Objective To analyze the anesthesia effect of droperidol and pethidine hydrochloride in combina-tion with paracervical block in artificial abortion.Methods 386 patients undergoing artificial abortion were admitted. They were randomly divided into the two groups.The study group(193 cases)was treated with droperidol and pethi-dine hydrochloride in combination with paracervical block,while the control group (193 cases)was treated with droperidol and pethidine hydrochloride only.The analgesic effect,hemodynamics,cervix relaxation and side effects between the two groups were compared.Results The analgesic effect of the study group was 9 1 .7%,which was much higher than 72.0% of the control group(χ2 =25.198,P<0.01),and there were significant differences between the two groups in hemodynamics(t=4.545,3.674,all P<0.01).The total cervix relaxation were 102 cases,and partly cervix relaxation were 69 cases in the study group,which were significantly higher than that of the control group (69 cases,60 cases,respectively;Z=4.643,P<0.01).There was no difference between side effects except for abor-tion syndrome(χ2 =7.580,P=0.006).Conclusion Droperidol and pethidine hydrochloride in combination with paracervical block have an excellent effect on artificial abortion.

OBJECTIVE:To study the correlation between salivary drug concentration and blood,drug level its clinic sig-nificance.METHODS:The salivary drug concentration and blood drug level of gentamicin of15volunteer cases were deter-mined by radioimmunoassay.RESULTS:Both blood drug level and salivary drug concentration of gentamicin reached to peak level1hour after medication.CONCLUSION:The blood drug level of gentamicin and the salivary drug concentration of gentamicin are positively correlated,i.e.it is possible for salivary to substitute for blood in the therapeutic drug monitoring of gentamicin.

0.05),with the determination result of the whole blood-diluted sample more similar to that of the undiluated one.CONCLUSION:Whole blood sample of cyclosporine can be stored stably at room temperature at least for 2 weeks.Cold storage is the best storage method and blank whole blood was proved to be the best dilution solvent.

OBJECTIVE:To discuss the approach for clinical pharmacists to participate in the drug treatment.METHODS:The contents and importance for clinical pharmacist to participate in ward rounds and discuss with doctors about the optimal dosage regimen were introduced.RESULTS & CONCLUSION:A satisfactory outcome was able to be achieved through efforts of both clinical pharmacists and physicians to modify and work out a new individualized dosage regimen.Clinical pharmacists can offer direct,responsible drug-related pharmaceutical care for patients by making fully use of the related pharmaceutical knowledge they have mastered.

Objective:To investigate the principle of anesthetic management for intracranial aneurysm.Method:The anesthetic regimens of 34 cases of intracranial aneurysm were analyzed.Controlled lowering of blood pressure and protective measures for brain were implemented introperatively to prevent rapture of cerebral aneurysm and postoperative cerebrovascular spasm.Intraoperative ECG,MAP,HR,NIBP and SPO2 were monitored and the HR,MAP before and after induction phase were compare.Result:The effects of anesthesia and lowering of Bp were satisfactory,no death occurred intraoperative!y,and aneurysm ruptured m one case.The H-Rs of whole group during induction phase were not decreased as compared with those before induction phase,and the decrease of MAP was extremely significant as compared with that after induction phase.Conclusion:The effect on parts of brain should be considered when choosing narcotics and hypotensors.Perioperative brian protection could reduce the postoperative incidence rates of arterial spasm and cerebral infarction.

Breast Neoplasms ; diagnosis ; therapy ; Cervical Intraepithelial Neoplasia ; diagnosis ; therapy ; Endometriosis ; diagnosis ; therapy ; Female ; Humans ; Neoplasms ; diagnosis ; economics ; therapy ; Ovarian Neoplasms ; diagnosis ; therapy ; Uterine Neoplasms ; diagnosis ; therapy

