Adult ; Humans ; Male ; Nitrogen Oxides ; poisoning ; Occupational Exposure

Dust ; Humans ; Inflammation ; metabolism ; Intercellular Signaling Peptides and Proteins ; metabolism ; Silicon Dioxide ; adverse effects ; Silicosis ; metabolism

Adult ; Dermatitis, Contact ; Dimethylformamide ; poisoning ; Female ; Humans

Amylases ; blood ; Herbicides ; poisoning ; Humans ; Lipase ; blood ; Paraquat ; poisoning ; Poisoning ; blood

Adult ; Female ; Humans ; Inhalation Exposure ; Male ; Middle Aged ; Paraquat ; poisoning

Adult ; Aluminum Compounds ; poisoning ; Humans ; Male ; Phosphines ; poisoning

Adult ; Burns, Chemical ; pathology ; Female ; Humans ; Male ; Middle Aged ; Paraquat ; poisoning ; Skin ; injuries

Acute Disease ; Adult ; Chlorpyrifos ; Humans ; Insecticides ; poisoning ; Male ; Organophosphate Poisoning ; complications ; Rhabdomyolysis ; chemically induced

OBJECTIVETo explore the role of sTRAIL in the pathogenesis of HBV infection in human being.

METHODSsTRAIL in 153 patients' sera was examined with ELISA. Correlations between sTRAIL and liver functional parameters were analysed.

RESULTSThe levels of sTRAIL in patients with various clinical types of hepatitis B as well as primary hepatocellular carcinoma were all higher than that in normal persons and became almost normal in recovering stage cases. In acute and chronic HBV infection, sTRAIL level was negatively correlated with ALT, AST and total bilirubin levels, and positively correlated with serum albumin.

CONCLUSIONThe results indicated that higher level of sTRAIL expression is correlated with liver damage, and apoptosis induced by sTRAIL is one of the mechanisms of liver damage in HBV infection.

Adolescent ; Adult ; Aged ; Alanine Transaminase ; blood ; Aspartate Aminotransferases ; blood ; Enzyme-Linked Immunosorbent Assay ; Female ; Hepatitis B ; blood ; Hepatitis B, Chronic ; blood ; Humans ; Liver Cirrhosis ; blood ; virology ; Liver Neoplasms ; blood ; virology ; Male ; Middle Aged ; Serum Albumin ; analysis ; TNF-Related Apoptosis-Inducing Ligand ; blood ; Young Adult

Progressive loss of retinal ganglion cells (RGCs) and their axons is the main pathogenesis of glaucoma. The cause of glaucoma is not fully understood, but the neurodegeneration of glaucoma involves many mechanisms such as oxidative stress, glutamate toxicity and ischemia/reperfusion insult. In order to target these mechanisms, multiple neuroprotective interventions have been investigated to prevent the death of RGCs. Of note are some tonic herbs from the traditional Chinese medicine (TCM) pharmacopeia that have shown neuroprotective effects in glaucoma. TCM differs from Western medicine in that TCM exhibits complicated bioactive components, triggering many signaling pathways and extensive actions on vital organs. Modern scientific approaches have demonstrated some of their underlying mechanisms. In this review, we used Lycium barbarum and Ginkgo biloba as examples to elaborate the characteristics of TCM and their potential applications in neuroprotection in glaucoma.
Clinical Trials as Topic ; Drugs, Chinese Herbal ; therapeutic use ; Ginkgo biloba ; Glaucoma ; drug therapy ; Humans ; Medicine, Chinese Traditional ; Neuroprotective Agents ; therapeutic use ; Retinal Ganglion Cells ; pathology