1.Exploring the Effects and Mechanisms of Liver Failing to Control Dispersion Caused by Long-Term Negative Emotion Accumulation on Working Memory in Normal People Based on ERPs Technique
Linpei XU ; Lile ZHOU ; Yong LIU ; Junlin HOU ; Ziwei ZHAO ; Jinchai DENG ; Zhongpeng QIN ; Anqi GAO ; Gege WANG ; Xianghong ZHAN
World Science and Technology-Modernization of Traditional Chinese Medicine 2023;25(8):2668-2676
Objective Using event-related potentials(ERPs),to study the effect and mechanism of negative emotion accumulation hepatic insufficiency on working memory in normal people.Methods Fifty subjects in each of the emotionally stable group and emotionally unstable group were given two load tasks(0-back and 1-back)in the N-back paradigm,the reaction time and correct rate were recorded,and the ERPs components N200 and P300 were detected.The latency and amplitude of P300 were analyzed statistically.Results ①Compared with the emotionally stable group,the emotionally unstable group had a longer reaction time(P<0.05).②Compared with the emotionally stable group,the subjects in the emotionally unstable group had prolonged N200 latency,decreased P300 amplitude significantly(P<0.05),and P300 latency had a tendency to extend(P<0.1).Conclusion Long-term accumulation of negative emotions and liver failure in normal people have the performance of decreased working memory,which may be related to the reduction of attention resource allocation and the impairment of cognitive processing function.
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