Lysine specific demethylase 1( LSD1) is a kind of flavin adenine dinucleotid ( FAD) dependent amine oxidase and can specifically demethylate H 3K4me2/me1 and H3K9me2/mel, thus it can regulate gene transcriptional activity .LSD1 is essential for mammalian development and is involved in many biological proces-ses,including cell differentiation,gene activation,and gene repression.Nowadays,it is demonstrated that LSD1 might promote cell phase transition(deficiency in LSD1 leads to partial cell cycle arrest in G2/M)and cell prolif-eration,suggesting that the over -expression of LSD1 might promote tumorigenesis.LSD1,as a demethylase,may be a new target for anti -cancer therapy.Hereby,we review on the structure,action mode of LSD1 and its rela-tionship with oncogenesis .

The introduction of research study in the course of biochemical engineering is discussed in the essay both in theory teaching and practice period to cuhivate the students'ability of self-development and innovation

As an inevitable outcome of industrialization and modernization,fashion has already underlined and comprised our daily life.No matter it is fashion of substances,concepts or behaviors,all of them are crashing against the traditional ethics value system.Its unique characteristic tries to overthrow the traditional behavior mode and cognition mode,reflecting individual's abnormal sense of value.Fashion is a two-blade sword.On the one hand,it brings both society and individuals with positive ethical effect.On the other hand,it also leads to the popularity of consumerism,corroding people's spiritual world.Morality can be used as a guide and model of fashion,and fashion can also be used for decorating morality.To avoid dull preaches is the key to balance the mutual relationship between morality and fashion.

OBJECTIVE:To discuss about the development strategy of pharmaceutical enterprises in our country in the new century.METHODS:To expound the developing strategy that domestic pharmaceutical enterprises should adopt in respect to technical innovation,development of product,exploitation of market,human capital and enterprise culture.RESULTS & CONCLUSION:Facing the new management environment,the pharmaceutical enterprises in our country should achieve new breakthrough in development strategy to adapt to trend of the times,grasp opportunity and face challenge.

Objective To study the change and its application of the brain stem auditory evoked potentials (BAEP) in language -impaired children. Methods We used evoked potentials Denmark Wedy Keypoint device to analysis the BAEP test results of the 79 cases of children in our hospital from August 2006 to December 2008. Rsults The total rate of BAEP abnormalities in children was 64.6% , of which 15.7% for one of the bilateral BAEP wave disappeared, 11.8% for the unilateral BAEP wave disappeared with the other side of the wave being abnormal BAEP,and 72.5% for the wave latency (PL) and wave interphase (IPL) abnomal. Conclusion BAEP is a sim-ple, noninvasive, threshold stability, results reliable and reproducible method of examination. For language -impaired children of hearing damage and abnormal neural pathway ,it can provide valuable objective indicators.

Objective To study the application value of laparoscopic uterine artery occlusion and uterine myomectomy for uterine myo-mas. Methods The data of 80 patients with uterine myomas in our hospital from January 2011 to January 2015 were studied. They were ran-domly divided into control group and observation group,40 cases in each group. The patients in control group received the laparoscopic myo-mectomy and the patients in observation group were treated by uterine artery occlusion and myomectomy. The hospitalization time,blood loss, disease incidence and recurrence between two groups were compared and analyzed. Results There was no statistically significance in aver-age operative time between two groups(P>0. 05). The exhaust time and hospital stay time in observation group were significantly shorter than those in the control group,the difference were statistically significant(P<0. 05). The blood loss in the control group(145. 2 ± 35. 5) mL was significantly higher than that of observation group(50. 8 ± 21. 6) mL,the difference were statistically significant(χ2 =14. 367 5,P=0. 000 0). The improved rate of postoperative menorrhagia in observation group was 100%, the control group was 25%,the differences were statistically significant(χ2 =4. 599 6,P=0. 032 0). There was no postoperative morbidity and recurrence in observation group. The postoperative morbidi-ty and recurrence rate in the control group were 5 cases (12. 50%) and 11 cases (27. 50%) respectively,the differences between two groups were statistically significant(P<0. 05). Conclusion Laparoscopic uterine artery occlusion combined with uterine myomectomy can reduce blood loss,shorten hospital stay time,reduce postoperative complication and recurrence of uterine myomas.

Objective To evaluate the clinical value of plasma procalcitonin and D-dimer measurements in estima-ting the prognosis of patients with sepsis.Methods According to prognosis,68 patients with sepsis were divided in-to survival group and death group,levels of procalcitonin and D-dimer,and acute physiology and chronic health eval-uation II (APACHE II)of two groups of patients were compared,predictive value of above markers in estimating the prognosis of patients with sepsis were evaluated.Results Of 68 patients with sepsis,28 survived and 40 died, mortality was 58.82%.There were significant differences in levels of procalcitonin and D-dimer,as well as APACHE II between two groups(both P<0.05),death group were all higher than survival group.Procalcitonin and D-dimer level were positively correlated with APACHE II score(P<0.05).Conclusion Procalcitonin,D-dimer level and APACHE II score can be used to evaluate condition of patients with sepsis as well as the prognosis of dis-ease.

Objective To observe the value of electroneurograms and sympathetic skin response (SSR) in diagnosing diabetic peripheral neuropathy( DPN). Methods The electroneurophysiological data on 36 patients with DPN, including motor nerve conduction velocity (MCV) data, sensory nerve conduction velocity (SCV) data and sympathetic skin response ( SSR) data, were analyzed retrospectively. Results Two hundred and sixteen nerves of 36 patients with DPN were inspected. Among 108 nerves tested for MCV, 32 were found to have slowed down, 8 of them with the prolongation of distal delitescence. The amplitudes of compound muscle action potential (CMAP) induced by stimulation of 4 nerves were found to have decreased. The abnormality rate was 40. 7% . Among 108 nerves tested for SCV, 42 were found to have slowed down, 7 were tested with no potential elicited, and 6 were found to have decreased SCV with the prolongation of distal delitescence. The abnormality rate was 50. 9% . Seventy-two limbs of 36 patients with DPN were inspected. Four patients showed no SSR in both their upper and lower limbs. For 38 limbs of 22 patients, the SSR latency was found to be prolonged and the SSR amplitudes were found to have decreased. The abnormality rate was 63.8% . Among 10 patients without neuropathy, 3 patients' SSR was found to be abnormal, an abnormality rate of 30% . Conclusion Electroneurograms and SSR are sensitive indices for the diagnosis of DPN. Their diagnostic sensitivity can be improved if all the parameters are used together.

Objective:To investigate the clinical effect of Six Ingredient Rehmanuia Decoction variation and cortial hormone for autoimmune hepatitis. Methods: 60 patients with autoimmune hepatitis were divided into two groups: the treatment grouup(30 cases) and control group(30 cases). Both the treatment group and control group were given methyl prednisolone. The treatment group was treated with hormone with the additon of Six Ingredient Rehmanuia Decoction, etc., one packet a day. The treatment courses of two groups were all 8 weeks. Results: The treatment group was superior to the control group in symptom, liver function and improvement of immune function. Conclusion: Six Ingredient Rehmanuia Decoction and a small dose of cortical hormone is effective for autoimmune hepatitis. No side effect is observed.