Objective To investigate the effect of combined spinal epidural anesthesia with sitting position in parturient woman undergoing elective cesarean section. Methods One hundred parturient women undergoing elective cesarean section were divided into two groups by random digits table, 50 cases of control group adopted combined spinal epidural anesthesia with left lateral position, 50 cases of observation group adopted combined spinal epidural anesthesia with sitting position, the onset time of anesthesia, operation time, dose of ephedrine, neonatal Apgar scores and side effects of two groups were compared and analyzed. Results Three cases of control group failed to be followed up,1 case of observation group performed urgent cesarean section.The onset time of anesthesia and dose of ephedrine of observation group was significantly shorter than that of control group, there was significant difference between two groups (P < 0.05 ); the operation time and neonatal Apgar scores of two groups were compared, there were no significant differences (P > 0.05); the incidence of side effect of observation group was significantly lower than that of controlgroup [ 14.3%(7/49) vs. 31.9%( 15/47)], there was significant difference (P< 0.05). Conclusion Combined spinal epidural anesthesia with sitting position in parturient women undergoing elective cesarean section has satisfactory results, shorter onset time of anesthesia, less dose of ephedrine, lower incidence of side effect, reducing the risk of maternal and neonatal anesthesia.