Cervical cancer is the most common malignancy of the female genital tract. Its incidence is still increasing with lower average onset age. Mass screening should be above prevention and treatment, and three screening programs, including the optimal program, the general program, and the basic program, are currently adopted in China. Cervical intraepithelial neoplasia (CIN) , a precancerous lesion, can be confirmed by the combined use of cytology, colposcopy, and histology and then managed with standardized approach. Human papillomavirus (HPV) infection is an essential factor during the development of cervical cancer, and persistent infection of high-risk HPVs may lead to CIN and subsequently develop to cervical cancer. High-risk HPV detection can be used for screening, differentiation of the atypical squamous cells of undetermined significance/ low-grade squamous intraepithelial lesion (ASCUS/LSIL) triage, and follow-up after treatment. The modern strategy of HPV infection is "to treat the disease, CIN, means to treat the virus, HPV". The licensing of HPV vaccine is an important event in cancer prevention, and this vaccine can be used for the primary prevention. However, early diagnosis and early treatment are still the most basic strategies for cervical cancer prevention and treatment.
Cervical Intraepithelial Neoplasia ; diagnosis ; therapy ; virology ; Early Diagnosis ; Female ; Humans ; Papillomavirus Infections ; diagnosis ; prevention & control ; therapy ; Papillomavirus Vaccines ; Uterine Cervical Neoplasms ; diagnosis ; prevention & control ; virology

Humanities ; Knowledge ; Medicine

Anaplastic thyroid cancer (ATC) is the most aggressive thyroid tumor, with lower morbidity and higher mortality rates. Radical surgery could improve local control and survival rates. Conformal radiotherapy is superior to conventional radiotherapy, which could improve the patients’ quality of life. There are a few chemotherapeutic drugs against ATC, and the outcome of chemotherapy alone is modest. Concurrent chemoradiotherapy can prolong the survival. Targeted therapy brings new hope for refractory patients. Many cancer centers are exploring surgery, radiotherapy, chemotherapy, targeted therapy and other biological treatment of comprehensive application, in order to enhance the curative effect. This article reviewed the foregoing treatments for ATC.

Objective To investigate the protective effect of resveratrol ( RES) against hydrogen peroxide ( H2 O2 )-induced oxidative injury to astrocytes and the related mechanism. Methods Subcultured astrocytes were randomly divided into four groups:negative control group ( treated with normal culture medium) , model control group ( treated with 100 μmol·L-1 H2 O2 for 12 h), resveratrol low dose group (treated with 20 μmol·L-1 RES for 24 h H2O2 for 12 h) and resveratrol high dose group ( treated with 40 μmol·L-1 RES for 24 h before H2 O2 for 12 h) . Cell viability was detected by MTT assay, apoptosis rate was detected by flow cytometry, apoptotic cell morphology was detected by hochest33258 staining, and the expression of apoptosis-related factors such as caspses-3 and caspase-9 were measured by colorimetric detection. Results MTT assay showed that after treatment with 5, 10, 20, and 40 μmol·L-1 RES for 24 h, cell viability was (100. 46±3. 17)%, (101. 33± 3.14)%, (101. 33±1. 30)%, and (99. 67±2. 62)%, respectively, and the difference was not statistically significant as compared with the negative control group [(98. 33±2. 13)%, P>0. 05]. RES showed no effect on astrocyte activity, after treatment with 20 and 40 μmol·L-1 RES, astrocyte activity was significantly elevated to (54. 67±4. 11)% and (70.33± 2. 61)% as compared with model control group (t=3. 59, 7. 13, P<0. 05), RES inhibited hydrogen peroxide-induced decrease in cell viability. Flow cytometry results showed that after treatment with 20, 40 μmol·L-1 RES, the apoptosis rate of astrocytes significantly decreased to (35.51±3. 56)% and (14. 12%±3. 19)% (t=4. 26, 6. 33, P<0. 01) as compared with model control group (46. 31±4. 16)%. Hochest 33258 staining showed that RES inhibited hydrogen peroxide-induced cell apoptosis, besides, the RES treatment also could reduce H2 O2-induced expression of caspses-3 and caspase-9 in astrocytesin a time-dependent manner. Conclusion RES can inhibit hydrogen peroxide-induced astrocytes apoptosis through inhibiting the expression of caspses-3 and caspase-9, which can provide experimental evidence for its treatment of central nervous disorders.