Objective To explore the effect of the model of comprehensive nursing interventions based on time nursing in improving therapeutic effects and prognosis of patients with schizophrenia. Methods A total of 84 cases of patients with schizophrenia were selected and were divide into two groupsby the random number table—an experimental group and a control group , both of which were 42 cases. The model of comprehensive nursing interventions based on time nursing was adopted in the experimental group and routine nursing was given to the control group until their discharge. Before and after the interventions, the Brief Psychiatric Rating Scale(BPRS) was used to evaluate the severity of the disease. The Activities of Daily Living(ADL) and the Social Disability Screening Schedule(SDSS) were used to evaluate the patients′ abilities of daily living and social skills. After the interventions, a satisfaction survey was conducted. Hospitalization time and disease recurrence of the two groups were observed. Results After the interventions,BPRS scales, ADL scales and SDSS scales were (31.50±4.23), (89.37 ± 8.16)、(6.65 ± 2.02) points in experimental group, and (45.43 ± 5.62), (81.03 ± 5.92), (8.96 ± 2.26) points in control group, the differences are statistically significant (t =2.361, 2.047, 2.206,P<0.05).The rates of satisfaction of the two groups was 95.24%(40/42) and 80.95%(34/42), and there was significant difference(χ2=6.892,P<0.05). Hospitalization time was respectively (42.86 ± 6.21)d and (67.49 ± 7.65)d in experimental group and control group, and and there was significant difference(t=2.253,P<0.05). Disease recurrence was respectively4.76%(2/42) and 23.81%(10/42),and there was significant difference(χ2=7.437, P=0.024). Conclusions The model of time nursing, with higher satisfaction level, shorter hospitalization time, and lower recurrence rate, can significantly improve the symptoms of patients with schizophrenia and enhance their self-care and social life abilities. It is worth popularizing in clinical nursing.