1.DISTRIBUTION OF FIBER TYPES IN THE MUSCLES OF THE FOREARM IN CHINESE
Fuqi YING ; Mingyang LI ; Shaozhuang LIU ; Xiaokai MA ; Jin GONG
Acta Anatomica Sinica 1953;0(01):-
Samples of skeletal muscle in forearm were taken from 60 sites in each of 10 normal autopsy subjects (male 7, female 3) between 3 and 69 years of age. The distribution and composition of type I and type II fibers in the muscles of the forearm were studied by histochemical method for myofibrillar ATPase. The results showed that the mean percentage of type I fibers ranged between 45% to 59% in the muscles of the forearm. In general, the slow contracting fibers of the forearm muscles were slightly higer than 50%. In the flexors and extensors of the forearm the respective percentage of type I fibers were 49.8% and 55.3%. The slow contraction fibers of the extensors muscle group showed higher proportion of type I fibers than those of the flexor group and the difference is statistically significant (P
2.The isolation of Corynebacterium tuberculostearicum from prostatic fluid
Qian YUE ; Zhenwen QIAN ; Yuanyuan YANG ; Shumei ZHAO ; Ying HUANG ; Guangxiang JIN ; Ying GONG ; Naixin ZHAO
Chinese Journal of Microbiology and Immunology 2009;29(4):294-296
Objective To carry out a taxonomic identification of a strain of claviform bacteria iso-lated from prostatic fluid of a patient who suffered from chronic prostatitis, and to approach its phylogenic and biologic position. Methods We undertaked an initial identification by phenotypic characters such as morphologecal, physiological and biochemical characteristics to ascertain its phylogeny by chemical composi-tion analysis of cell wall and 16S rRNA gene sequencing and alignment. Results A club-shaped gram posi-tive rod bacillus was isolated in pure culture state. Its biochemical reactions were not active. The diamino-acid of cell wall was meso-diaminopimelic acid (meso-DAP) and it had wall chemotype Ⅳ ( contained arabi-nose, galactose and maltose ). Sequence searches of the GenBank database revealed that this strain had a highest level of 16S rDNA sequence similarity (99.4%) to C. tuberculostearicurn strain ATCC35692 with only 8 nucleotides difference. Conclusion On the basis of phenotypic and phylngenetie analysis, it is rea-sonable to assign this strain to the species C. tuberculostearicum, and this is the first isolation of C. tubercu-lostearicum from prostatic fluid home and abroad.
3.Effects of Qingrehuayuziyin Fang on lymphocyte apoptosis and expression of Fas and FasL in peripheral blood in the patients with systemic lupus erythematosus
Wei LIANG ; Lin JIN ; Ling GONG ; Liling ZHANG ; Hui LIAO ; Ying CAI
Chinese Journal of Clinical Pharmacology and Therapeutics 2004;0(09):-
AIM: To investigate the effect of Qingrehuayuziyin Fang on lymphocyte apoptosis and expression of Fas and FasL in peripheral blood in the patients with systemic lupus erythematosus(SLE).METHODS: Eighty patients with SLE were selected and divided randomly into two groups,40 in the therapy group and 40 in control group respectively.Patients were get the treatment of Qingrehuayuziyin Fang combined hormone(prednisone) as therapy group and get hormone treating only as control group.After treating three months,lymphocyte were collected to be detected the rate of apoptosis by flow cytometer.Meanwhile,the expression of Fas and FasL were analyzed by RT-PCR.RESULTS: After three months treating,the rate of lymphocyte apoptosis was decreased significantly in therapy group compared with that in control group(P
4.Analysis of full endoscopic transnasal-transphenoidal approach for pituitary adenomas : the summary of 72 patients
Ying GUO ; Wensheng LI ; Meiqing CAI ; Hui WANG ; Haiyong HE ; Jin GONG ; Baoyu ZHANG ; Zhenchao HUANG ; Lun LUO
Chinese Journal of Microsurgery 2012;35(5):364-366,443
Objective To investigate and evaluate the clinical value of full endoscopic transnasal transphenoidal approach for the surgery of pituitary adenomas.Methods Seventy-two patients,who underwent full endoscopic transnasal transphenoidal approach for the surgery of pituitary adenomas,were selected from the Medical Center of Pituitary Adenomas of our hospital from January 2009 to March 2012.To retrospectively investigate pre- and post-operation symptoms,hormone levels,images information,operation information,complications,following-up information and so on.Results Among the 72 consecutive patients,there were 22 nonfunctioning adenomas,twenty-four prolactin secreting adenomas,seven somatotropin secreting adenomas,five adrenocorticotropic hormone secreting adenomas,one thyrotropin secreting adenomas,and 13 multi-secreting adenomas.The tumor removal was total in 56(77.8%),subtotal 13(18.0%),and partial 3(4.2%).Five cases had CSF leaks,and 6 diabetes insipidus.After 3-24 months of follow-up,the levels of increasing-hormone declined to normal levels in most patients.Conclusion Full endoscopic transnasal transphenoidal approach for the surgery of pituitary adenomas is a kind of technique which is safe,minimally invasive,having less complications and fast recovery.However,it is necessary for surgeons to accept systematic and specialized training,and own advanced equipments.
