Intracerebral hemorrhage (ICH) is one of the most devastating diseases in neurosurgery with high mortality and morbidity. Brain edema, neuroinflammation and other related secondary injuries induced by red blood cell lysates such as hemoglobin, bilirubin and peroxidase after intracerebral hemorrhage may be key targets for poor prognosis and treatment; therefore, this article reviews the latest recent advance in the above contents as follows, in order to provide new ideas for the mechanism research and clinical diagnosis and treatment of patients with ICH.

Intracerebral hemorrhage (ICH) is one of the most devastating diseases in neurosurgery with high mortality and morbidity. Brain edema, neuroinflammation and other related secondary injuries induced by red blood cell lysates such as hemoglobin, bilirubin and peroxidase after intracerebral hemorrhage may be key targets for poor prognosis and treatment; therefore, this article reviews the latest recent advance in the above contents as follows, in order to provide new ideas for the mechanism research and clinical diagnosis and treatment of patients with ICH.