When seen from the practice and development of modern medicine,we are facing challenges from various ethical problems which arise from the progress of life support technique,industry and network technique and its application in medicine,life sciences and electronic sciences.Nowadays,the legislation of medical ethics and regulations have become a heated issue drawing the attention of doctors,pharmacists,laboratorians,nurses,medical information staff,religions personnel,philosophers,medical scientists,and lawyers.This thesis tries to analyses the main ethical problems in the use of medical information so as to justify potential eligible ethical norms in clinical practice,expecting to draw the attention of relevant staff and general public and the fulfillment of ethical norms in the medical practice.

Objective To investigate the application of xingnaojing injections ( XNJI) in inpatients and further provide a reference for the rational drug use. Methods The retrospective investigation was carried out by reviewing 186 hospitalization records with XNJI from a certain hospital from January 2014 to June 2015. The usage, dosage, and indication of XNJI were analyzed. Results Unlabeled use of XNJI was found in the neurology department inpatients. 59. 7% inpatients were treated with overdosed XNJI, and 13. 4% were treated with a single drug dose of 40 mL. The inappropriate solvent selection accounted for 49. 5%. Compatibility of XNJI and western medicine injection accounted for 54. 8%. It was also found that XNJI was used together with potassium chloride in clinic (47. 8%). Conclusion There exist some irrational uses of XNJI in clinic, thus the use and management of traditional Chinese medicine injections should be standarized.

Animals ; Antioxidants ; metabolism ; Diabetes Mellitus, Experimental ; metabolism ; Melatonin ; metabolism ; Physical Conditioning, Animal ; Rats

Objective To observe the protective effect of Danggui Buxue Decoction on 60 Co-γray irradiated mice. Methods The experimental mice were randomly divided into 5 groups ( the normal control group , model group , Danggui Buxue Decoction of low , middle and high dose groups ) .The mouse except the normal control group were irradiated by 60Co-γray and established the radiation-damage model.Peripheral blood neutrophil count (NEUT), the number of bone marrow nucleated cells ( BMC ) , the activity of serum superoxide dismutase ( SOD ) and the serum levels of malondialdehyde ( MDA) were measured .Results Radiation injury in mice of NEUT , BMC and SOD were significantly decreased (P <0.01), MDA were increased (P <0.01).Danggui Buxue Decoction can increase the levels of NEUT , BMC and SOD in mice after radiation injury , decrease the content of MDA .And protective effect of high dose group was better (P <0.01).Conclusions Danggui Buxue Decoction has protective effect on radiation injury in mice .And there is a correlation between the protection effect and dose .

Objective To explore the best sampling position of bone marrow biopsy in mice.Methods Mice were sacrificed by cervical dislocation, then take the skull, sternum, tibial, femoral and iliac bone, making pathological section.Observed and photographed under light microscope. Comparison of the distribution of the essence and the hematopoietic microenvironment in different parts.Select site which can best reflect the hematopoietic function of bone marrow.Results A large number of hematopoietic cells in ilium marrow sections visible.The cells are evenly distributed. Blood and megakaryocytes were clearly visible.The arrangement of the structure of the scaffolds for tissue closely.The number of fat cells less.Bone marrow hematopoietic cells in the skull, sternum, tibial, femoral were not clear and not active.And there are more fat cells.Conclusions As the best sampling position of bone marrow biopsy, is ilium.

Objective: To evaluate the clinical effect of individualized enteral nutritional (EN) support in severe stroke patients.Methods: Totally 120 severe stroke patients with nutritional risk were divided into two groups according to single or double admission number.The 60 patients in the intervention group received an individualized EN with different formula and concentrations according to the clinical status,and supplemented trace elements as occasion required.In the routine group, the patients received EN with standard formula.The energy supply was 83-125 kJ· kg-1·d-1 in both groups.Blood albumin(Alb), pre-albumin(PA), hemoglobin(Hb) and vitamin C(VC) were examined before and after the 21-day nutritional support.The lung infection and gastrointestinal (GI) complications were observed, and the hospital stay and cost were recorded as well.Results: After 21 day''s nutrition support, the serum levels of Alb, PA and VC in the intervention group were not statisticly significant than before (P＞0.05), and the serum levels of Alb, PA and VC were significantly higher than those in the routine group(P＜0.05).The incidence of complications in the in the intervention group was lower than that in the routine group (P＜0.05), and the length of hospital stay and hospitalization was shorter than that in the routine group (P＜0.05).Conclusion: Individualized enteral nutritional support can significantly improve nutritional status, reduce inflammation reactions and GI complications in severe stroke patients, which is worthy of clinical use.

The detection and classification of extracellular action potentials(i.e.spike) of various single neurons from extracellular recordings are crucial for extracting neuronal spike sequences and thereby for investigating the mechanisms of neural information processing in the central nervous system.In order to increase the correctness of spike detecting and sorting,a new analysis algorithm for processing multi-channel spike signals recorded from rat hippocampi with silicon microelectrode arrays is presented.Four recording contacts on the electrode array are arranged close enough to simultaneously record spikes emitted from same neurons.Firstly,the algorithm extracts all spikes in the four channel recordings by using a multi-channel threshold detection method.Secondly,the algorithm classifies the spikes based on a principle component analysis for a specifically designed type of compound spike waveforms.The compound spike waveform is formed by linking four spike waveforms of a same neuronal firing in the four recording channels one by one in series.The test results with both synthetic datasets and experimental recordings reveal that compared with corresponding traditional single-channel algorithm,the multi-channel algorithm can significantly enhance both the number of extracted spikes and the correctness of spike classifications.The algorithm can also increase the number of isolated neurons from a single experimental preparation.These results indicate that the novel method is efficient for the automatic detection and classification of neuronal spikes.

Objective To develop a new type of medical ultrasound debridement instrument and the amplitude bar. Methods According to the specific requirements of the debridement instrument, the electronic design techniques were adopted to determine the sound intensity threshold, oscillation amplitude and near-filed distance. Results The amplitude bar could meet all kinds of technical requirements, and the titanium alloy raw materials made it corrosion-resistant and anti-fatigue. Conclusion The amplitude bar adapts well to the debridement instrument, and other medal materials also can be adopted according to different requirements.

The many difficult problems in the course of actual operation are introduced in more than 5 years with governmental centralized procurement of medical equipment. By aiming at specificity of medical equipment that is a relative specialized material and applying existing laws and regulations system, the more scientific and operational solutions are found.

OBJECTIVE: The aim of this study was to investigate the association of JAK1 polymorphisms with allergic rhinitis in China Han population. METHOD: A total of 450 patients with AR and 615 healthy subjects as control were genotyped for the presence of three single nucleotide polymorphisms using polymerase chain reaction restriction fragment length polymorphism (PGR-RFLP) analysis of DNA extracted from blood samples. RESULT: All control subjects were in Hardy-Weinberg equilibrium, but high frequencies of JAK1 the homozygous rs310241 CC genotype were observed in AR patients compared to controls (P < 0.05). The results also revealed that there was no association between the rest of two investigated SNPs and AR. CONCLUSION Our results suggested that JAK1 gene rs310241 CC genotype was associated with patients with AR.
Asian Continental Ancestry Group ; genetics ; China ; Genetic Predisposition to Disease ; Genotype ; Humans ; Janus Kinase 1 ; genetics ; Polymerase Chain Reaction ; Polymorphism, Restriction Fragment Length ; Polymorphism, Single Nucleotide ; Rhinitis, Allergic ; genetics