5.Neuronavigation surgery in China: reality and prospects.
Jin-song WU ; Jun-feng LU ; Xiu GONG ; Ying MAO ; Liang-fu ZHOU
Chinese Medical Journal 2012;125(24):4497-4503
OBJECTIVETo review the history, development, and reality of neuronavigation surgery in China and to discuss the future of neuronavigation surgery.
DATA SOURCESPubMed, the China Knowledge Resource Integrated Database, and the VIP Database for Chinese Technical Periodicals were searched for papers published from 1995 to the present with the key words "neuronavigation," functional navigation," "image-guided," and "stereotaxy." Articles were reviewed for additional citations, and some information was gathered from Web searches.
STUDY SELECTIONArticles related to neuronavigation surgery in China were selected, with special attention to application to brain tumors.
RESULTSSince the introduction of neurosurgical navigation to China in 1997, this core technique in minimally invasive neurosurgery has seen rapid development. This development has ranged from brain structural localization to functional brain mapping, from static digital models of the brain to dynamic brain-shift compensation models, and from preoperative image-guided surgery to intraoperative real-time image-guided surgery, and from application of imported equipment and technology to use of equipment and technology that possess Chinese independent intellectual property rights.
CONCLUSIONSThe development and application of neuronavigation techniques have made neurological surgeries in China more safe, precise and effective, and less invasive, and promoted the quality of Chinese neurosurgical practice to the rank of the most advance and excellence in the world.
Animals ; Brain ; pathology ; China ; Humans ; Neuronavigation ; methods ; Neurosurgical Procedures ; methods
6.Automated classification of ICD-O-3 morphology code from pathology reports using text-mining and support vector machine
PAN Jin ; GONG Wei Wei ; FEI Fang Rong ; WANG Meng ; ZHOU Xiao Yan ; HU Ru Ying ; ZHONG Jie Ming
Journal of Preventive Medicine 2021;33(3):255-258
Objective:
To evaluate the accuracy of automated classification of ICD-O-3 morphology code from pathology reports by text-mining and support vector machine ( SVM ) , in order to provide basis for automated tumor coding in Chinese.
Methods:
The tumor report cards of Zhejiang residents from 2017 to 2019 were collected from Chronic Disease Surveillance Information Management System of Zhejiang Province. According to ICD-O-3, the keywords of the pathology reports were extracted, and SVM was used for automatic classification. The classification results were compared with those of 16 professionals with more than two years of experience in tumor coding, and the accuracy rate, recall rate and F-score were calculated for effect evaluation.
Results:
Totally 83 082 cases from 2017 to 2019 were included and were categorized into 17 morphological classifications, with 52 877 ( 63.65% ) cases of adenocarcinoma, squamous carcinoma and transitional cell carcinoma. A total of 1 090 keywords were enrolled into main corpus. The total F-score, accuracy rate and recall rate are 85.69, 77.20% and 96.27%, respectively.
Conclusion
Text-mining combined with SVM can improve the efficiency of ICD-O-3 morphology coding; however, the accuracy needs to be further improved.
