinodular goiters and samples of normal thyroid tissue adjacent to adenomas) as well as intra-thyroidal mononuclear cells isolated from GD thyroid glands and primary thyroid follicular cell(TFC) cultures derived from them.Results:PRL mRNA was expressed in GD thyroid glands, but not in the control ones. It was localized in infiltrating mononuclear cells and vascular endothelial cells adjacent to mononuclear cell infiltrates, but not in TFC .(9.8?.3)% (x ?s) of intrathyroidal mononuclear cells isolated from GD thy-roid were found containing PRL mRNA.It was absent in the primary TFC cultures. Conclusion:PRL mRNA is expressed in GD thyroid tissue. This indicates that PRL-like substance can be locally produced in GD thyroid tissue, which may play an important role in GD pathogenesis by autocrine and paracrine mechanisms.

s:Objective To investigate the critical value of neonatal coagulation and the normal reference range in clinical prac-tice,and make Value of the formulation of clinical treatment programs and prevention of neonatal blood coagulation disor-ders.Methods Collected neonatal specimens of 350 cases from January to June 2016 in the General Hospital Ningxia Medi-cal University,after birth with in 6h,the parameters of plasma coagulation:activated partial thromboplastin time (APTT), prothrombin time (PT)clotting time (TT)and fibrinogen (FIB).Made statistics and analysis of all critical information to improve the value of the cases after contact with the telephone registration of neonatology,and critical investigation occurred gestational age children value,birth weight,and critical analysis of the proportion of the value of the proj ect,the distribution of the disease,clinical response and so on.Results Compared with adults and children,four indexes of coagulation levels of newborn were significantly different (t=1.66~2.66,P<0.01),as well as preterm group and term group;additional chil-dren with severe and premature birth or low weight occurs critical the possibility of greater value,and the distribution of high APTT and low FIB profile occured in the most critical values,neonatal jaundice and severe pneumonia was a risk factor critical values outbreak.Overall clinical response rate was 33%,the“answer”and“non response group”in children with in-tracranial hemorrhage of digestive and tract,and the diagnosis rate of statistical results was no significance (χ2=36.68/39, P>0.05).The range of personal critical value of the newborn infant was intended to develop:PT(≤8 s and≥30 s),APTT (≤20 s and ≥90 s)and FIB(≤0.6 g/L and ≥10 g/L).Revised “response rate”,clinicians have increased attention com-pared with the previous increase,reducing the false critical value report incidence.Conclusion The indicators of neonatal co-agulation were different from the adults and children.For the establishment of neonatal blood coagulation parameters refer-ence range,on a regular basis to summary on the clinical data of blood coagulation critical value,and contribute to the devel-opment of suitable critical value standard,and improve the clinical comprehensive diagnosis and treatment level.

The application of MOOCs (massive open online courses) in internal medicine education is feasible with the construction of MOOCs in internal medicine, internet and mobile terminal availability, and the improvement of college student quality. We reviewed the progress of MOOCs in the medical teach-ing. The chapter of coronary heart disease was exemplified to illustrate how to apply MOOCs in internal medicine teaching. The MOOCs was carried out with the following steps: the share of MOOCs courses, self-guided learning, online question and answer section, in-class teaching and exams post MOOCs, which achieved good teaching effect, enhanced students' subjectivity, and promoted the sharing of high-quality medi-cal teaching resources. At the same time, in view of the limited nature of MOOCs in internal medicine, we need to overcome it in the development of teaching practice.

Objective To explore microRNA (miRNA) expression patients with β-thalassemia major.Methods MiRNA differential expression were detected in β-thalassemia major by miRNA microarray analysis and quantitative real-time PCR.Results The results of miRNA array showed that 26 differential expression miRNAs were up regulated and 30 differential expression miRNAs were down regulated.Hsa-miR-618 which expression was up regulated and hsa-miR-103a-2-5p which expression was down regulated were selected for quantitative real-time PCR detection.It was showed that the expression tendency of hsa-miR-618 and hsa-miR-103a-2-5p were consistent.So the method of miRNAs array was reliable.The target genes of 17 miRNAs which were up regulated and 24 miRNAs which were down regulated were predicted by using database software.Conclusion It is notable that the differential expression of miRNAs in patients with β-thalassemia major.It will be afforded new direction and thinking for the mechanism research and disease treatment through the further research of the miRNAs regulation pathway in β-thalassemia major.

Objective To establish a HPLC method for the assay of Dehydroandrographolide in Fufang Kumu Xiaoyan Pian. Methods Standard was Dehydroandrographolide, HPLC was used with Agilent ZORBAX SB-C18 column (4.6 mm?150 mm, 5 ?m). The mobile phrase was consisted of acetonitrile-0.1% Ammonia slution (30∶70). The detection wavelength at 253 nm. The flow rate was 1 mL/min. Results The assay displayed good linearity. The linear range of ephedrine Hydrochloride was 0.049 92~4.992 ?g (r =0.999 9, n =7). The average recovery was 99.70% and RSD was 0.63% (n =9). Conclusion This method is simple, accurate and can be used for the quality control of Fufang Kumu Xiaoyan Pian.