Objective To investigate the clinical efficacy of carotid endarterectomy in treatment of patients with suba-cute cerebral infarction. Methods Sixty patients diagnosed and treated in our hospital were analyzed and randomly di-vided into two groups. The control group was given conservative treatment and the experimental group was given carotid endarterectomy treatment. The treatment effects of the two groups were compared. Results The treatment effects were ideal for 93.3% of the experimental group, which was higher than that of the control group (80.0%) (P<0.05); After the treatment, two groups were not significantly different in indicators such as PT, TT and FIB (P>0.05); After treatment, APTT of the experimental group was (27.9±2.4) seconds, which was lower than that of the control group(30.4±6.8) sec-onds(P<0.05); The incidence of surgical adverse reactions of the experimental group was 20.0%, which was lower than that of the control group (53.3%)(P<0.05). Conclusion The incidence of subacute cerebral infarction is relatively high. The clinical application of carotid endarterectomy shows good treatment effects, can improve clinical treatment effects and reduce the incidence of complications, thereby worthy of promotion and application.