7.Evaluation on quality of internet-based reporting of COVID-19 in Ningxia, 2020-2021
MA Ying ; GONG Rui ; LI Tao ; LI Hai-jun ; WANG Xiu-qin ; MA Jin-yu ; ZHANG Wen-xia
China Tropical Medicine 2023;23(1):39-
Abstract: Objective To find out the existing problems and provide reference for further improving the quality of report information by analyzing the report cards of COVID-19 and the positive report cards of primary screening reported in Ningxia. Methods All COVID-19 case cards from 2020 to 2021 and initial screening positive cards were derived from the Chinese Information System for Disease Control and Prevention according to final review date. The timeliness of case reporting, timeliness of case review, completeness and accuracy of the case cards were analyzed. Results In Ningxia, the first case of COVID-19 was reported on January 20, 2020, and as of December 31, 2021, 122 confirmed cases and 4 symptomatic infected cases were reported. In 2021, the timely reporting rate of COVID-19 was 98.00%, which increased by 8.24% compared with 2020 (90.54%). Compared with 2020, the average time limit for diagnosis to reporting of COVID-19 in 2021 was shortened by 83.12%; in 2021, the timely review rate of COVID-19 was 100.00%, which increased by 13.84% compared with 2020 (87.84%). Compared with 2020, the time from reporting to final review was shortened by 98.91%. In 2021, the timely rate of positive reports in COVID-19 in Ningxia was 90.00%, among which the timely rate of reports by county (district) nucleic acid detection institutions was the highest (92.31%), followed by municipal (91.67%) and autonomous region (81.82%). Conclusions At the beginning of the epidemic in 2020, the timeliness of COVID-19 in Ningxia was poor, and through the implementation of measures such as technical training, supervision and inspection to continuously optimize the staffing of medical institutions and disease control institutions, the timeliness of reporting COVID-19 in Ningxia in 2021 was substantially improved, but there were still some weak links. In the future work, technical guidance and training should be carried out for weak links, and efforts should be made to improve the quality of reports.
8.Predictors of long-term remission induced by short-term intensive insulin treatment in type 2 diabetic patients
Bo ZHANG ; Ya-Li AN ; Qiu-Hong GONG ; Ying SHUAI ; Shi BU ; YAN-YAN ; Jin-Ping ZHANG ; Wen-ying YANG ; Xue-li LIU ; Guang-wei LI
Chinese Journal of Endocrinology and Metabolism 1985;0(02):-
Objective To investigate the predictors of long-term remission of type 2 diabetes induced by short-term intensive insulin treatment.Methods Fifty-four cases of diabetes mellitus with the duration of illness less than 5 years received an intensive insulin treatment for 2 weeks.The standard meal test and intravenous glucose tolerance test were performed at the baseline and 24 h after treatment completion respectively.Long-term remission meant that the diabetic patients should maintain the target glyeaemic control without any hypoglyeaemie agent within one year.Results The remission rate was 57.4% (31/54) overall,and even reached to 80.6% (29/36) in patients with the duration of illness less than 6 months,whereas,the remission rate was only 11.1% (2/18) in those with the duration of illness more than 12 months.In another view,the remission rate was significantly higher in the patients with fasting plasma glucose (FPG) level of less than 7 mmol/L (78.8%,26/ 33) 24 h after intensive treatment than those with FPG level of more than 7 mmol/L (23.8%,5/21,P
9.Targeted ribonuclease can inhibit HBV replication.
Jun LIU ; Ying-hui LI ; Cai-fang XUE ; Jin DING ; Wei-dong GONG ; Ya ZHAO ; Yu-xiao HUANG
Chinese Journal of Hepatology 2004;12(3):179-179
Cell Line
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DNA, Viral
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blood
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Hepatitis B e Antigens
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blood
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Hepatitis B virus
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genetics
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Humans
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Ribonucleases
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genetics
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Transfection
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Virus Replication
10.Design, synthesis and biological evaluation of novel 1,3 dioxolo 4,5-fisoindolone derivatives.
Yong-Xiang GONG ; Qi-Feng ZHU ; Jin-Qing ZHONG ; Li-Fei LIU ; Xu-Fei LI ; Xiao-He ZHENG ; Hong-Ying LUO ; Xu-Yang ZHAO
Acta Pharmaceutica Sinica 2015;50(2):191-198
A series of [1,3]dioxolo[4,5-f]isoindolone derivatives were designed, synthesized and evaluated as inhibitors of acetylcholinesterases (AChE). Furthermore, their effects on memory impairment of mice induced by scopolamine were investigated with step-through test. The results suggested that most of the target compounds exhibited potential inhibition on AChE with IC50 values at micromolar range. Compounds I1 (IC50 value of 0.086 μmol · L(-1)) and I2 (IC50 value of 0.080 μmol · L(-1)) showed the strongest AChE inhibitory activity, which are equipotent to donepezil (IC50 value of 0.094 μmol · L(-1)). Moreover, compounds I1-I4 could improve the memory impairment induced by scopolamine in mice.
Animals
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Cholinesterase Inhibitors
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chemical synthesis
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chemistry
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Dioxoles
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chemical synthesis
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chemistry
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Drug Design
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Indans
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Inhibitory Concentration 50
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Isoindoles
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chemical synthesis
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chemistry
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Memory Disorders
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drug therapy
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Mice
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Piperidines
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Scopolamine Hydrobromide