1.Effect of vascular endothelial growth factor and phosphoinositide 3-kinase in retinopathy of prematurity
International Journal of Pediatrics 2013;(1):91-94
Vascular endothelial growth factor can induce angiogenesis in vivo.Phosphoinositide 3-kinase signaling pathway widespreads in cells,which plays important roles in cell growth,proliferation,differentiation,and angiogenesis.The phosphoinositide 3-kinase signaling pathway can activate vascular endothelial growth factor,such as hypoxia-inducible factor-1,insulin-like growth factor-Ⅰ,nitric oxide synthaseand cyclooxygenase-2.The present studies have shown that the vascular endothelial growth factor and phosphoinositide 3-kinase signaling pathway play an important role in the retinopathy of prematurity.
2.Effects of Supplemented Wuling Sang on treatment of patients with primary hyperlipemia
Chinese Traditional Patent Medicine 1992;0(01):-
0.05). But the Wuling Sang could obviously decrease serum TG content than Simvastatin(P0.05). The adverse drug reactions were stomach discomfort(4 patiens in SWS) group, 5.71%), abdominal discomfort(2 patiens in Simvastatin group, 4.55% ) and sleeplessness(5 patiens in Simvastatin group, 11.4%) . CONCLUSION: The results show the TCM drug SWS is effective and softy on treating the patients with primary hyperlipemia.
3.Lung inflammatory injury after cardiopulmonary bypass
Journal of Medical Postgraduates 2001;14(2):164-168
Cardiopulmonary bypass(CPB) can induce systemic inflammatory response syndrome(SIRS).This review elaborated the influences of SIRS in acute lung injury after CPB.
4.Application of nicardipine induced hypotension in endoscopic sinus surgery
Chinese Archives of Otolaryngology-Head and Neck Surgery 2006;0(05):-
OBJECTIVE To investigate the advantages of nicardipine induced hypotension in endoscopic sinus surgery.METHODS Eighty patients underwent endoscopic sinus surgery under general anesthesia were randomly assigned into two groups(n=40 each):Group A(Enflurane Group), Group B (Nicardipine Group).The effect of controlled hypotension was compared between the two groups.The changes of MAP, HR were recorded during induced hypotension, the time of induction, maintenance and recovery in induced hypotension were recorded.RESULTS 1.The induced hypotension induction time in group A was significant shorter than that in group B, BP recovery time in group A was obviously longer than that in group B (P
5.Research progress of the mechanism of hepatic injury after cardiopulmonary bypass
Journal of Medical Postgraduates 2003;0(08):-
Since the first launching of heart lung bypass machine in animal model in 1937,cardiopulmonary bypass(CPB) has become more and more consummate,but it still brings about many complications,including pulmonary,renal and hepatic dysfunctions.Among these complications,hepatic dysfunction plays an important role in the impairment after cardiac operations.The liver function indices such as aspartate aminotransferase,glutamate-pyruvate transaminase,bilirubin and alkaline phosphatase will step up obviously during 3 to 5 days after the operation.The physiological changes deteriorate patient's condition,and even influence the prognosis.This clinical phenomenon puzzles cardiac surgeons.All these demand us to answer the following questions: Is the cardiopulmonary bypass harm the liver? What's the mechanism? We review the different researches on hepatic injury after cardiopulmonary bypass.
6.The protective effects of statins on organs after cardiopulmonary bypass to statins
Journal of Medical Postgraduates 2003;0(08):-
Cardiopulmonary bypass(CPB) often result systemic inflammatory response syndrome.In addition to lipid lowing effects,statins appears to exhibit pleiotropic effects such as antiinflammatory properties,improvement of endothelial dysfunction and reduction of ischemia-reperfusion injury.In this review,the author summarized advances in these respects.
7.Heat shock protein and cardioprotection
Journal of Medical Postgraduates 2003;0(09):-
The defense mechinism of heat shock protein(HSP)acting as moleculars chaperons requires heat shock transcription factors as the primary mediators of the heat shock response.Increased expression of HSP may protect the heart.Overexpression of HSP can inhibit cardiomyocyte apoptosis,protect the integrity of the microtubules and the actin cytoskeleton in cardiac myocytes and endothelial cells exposed to ischemia,participate in the folding and activation of protein kinases and transcription factors such as HIF-1? and HSF1,bind to endothelial nitric oxide synthase(Enos) and stimulate its activity,and downregulate cytokine production.Hence,it is of benefit to efficiently elevate HSP expression in myocardium using pharmacological and/or gene therapy procedures without any adverse effect.
8.Heart transplantation and myocardial preservation solution
Journal of Medical Postgraduates 2003;0(12):-
Myocardial preservation plays a critical role in heart transplantation.Recently,heart transplantation has been practiced wildly all over the world.The aim of this review is to summarize the progress in the researches on the clinical appication and experiments of myocardial preservation sotution.
9.Mechanism and preventive measures of renal injury after cardiopulmonary bypass
Journal of Medical Postgraduates 2003;0(04):-
Despite the continuous improvement of cardiopulmonary bypass(CPB),renal dysfunction remains a frequent complication of cardiac surgery.Previous studies reported that the incidence of acute renal dysfunction following CPB was 7%-40%,while that of acute renal failure(ARF) was 1%-10%.In those who developed ARF,the prognosis was poor,with mortality of about 40%-80%.The present paper reviews the mechanism,risks and available preventive measures of acute renal injury following CPB.
10.Update of the protective effect of PPAR-? ligand in myocardial ischemia-reperfusion injury
Journal of Medical Postgraduates 2003;0(04):-
With the development of coronary artery recanalization technology,more and more attention are paid to myocardial ischemia-reperfusion injury.PPAR-? is distributed in rat myocardium.Besides insulin sensitizing effect,the ligands of PPAR-? can also exert its protective effects by inhibiting cell inflammatory response and apoptosis.In this review,the author summarized the research advances of the protective effects of the ligands PPAR-? on myocardial ischemia-reperfusion injury.