Objective To compare effect of GLEDI and alteplase on acute ischemic stroke. Methods 120 patients were randomly recruited into a GLEDI group and a alteplase group, and treated with the corresponding medicine respectively.The changes of NIHSS and hemorheology were observed. Results NISS and hemorheology in both groups were declined.There was statistic difference (P＜0.05). The GLEDI group had a greater decline in ESR than the alteplase group, showing statistic difference (P＜0.05). Conclusion Both GLEDI and alteplase were effective in treating acute ischemic stroke. They have relatively same effects ifthey were used to a full therapeutic course.

It is important and challenging for geriatricians and general practitioners to detect early and diagnose senile dementia in outpatient setting.After providing the definition of dementia,this article will discuss prompt recognition of dementia based on symptoms and signs, the neuropsychological assessment,and the biomarkers of dementia,as well as differential diagnoses.

Triple-negative breast cancer (TNBC) in elderly patients presents distinctive clinicopathologic characteristics of large volume and histological grade Ⅲ,and it is seen most frequently in invasive ductal carcinoma,adenocarcinoma and lobular carcinoma.Elderly women with TNBC significantly benefit from adjuvant chemotherapy.But older women frequently have concurrent disease,so neoplasm staging,function of vital organs and tolerance of patient should be considered when treatment programs are selected.The prognosis of older TNBC patient is worse,but rational therapy can improve outcomes significantly.

Objective: To identify the existence of the specific NMP in the human normal colon tissues and different differentiation of colon carcinoma,and try to study the association between changes of nuclear matrix protein and biological behaviar of colorectal colon carcinoma.Methods:Two-dimensional gel electrophoresis was used in the analysis of 12 matched human colon carcinomas and adjacent normal samples.MMP-9 and CB were detected by immunohistochemical SP method.Results: Analysis of multiple gels for each sample revealed that 5 proteins were present in tumor samples,but not in the matched normal colon tissues;and 3 proteins in normal colon tissues but not in the colon carcinomas.There were different NMPs in different types of colon carcinoma.One nuclear matrix protein(called N4) appeared in 9 moderate-well differentiational colon carcinomas without lymph node metastasis and in 12 normal colon tissues,but were absent in 3 poor differentiational colon carcinomas with lymph node metastasis.The result of immunohistochemistry showed that the expression of MMP-9 and CB in poor differentiational colon carcinoma which was lack of expression of NMP N4 was strongly positive,and was stronger than that in the moderate-well differentiational colon carcinomas which expressed NMP N4.Conclusion: The data suggests that there are colon carcinoma-specific NMPs.There are different NMPs in different types of colon carcinomas,and with or without lymph node metastasis.Colon carcinoma-specific NMPs may serve as the tumor markers of colon carcinoma in future.There is a relation between changes of nuclear matrix protein and lymph node metastasis of colorectal colon carcinoma;the changes of NMPs probably play a role in MMP-9 and CB expression of colon carcinoma.

OBJECTIVE: To observe the clinical efficacy of nimodipine combined with Shengmai injection on hypertensive cerebral hemorrhage. METHODS: 24 patients with hypertensive cerebral hemorrhage hospitalized within 24 hours of symptom onset were randomly divided into control group and treatment group. Both groups were given routine treatment, including reducing intracranial pressure and blood pressure and nourishing brain cells. Treatment group were additionally given nimodipine and Shengmai injection. The intracranial hematoma, perihematomal edema and CSS score were observed and compared between two groups as well as clinical efficacy. RESULTS: After 2 weeks of therapy, the level of intracranial hematoma, perihematomal edema and CSS score of treatment group were lower than that of control group, with statistical significance (P

