1.Determination of Salivary Drug Concentration of Gentamicin and Its Clinic Significance
China Pharmacy 2001;0(07):-
OBJECTIVE:To study the correlation between salivary drug concentration and blood,drug level its clinic sig-nificance.METHODS:The salivary drug concentration and blood drug level of gentamicin of15volunteer cases were deter-mined by radioimmunoassay.RESULTS:Both blood drug level and salivary drug concentration of gentamicin reached to peak level1hour after medication.CONCLUSION:The blood drug level of gentamicin and the salivary drug concentration of gentamicin are positively correlated,i.e.it is possible for salivary to substitute for blood in the therapeutic drug monitoring of gentamicin.
2.Influence on Determination of Cyclosporine Whole Blood Samples When Prepared
China Pharmacy 1991;0(02):-
0.05),with the determination result of the whole blood-diluted sample more similar to that of the undiluated one.CONCLUSION:Whole blood sample of cyclosporine can be stored stably at room temperature at least for 2 weeks.Cold storage is the best storage method and blank whole blood was proved to be the best dilution solvent.
3.Clinical Pharmacists' Practice in Drug Treatment and Pharmaceutical Care
China Pharmacy 2001;0(08):-
OBJECTIVE:To discuss the approach for clinical pharmacists to participate in the drug treatment.METHODS:The contents and importance for clinical pharmacist to participate in ward rounds and discuss with doctors about the optimal dosage regimen were introduced.RESULTS & CONCLUSION:A satisfactory outcome was able to be achieved through efforts of both clinical pharmacists and physicians to modify and work out a new individualized dosage regimen.Clinical pharmacists can offer direct,responsible drug-related pharmaceutical care for patients by making fully use of the related pharmaceutical knowledge they have mastered.
4.The Anesthetic Management tbr the Operation of lntracramal Aneurysm
Journal of Chongqing Medical University 2003;0(05):-
Objective:To investigate the principle of anesthetic management for intracranial aneurysm.Method:The anesthetic regimens of 34 cases of intracranial aneurysm were analyzed.Controlled lowering of blood pressure and protective measures for brain were implemented introperatively to prevent rapture of cerebral aneurysm and postoperative cerebrovascular spasm.Intraoperative ECG,MAP,HR,NIBP and SPO2 were monitored and the HR,MAP before and after induction phase were compare.Result:The effects of anesthesia and lowering of Bp were satisfactory,no death occurred intraoperative!y,and aneurysm ruptured m one case.The H-Rs of whole group during induction phase were not decreased as compared with those before induction phase,and the decrease of MAP was extremely significant as compared with that after induction phase.Conclusion:The effect on parts of brain should be considered when choosing narcotics and hypotensors.Perioperative brian protection could reduce the postoperative incidence rates of arterial spasm and cerebral infarction.
5.The anesthesia effect in patients undergoing artificial abortion treated with droperidol and pethidine hydro-chloride in combination with paracervical block
Chinese Journal of Primary Medicine and Pharmacy 2015;(8):1154-1156
Objective To analyze the anesthesia effect of droperidol and pethidine hydrochloride in combina-tion with paracervical block in artificial abortion.Methods 386 patients undergoing artificial abortion were admitted. They were randomly divided into the two groups.The study group(193 cases)was treated with droperidol and pethi-dine hydrochloride in combination with paracervical block,while the control group (193 cases)was treated with droperidol and pethidine hydrochloride only.The analgesic effect,hemodynamics,cervix relaxation and side effects between the two groups were compared.Results The analgesic effect of the study group was 9 1 .7%,which was much higher than 72.0% of the control group(χ2 =25.198,P<0.01),and there were significant differences between the two groups in hemodynamics(t=4.545,3.674,all P<0.01).The total cervix relaxation were 102 cases,and partly cervix relaxation were 69 cases in the study group,which were significantly higher than that of the control group (69 cases,60 cases,respectively;Z=4.643,P<0.01).There was no difference between side effects except for abor-tion syndrome(χ2 =7.580,P=0.006).Conclusion Droperidol and pethidine hydrochloride in combination with paracervical block have an excellent effect on artificial abortion.
6.Darwin-35 and Fen-pass in the treatment of abortion after the application of the value of observation
Chinese Journal of Biochemical Pharmaceutics 2017;37(9):150-152
Objective To investigate the Diane -35, femonston of missed abortion endometrial repair. Methods According to the different treatment methods will be January 2015 to March 2017 in the first affiliated hospital of Tianjin university of traditional Chinese medicine 60 cases of patients with missed abortion groups: control group with -35 treatment, the observation group with femonston treatment; detailed observation of the two groups patients with various treatment index (bleeding time, bleeding volume, postoperative day 21 endometrial thickness, the tide time, the tide period), the occurrence of adverse reactions, and the related data were analyzed. Results Femonston (observation group) in treatment of patients with missed abortion is better than - 35 (control group) treatment, patients with various treatment index than the control group, the incidence rate of adverse reaction was lower than the control group, the difference was statistically significant (P<0.05). Conclusion Femonston can effectively repair the endometrium of patients with missed abortion, and shorten the time with the tide, the tide of stable period it is worthy of widely used intervention in patients with missed abortion.
