1.Pharmacokinetics of antibody-drug conjugates and their research progress in the treatment of gastrointestinal malignancies
Acta Pharmaceutica Sinica 2023;58(9):2632-2639
The morbidity and mortality of gastrointestinal malignancies are the highest in the world. For patients with poor response to conventional chemotherapy, new treatment methods are urgently needed. In recent years, under the background of precision medicine, antibody-drug conjugates (ADCs) with high tumor specificity and potent toxicity have become a hot research spot in the field of biomedicine. However, due to the complex structure and mechanism of ADCs, its pharmacokinetic research is facing great challenges which are the biggest resistance to the development of ADCs at present. In this case, it is of great significance to understand the pharmacokinetic properties of ADCs and make use of it to improve the efficacy of ADCs in the treatment of gastrointestinal malignancies. Based on the basic composition and mechanism of ADCs, this review summarizes the pharmacokinetic properties of ADCs, discusses its recent advances in the treatment of gastrointestinal malignancies, in order to provide more references for follow-up research on ADCs.
2.The use of standardized nutritional therapy in gastric cancer patients during perioperation
Jiuhong YOU ; Qi CHEN ; Feiyan CAI ; Ping TAN ; Jin WAN
Parenteral & Enteral Nutrition 2017;24(1):24-27
Objective:To investigate the effect of standardized nutritional therapy for gastric cancer during perioperation.Methods:Seventy-six patients with gastric cancer who underwent nutritional therapy were randomly divided into observation group (38 patients) and control group (38 patients),between May 2015 and May 2016.In the observation group,the nutritional therapy was made by medical workers who had received the training of Total Nutritional Therapy (TNT) and Goal Nutrition Therapy (GNT) for Cancer Patient.In the control group,the nutritional therapy was given by doctors according to their conventional experience.Nutritional conditions,gastrointestinal function recovery conditions,complications and hospital stays were compared between the two groups.Results:First,the weight,triceps skinfold thickness and arm muscle circumference of preoperative 1 day and postoperative 7 day in the observation patients were significantly higher than those in the control patients (P < 0.05).Second,the level of serum prealbumin of preoperative 1 day,postoperative 1 and 7 day in the observation patients was significantly higher than that in the control patients (P < 0.05).Third,the time of anus exhaust and defecate in observation group was significantly shorter than that in the control group (P < 0.01).Fourth,each group had one patient who suffered bleeding after operation,and 2 patients in control group had anastomotic leakage.Fifth,the time of hospital stays in the observation group was significantly shorter than that in the control group (P < 0.01).Conclusion:The standardized nutritional therapy for gastric cancer can improve the patient's nutrition status,promote the recovery of gastrointestinal function,and then decrease the time of hospital stays during perioperation.
3.Treatment of meniscal injuries of knee joints by arthroscopy
Jian-Hua JIN ; Qu-Qiao WAN ; Zhi-Hao CHEN ; Ying-Yao JI ; Ya-Ping JIN ;
Chinese Journal of Primary Medicine and Pharmacy 2006;0(12):-
Objective To assess the effectiveness of treatment of meniscal injuries of knee joints by arthroscopy.Methods 33 patients 35 joints were followed up and the parts,types and treatment under arthroscopy were analysed.Results 33 patients were followed up from six months to six years,the mean preoperative Lysholm score was 60.5 points,and the mean postoperative one was 86.7 points.Conclusion The advantage of treating meniscal injuries by arthroscopy was the result of correct examination and little wound of arthroscopy operation,and arthroscopic repair or partial menisectomy could effectively restore the function of the injured knee.
4.Epinephrine modulates the ratio of pro-inflammatory mediators and anti-inflammatory mediators in murine macrophages treated with LPS
Li ZHANG ; Duyun YE ; Ping WU ; Yanjun HUANG ; Ping YUAN ; Jingyuan WAN ; Tao WU ; Xiaoyan ZHOU ; Shengwei JIN
Chinese Journal of Pathophysiology 1986;0(03):-
AIM: To investigate the effect of epinephrine on LPS-induced pro-inflammatory mediators (TNF-?, NO and COX-2) and anti-inflammatory mediators (HO-1 and IL-10) production in murine macrophage RAW264.7 cells, and to determine whether these effect is due to the influence of epinephrine on NF-?B activation. METHODS: RAW264.7 cells were cultured in vitro with 10 ?g/L LPS in the absence or presence of epinephrine at variant concentrations (1, 5, 10, 50 ?mol/L) for 24 hours, then the supernatants was collected for measuring TNF-? and IL-10 by ELISA and Griess reagent was used to measure NO (NO_2-/NO_3-) concentration. At the same time point, cells were harvested and COX-2, HO-1 and I?B-? was detected by Western blotting. RESULTS: 10 ?g/L LPS significantly induced the production of TNF-?, NO (NO_2-/NO_3-), COX-2, HO-1 and IL-10. When epinephrine was added into the medium together with LPS, the pro-inflammatory mediators production was decreased in a dose-dependent manner, however, anti-inflammatory mediators HO-1 and IL-10 expression was enhanced by epinephrine. Epinephrine has no significant effect on I?B-? degradation in LPS-activated RAW264.7 cells. CONCLUSION: Epinephrine down-regulates LPS-induced pro-inflammatory mediator expression while promotes anti-inflammatory mediator production in murine macrophages. These effect seems to be independent of NF-?B activation.
5.Extrapleural solitary fibrous tumor: report of a case.
Jin-hong MEI ; Hong-ping WAN ; Han LIU ; Ren-sheng CHEN ; Hui-chun GAO ; Shan XU
Chinese Journal of Pathology 2006;35(8):510-511
6.Expression of survivin E-cadherin and Ki-67 in pituitary adenoma and correlation with invasiveness.