@@

With the development of medical radiography, cone beam computed tomography (CBCT) has been widely used in stomatology because of its numerous advantages, such as adequate spatial resolution, low radiation, undistorted three- dimensional tissue information, and good applicability for hard tissue imaging. Traditional periapical radiography is based on two-dimensional image which displays the three-dimensional object and its surrounding structures. Periapical radiography can only show the overlapping mesio-distally direction bone destruction, can't show buccolingual direction bone destruction. As a kind of three-dimensional imaging technology, CBCT can show three-dimensional structure of the organization from sagittal, coronal and axial direction, to overcome the defect of two-dimensional image such as overlap and deformation. CBCT has a unique advantage than periapical radiography in the diagnosis and treatment for periapical disease. This review will summarize the difference between CBCT and periapical radiography in the periapical disease.
Cone-Beam Computed Tomography ; Humans ; Imaging, Three-Dimensional ; Periapical Diseases ; diagnostic imaging ; Radiography, Bitewing

Objective:To investigate and analyze the cognition onthe third-party mediation among medical staff in a tertiary general hospital of Nanjing,and thus to put forward rational suggestions.Method:A questionnaire survey was conducted among 200 doctors from a tertiary general hospital.Chi-square test and non-parametric test were used to analyze the data.Results:Totally 57.5％ of doctors thought the doctor-patient relationship was tense,78.5％ of doctors to some extent had understood the third-party mediation,91.5％ of doctors thoughtthe third-party mediation played a different role in dealing the medical disputes,71.0％ of doctors had heard of medical liability insurance,and 89.5％ of doctors thought it necessary to purchase the medical liability insurance.Conclusions:Doctors gradually accept the third-party mediation,but as a new thing,the main bodies at all levels should publicize the third-party mediation so as to give full play to the role of it.

In 2014, The Cancer Genome Atlas firstly classified gastric cancer into four types according to genotype. Epstein-Barr virus (EBV) positive gastric cancer or EBV-associated gastric cancer (EBVaGC) is attracting attention because it is a possibly suitable group for immunotherapy. Among the mutations observed in tumors, such as gastric cancer, p53 mutations are the most frequent. In particular, it occurs more frequently in EBVaGC than in EBV-negative gastric cancer (EBVnGC). Meanwhile, EBV infection is considered as an early event of tumorigenesis. The interactions between wild-type p53 proteins and BZLF1 (Z) proteins are essential in maintaining the latent state of EBV infection and promoting early replication. In the latter stages of replication, wild-type p53 proteins are degraded through the ubiquitination of some viral molecules. These findings may indicate the importance of wild-type p53 genes in EBVaGC formation. Inflammatory responses induced by EBV infection, tumor with a large number of lymphocyte infiltration, genome high mutation, and PD-L1 amplification make it possible to become the appropriate group of immunotherapy, which also illustrate that the important role of immune microenvironment during tumor progression. In EBVnGC, extremely high levels of p53 mutation were observed because of several associated factors, and the p53 protein encoded by the mutant p53 gene lost its antitumor function after tumorigenesis. In this review, the possible mechanisms of rare p53 mutation in EBVaGC are summarized.

Objective:To retrospectively evaluate whole body ~(18)F-FDG PET/CT in depicting the primary tomors in cervical metastatic adenocarcinoma of unknown primary site.Methods:Seventeen patients were included and underwent whole body PET/CT imaging.The primary tumors and metastases were detected by visual evaluation and measurements of standardized uptake values.The PET/CT impression was verified by histopathology and(or)follow-up.Results:In 17 patienis,primary tumors of 13 patients were confirmed by pathological or clinical follow-up.Among them,8 were in the lung,1 in breast,1 in renal,2 in colon and 1 in cervix.Among the other 4 cases,3 cases were correctly diagnosed as malignant lymphoma finally by PET/CT instead of metastatic adenoearcinoma previously.The sensitivity,specificity and accuracy of PET/CT in were 92.3%,75.0% and 88.2%,identifying primary tumors respectively.After PET/CT examination,10 patients(58.8%)were detected additional metastatic lesions which were missed previously.Conclusion:Whole body ~(18)F-FDG PET/CT may be of relatively higher value in identifying the primary tumor of cervical metastatic adenocarcinoma from unknown primary site.It also may display tumor involvement extent.