7.Protective effects of Panaxsaponin Rb_1 on hydrogen peroxide-induced injury in human umbilical vein endothelial cells in vitro
Chinese Journal of Tissue Engineering Research 2007;0(02):-
95%,high performance liquid chromatography;provided by Chemistry College,Jilin University). The experiment was repeated for 6 times. ②Cells activity was determined by methyl thiazolyl tetrazolium(MTT),malondialdehyde(MDA) by thiobarbituric acid methods,the activity of superoxide dismutase(SOD) by xanthine oxidase methods and the expression of vascular endothelial growth factor by enzyme linked immunosorbent assay. RESULTS:①Panaxsaponin Rb1 at different dosages could improve the cell activity compared with injury control(P
8.The Training Mode and Appraisal Mechanism of Clinical Community Skills in General Practice
Chinese Journal of Medical Education Research 2006;0(07):-
Clinical communication skills are the one of seven lowest requirements of global medical education.This review emphasizes the importance of cultivating communication skills in general medical,indicates the defections of curriculum installation and discusses the training mode and examination mechanism.
9.Advance in current management of patients with anaplastic thyroid carcinoma
China Oncology 2014;(4):310-315
Anaplastic thyroid cancer (ATC) is the most aggressive thyroid tumor, with lower morbidity and higher mortality rates. Radical surgery could improve local control and survival rates. Conformal radiotherapy is superior to conventional radiotherapy, which could improve the patients’ quality of life. There are a few chemotherapeutic drugs against ATC, and the outcome of chemotherapy alone is modest. Concurrent chemoradiotherapy can prolong the survival. Targeted therapy brings new hope for refractory patients. Many cancer centers are exploring surgery, radiotherapy, chemotherapy, targeted therapy and other biological treatment of comprehensive application, in order to enhance the curative effect. This article reviewed the foregoing treatments for ATC.
10.Protective Effect of Resveratrol on Oxidative Injury in Astrocytes
Herald of Medicine 2015;(8):1002-1006
Objective To investigate the protective effect of resveratrol ( RES) against hydrogen peroxide ( H2 O2 )-induced oxidative injury to astrocytes and the related mechanism. Methods Subcultured astrocytes were randomly divided into four groups:negative control group ( treated with normal culture medium) , model control group ( treated with 100 μmol·L-1 H2 O2 for 12 h), resveratrol low dose group (treated with 20 μmol·L-1 RES for 24 h H2O2 for 12 h) and resveratrol high dose group ( treated with 40 μmol·L-1 RES for 24 h before H2 O2 for 12 h) . Cell viability was detected by MTT assay, apoptosis rate was detected by flow cytometry, apoptotic cell morphology was detected by hochest33258 staining, and the expression of apoptosis-related factors such as caspses-3 and caspase-9 were measured by colorimetric detection. Results MTT assay showed that after treatment with 5, 10, 20, and 40 μmol·L-1 RES for 24 h, cell viability was (100. 46±3. 17)%, (101. 33± 3.14)%, (101. 33±1. 30)%, and (99. 67±2. 62)%, respectively, and the difference was not statistically significant as compared with the negative control group [(98. 33±2. 13)%, P>0. 05]. RES showed no effect on astrocyte activity, after treatment with 20 and 40 μmol·L-1 RES, astrocyte activity was significantly elevated to (54. 67±4. 11)% and (70.33± 2. 61)% as compared with model control group (t=3. 59, 7. 13, P<0. 05), RES inhibited hydrogen peroxide-induced decrease in cell viability. Flow cytometry results showed that after treatment with 20, 40 μmol·L-1 RES, the apoptosis rate of astrocytes significantly decreased to (35.51±3. 56)% and (14. 12%±3. 19)% (t=4. 26, 6. 33, P<0. 01) as compared with model control group (46. 31±4. 16)%. Hochest 33258 staining showed that RES inhibited hydrogen peroxide-induced cell apoptosis, besides, the RES treatment also could reduce H2 O2-induced expression of caspses-3 and caspase-9 in astrocytesin a time-dependent manner. Conclusion RES can inhibit hydrogen peroxide-induced astrocytes apoptosis through inhibiting the expression of caspses-3 and caspase-9, which can provide experimental evidence for its treatment of central nervous disorders.