Objective To observe the effects of stone needle on chronic obstructive pulmonary disease in acute exacerbation period (AECOPD). Methods One hundred and forty five cases of AECOPD were randomly divided into three groups. Patients in combined treatment group (n =49) received that stone needle hot compresses the back and Chinese herbal medicine besides routine treatment. Patients in Chinese herbal medicine group (n =48) received Chinese herbal medicine besides routine treatment. Patients in placebo group (n =48) received routine treatment. Results The effective rate of combined treatment group was 89.80%,and that of Chinese herbal medicine group was 85.42%,which were all significantly higher than which in placebo group (72.92%,P

This study was aimed to explore traditional Chinese medicine (TCM) compatibility patterns or rules in the treatment of ankylosing spondylitis (AS) in the real world clinical situations.The effect of TCM treatment and immune inflammatory biomarkers were analyzed by association rules,which provided evidences for AS syndrome differentiation and treatment.Retrospective study was conducted on records of hospitalized AS patients at the Department of Rheumatism,the First Affiliated Hospital of Anhui University of Chinese Medicine from June 2012 to June 2016.The technology for complex networks was integrated to analyze the core prescription.The frequency and association rules of prescription patterns were analyzed using the SPSS 21.0 and SPSS modeler 14.2.The effect on immune inflammatory biomarkers was analyzed by association rules and random walk model.The results showed that,(1) warm,cold,and neutral herbs,sweet,bitter or pungent herbs,and with the channel tropism of spleen channel,stomach channel and liver channel are the most frequently prescribed herbs;(2) herbs with functions of tonifying and replenishing,blood-activating and stasis-resolving,qi-regulating,spleen-strengthening and dampness-resolving,wind-dampness dispelling,heatclearing are frequently prescribed,which are also interrelated and interacted on each other;(3) the top five pairs of couplet herbs with the highest confidence included Hong Hua paired with Tao Ren (98.15％),Yi Yi Ren paired with Fu Ling (95.47％),Gan Cao paired Gou Ji (94.57％),Gan Cao paired with Wei Ling Xian (94.48％),Pu Gong Ying paired Bai Hua She She Cao (94.40％);(4) Shan Yao was highly related to decreased C3,C4 and hs-CRP when compatibility with Fu Ling,Niu Xi,Ze Xie;Gou Ji was highly related to decreased IgA,IgG and IgM when compatibility with Bai Hua She She Cao,Chuan Xiong,Shah Yao.Xi Qian Cao was associated with Niu Xi when ESR and WBC decreased.Gou Ji and Du Huo were associated when SOD increased.(5) The group of internal medicine coordinated with external medicine has positive growth rate of walk and improvement index of inflammatory indexes (ESR,hs-CRP) compared to single internal medicine group.It was concluded that AS treatment in the Department of Rheumatism of our hospital was based on spleen.The treatment was focused on the regulation of cold and warm,sweet and bitter,liver and spleen.The treatment of AS is to eliminate evil factors and to reinforce healthy qi.TCM has advantages in the improvement of immune inflammatory indexes.The improvement of inflammatory indexes by the internal medicine coordinated with external medicine was better than the single use of internal medicine,which is worthy of further promotion.

Traditional Chinese medicine (TCM) is widely used in gouty arthritis treatment.Based on the real world,this article studied the implicit TCM prescription pattern in order to explore TCM prescription rule in acute gouty arthritis treatment.Based on herbs recorded in the Pharmacopoeia of the People's Republic of China,TCM prescriptions of 732 hospitalized acute gouty arthritis patients at the Department of Rheumatism and Immunology,the First Affiliated Hospital of Anhui University of Chinese Medicine from June 2012 to October 2016 were collected with software system.The frequency and association rules of prescription patterns were analyzed using the SPSS Modeler 14.2 Data Mining System.Cluster analysis was conducted using SPSS 22.0 statistical software.An initial statistical analysis was carried out to categorize herbs according to their medicinal types and dosage,natures,flavors,channel tropism and functions.Based on categorization,frequencies of occurrence were computed.The results showed that,(1) warm,cold or neutral herbs,sweet or bitter herbs,and with the channel tropism of spleen channel and stomach channel are the most frequently prescribed herbs (among 732 selected medicinal formulae);(2) spleen-strengthening and dampness-eliminating,wind-dispelling and damp-removing,blood-activating and stasis-resolving,heat-clearing,deficiency-tonifying,qi-regulating herbs are frequently used;(3) correlation analysis of TCM efficacy show that three couplet medicines with the highest confidence was spleen-strengthening and dampness-eliminating herbs and heat-clearing herbs (99.24％),blood-activating and stasis-resolving herbs and wind-dispelling and damp-removing herbs (99.01％),spleen-strengthening and dampnesseliminating herbs and qi-regulating herbs (98.92％).Correlation analysis of two TCM herbs showed that three couplet medicines with the highest confidence was Hong Hua paired with Tao Ren (99.7％),Yi Yi Ren paired with Shan Ci Gu (93.04％),and Yi Yi Ren paired with Chui Pen Cao (92.67％);(4) cluster analysis classified into five types,which were based on spleen-strengthening and dampness-eliminating and in combination with blood-activating and stasis-resolving herbs,heat-clearing and detoxification,wind-dispelling and damp-removing,representing prescription compatibility characteristics.It was concluded that gouty arthritis had a close relationship with the spleen.These prescriptions focus on herbs with spleen-strengthening and dampness-resolving which seems to be the key element in the treatment process.Meanwhile,the use of spleen-strengthening and dampness-eliminating herbs,blood-activating and stasis-resolving herbs,heat-clearing herbs,wind-dispelling and damp-removing herbs is the basis of prescription patterns.