Chun-Liang WANG ; Jin-Hong MEI ; Hong-Ping WAN ; Ren-Sheng CHEN ; Lin-Lin XU
Chinese Journal of Pathology 2008;37(5):335-336
Adolescent
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Adult
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Aged
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Cadherins
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genetics
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metabolism
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physiology
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Female
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Humans
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Inhibitor of Apoptosis Proteins
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Ki-67 Antigen
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genetics
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metabolism
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Male
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Microtubule-Associated Proteins
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genetics
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metabolism
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physiology
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Middle Aged
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Neoplasm Invasiveness
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physiopathology
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Pituitary Neoplasms
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pathology
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physiopathology
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Young Adult
7.The Effects of Compound Tripterygium Hypoglaucun Hutch on Photoallergic Contact Dermatitis of Murine Model
Xiang NONG ; Li HE ; Ping WAN ; Yongli ZOU ; Ling LIU ; Jin GUO
Chinese Journal of Dermatology 2003;0(10):-
Objective To study the efficacy and mechanism of compound Tripterygium hypoglaucum Hutch (THH) on photoallergic contact dermatitis in mice. Methods The photoallergic animal model of BALB/c mice was established by using photosensitizer chlorpromazine and UVA irradiation. The therepeutic efficacy was determined by measuring the thickness and the weight of the swelling ear and the number of infiltrated mononuclear cells in the ear tissue. Immunohistochemical technique was used to detect the ICAM-1 expression on keratinocytes, fibroblasts and vascular endothelial cells. The serum level of INF-? was measured by ELISA. The tested animals were divided into 3 groups: compound THH, THH alone and normal saline. Results The difference of the thickness of left ear before and after challenge, the differences of the thickness and the weight of ear tissue, the difference of the number of infiltrated mononuclear cells of left and right ear after challenge were significantly less in the compound THH group than those in the THH alone group (P
8.Non-preventive use of antibiotics in patients with severe acute pancreatitis treated with integrated traditional Chinese and Western medicine therapy: a randomized controlled trial.
Xiaonan YANG ; Lihui DENG ; Ping XUE ; Long ZHAO ; Tao JIN ; Meihua WAN ; Qing XIA
Journal of Integrative Medicine 2009;7(4):330-3
To investigate the prognostic effects of integrated traditional Chinese and Western medicine therapy without antibiotics in treatment of patients with severe acute pancreatitis (SAP).
9.Comparison of Oral-pharyngeal Resonance Function between Spastic and Athetoid Cerebral Palsy Children
Xing JIN ; Ping WAN ; Xubo WU ; Kexing SUN ; Haimeng ZHANG ; Zhaoming HUANG
Chinese Journal of Rehabilitation Theory and Practice 2012;18(10):913-915
Objective To explore whether there is significant difference in the oral-pharyngeal resonance function between children with spastic and athetoid cerebral palsy. Methods The acoustic parameters (F1、F2) of /ɑ/、/i/、/u/ were compared between these two kinds of children. Results The incidence of oral-pharyngeal resonance disorder were 71% and 95% in the children with spastic cerebral palsy and athetoid cerebral palsy respectively. There was no significant difference in F1 and F2 of /ɑ/、/i/、/u/ between these two kinds of children. Conclusion The incidence of oral-pharyngeal resonance disorder is high in both two kinds of children, and there is no significant difference in the oral-pharyngeal resonance function between them.
10.A receptors in the NTS modulate depression of carotid baroreflex induced by intracerebroventricular injection of histamine in rats.
Guo-Qing WANG ; Jun SONG ; Wan-Ping SUN ; Jin-Hua LI ; Xi-Ping ZHOU
Chinese Journal of Applied Physiology 2007;23(1):57-61
AIMTo investigate the roles of alpha1 and alpha2 receptors in the nucleus tractus solitarius (NTS) in the carotid baroreflex (CBR) resetting induced by the intracerebroventricular injection (ICV) of histamine (HA).
METHODSThe left and right carotid sinus regions were isolated from the systemic circulation in 25 Sprague-Dawley rats anesthetized with pentobarbital sodium. The intracarotid sinus pressure (ISP) was altered in a stepwise manner. ISP-mean arterial pressure (MAP) relationship curve and its characteristic parameters were constructed by fitting to the logistic function with five parameters. The changes in CBR performance induced by ICV HA and the effects of pretreatment with alpha1 or alpha2 receptor antagonist into the NTS on the responses of CBR to HA were examined.
RESULTSICV HA (60 micromol x L(-1) in 5 microl) significantly shifted the ISP-MAP relationship curve upwards (P < 0.05) and moved the middle part of ISP-Gain relationship curve downwards (P < 0.05), and reduced the MAP range and maximum gain (P < 0.05). The pretreatment with phenoxybenzamine (PBZ, a selective antagonist of alpha1 receptor, 3 micromol x L(-1) in 500 nl) or yohimbine (YOH, a selective antagonist of alpha2 receptor, 2.5 micromol x L(-1) in 500 nl) into the NTS could obviously intensify the above-mentioned changes in CBR performance induced by HA, but the intensive effect of PBZ was less remarkable than that of YOH (P < 0.05).
CONCLUSIONThe intracerebroventricular administration of HA results in a rapid resetting of CBR and a decrease in reflex sensitivity, and the functions of alpha1 and alpha2 receptors in the NTS might weaken CBR resetting induced by ICV HA. Furthermore, alpha2 receptor in the NTS might play an more important role in modulating the responses of CHR to HA.
Animals ; Baroreflex ; drug effects ; Blood Pressure ; Carotid Sinus ; drug effects ; Histamine ; administration & dosage ; pharmacology ; Injections, Intraventricular ; Male ; Rats ; Rats, Sprague-Dawley ; Solitary Nucleus ; drug effects ; physiology