Traditional Chinese medicine (TCM) is widely used as a complementary approach for osteoarthritis treatment.This article is based on the real world.The implicit prescription patterns behind TCM formulae were examined by association rules mining and cluster analysis,so as to explore the Chinese medicinal compatibility patterns or rules in osteoarthritis treatment.This study was based on real-world data from the hospital information system (HIS).Chinese medicinal prescriptions of hospitalized patients with osteoarthritis from June 2012 to June 2016 were collected from the Department of Rheumatism and Immunology,the First Affiliated Hospital of Anhui University of Chinese Medicine.TCM was listed according to the selected medicinal formulae and the added information was organized to establish a database.The frequency and association rules of prescription patterns were analyzed using the SPSS Modeler 14.2 Data Mining System.Cluster analysis of prescription patterns was also analyzed.An initial statistical analysis was carried out to categorize herbs according to their natures,flavors,channel tropisms and functions.Based on categorization,frequencies of occurrence were computed.At the same time,the relationship between TCM and immune and inflammatory markers was analyzed.The results showed that the main prescriptive features from the selected formulae of the mining data were that,(1) warm or cold herbs,sweet or bitter herbs,and with the channel tropism of spleen channel are the most frequently prescribed herbs in 3609 medicinal formulae;(2) herbs with blood-activating and stasis-resolving,restoring vital energy,water-eliminating and damp-removing,heat-clearing and or expelling wind-damp functions are frequently prescribed;(3) association rule analysis extracted three frequently used pairs of herbs,which are Hong Hua & Tao Ren (98.90％),Pu Gong Ying & Bai Hua She She Cao (97.88％),Fu Ling & Ze Xie (92.63％);(4) association rule between TCM and immune-inflammation index showed that the pair of Du Huo and Chen Pi was associated with increased superoxide dismutase (SOD) enzyme.The pair of Mai Ya and Dan Shen was associated with decreased high-sensitivity C-reactive protein (hs-CRP),erythrocyte sedimentation rate (ESR),complement component 3 (C3),complement component 4 (C4),immunoglobulin A (IgA) and immunoglobulin G (IgG).The pair of Mai Ya and Fu Ling was associated with decreased immunoglobulin M (IgM).It was concluded that osteoarthritis was closely related to spleen deficiency.These prescriptions focus on herbs for qi-nourishing and spleen-invigorating,blood-activating and stasis-resolving,spleen-invigorating and dampness-eliminating,heat-clearing and detoxicating which seems to be the key element in the treatment process.Meanwhile,the use of restoring vital energy herbs and spleen-strengthening herbs also forms the basis of prescription patterns.

Objective:Based on the hospital information system (hospital information system,HIS) were studied in rheumatology clinical medicine data hidden behind the prescription pattern,aims to explore the treatment of rheumatoid arthritis with patterns or rules from the spleen.Methods:This study from May 2012 to December 2016 in the treatment of active rheumatoid arthritis patients as the research object in the division of Rheumatology at the First Affiliated Hospital of Anhui TCM university.The use of Office 2010,the complex network technology and IBM Clementine 14.2 SPSS Apriori software module for Chinese medicine core prescription analysis,frequency statistics,association rule analysis.Results:a total of 4 000 copies of medical records and 3 643 prescriptions of traditional Chinese medicine were included in the study,the main results are as follows:(1) the clinical medication can be divided into jianpihuashi drugs,Huoxue Huayu drugs,dispelling dampness and heat drugs in four categories,more than 60％ times the frequency of tuckahoe,liquorice,tangerine peel,coix seed,Salvia miltiorrhiza the kernel,safflower,Chinese yam,clematis root,peach kernel,core prescription:tuckahoe,liquorice,tangerine peel,Salvia miltiorrhiza,coix seed,safflower,Chinese yam,clematis root,peach kernel,dandelion;(2) drug association analysis:Poria and Oldenlandia,dandelion,Herba Siegesbeckiae,peach kernel,Chinese medicine jianpihuashi the compatibility of blood stasis,dispelling dampness and heat drugs for 20 drug combinations;(3) compare the index difference between the two groups before and after treatment,the experimental group Hs-CRP,RF,ESR,IgA,IgG and C3 compared with the control group decreased significantly after treatment,the difference was statistically significant (P＜0.05 or P＜0.01);(4) the analysis of drug and two indicators of Relevance:Jiang Banxia,Herba Siegesbeckiae and Hs-CRP,ESR decreased the incidence is higher,white atractylodes rhizome,Salvia miltiorrhiza and RF reduce the high degree of relevance,yam,dandelion and C3 to reduce the high degree of relevance,Du Zhonghe,IGA,IGG and Honghua Weilingxian to reduce the high correlation.Analysis of the three Association:Jiang Banxia,Herba Siegesbeckiae respectively with Hs-CRP,ESR,dandelion,walnuts and reduce the high degree of relevance,astragalus,salvia,licorice and RF reduce the high degree of relevance,yam,dandelion,Herba Siegesbeckiae and C3 reduce the high degree of relevance,malt,dandelion,Radix Clematidis and IGA to reduce the high degree of relevance,eucommia,safflower,licorice and IGG reduce high correlation.Conclusion:This study on the treatment of rheumatoid arthritis from the real world to the spleen,spleen wet medicine as the core,and the compatibility between blood stasis,antipyretic,rheumatism medicine prescription is the key,which can effectively improve the patients' immune inflammation and other laboratory indexes.