1.Stereological study of the effects of Doxycycline on hyperoxic lung injury In neonatal rats
Chinese Pediatric Emergency Medicine 2009;16(3):256-259
Objective To explore the influence and potential protective effects of non-specific panMetrix Metalloproteinases(MMPs) inhibitor Doxycycline on hyperoxic lung injury and lung development in neonatal rats.Methods Neonatal SD rats were divided into 4 groups randomly within 12 hours after birth:air with normal saline(AN),air with doxycycline(AD),hyperoxia with normal saline(ON),and hyperoxia with doxycycline group(OD).Hyperoxia groups(ON and OD) were exposed to ≥90% O2.Doxycycline 20 mg/kg or equal volume of 0.9% saline(Doxycycline concentration 2 mg/ml) was administered by gastric gavage,twice daily from day 1 to experimental day,but it didn't exceed 14 days.Stereological study was carried out at day 1,3,7,14 and 21 after birth.Results Enlarged mean alveolar area was noted both in hyperoxia and Doxycycline groups.OD group had larger star volume than ON group on day 14.Except ON group,all other groups had increased alveolar septum and the condition was worsened by hyperoxia with Doxycycline.The percentage of collagen in lung parenchymal tissue in ON group increased persistently.This increasing trend was stopped in OD group on day 14,and collagen percentage had no significantly difference between OD and AN groups on day 14 and 21.Conclusion Both hyperoxia and Doxycycline influence neonatal lung development,percentage of coUgen in lung parenchymai can be reduced by Doxycycline in hyperoxic lung injury.
2.Dynamic Analysis of Chongqing Health Resource Allocation and Utilization Since Being a Municipality
Chinese Journal of Medical Education Research 2003;0(04):-
This paper gave a dynamic analysis on the health resource allocation and utilization of Chongqing since it became a municipality,found out the extrusive problems existing in the health resource allocation and put forward some corresponding proposals,hoping to benefit the health administration on constituting regional health development planning.
3.Solitary necrotic nodule of the liver.
Zhong ZUO ; Jin-feng ZHANG ; Feng-xian TANG ; Liang FENG
Chinese Journal of Pathology 2006;35(5):317-317
Adenocarcinoma
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complications
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pathology
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surgery
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Aged
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Colectomy
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methods
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Colonic Neoplasms
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complications
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pathology
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Diagnosis, Differential
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Female
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Hepatectomy
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methods
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Humans
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Liver
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pathology
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surgery
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Liver Diseases
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complications
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pathology
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surgery
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Necrosis
4.Extranodal follicular dendritic cell sarcoma of neck region: report of a case.
Chinese Journal of Pathology 2012;41(6):410-411
Antineoplastic Combined Chemotherapy Protocols
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therapeutic use
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Carcinoma
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metabolism
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pathology
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Cyclophosphamide
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therapeutic use
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Dendritic Cell Sarcoma, Follicular
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drug therapy
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metabolism
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pathology
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surgery
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Diagnosis, Differential
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Doxorubicin
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therapeutic use
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Head and Neck Neoplasms
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drug therapy
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metabolism
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pathology
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surgery
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Humans
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Lung Neoplasms
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drug therapy
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secondary
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Male
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Melanoma
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metabolism
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pathology
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Middle Aged
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Neoplasm Recurrence, Local
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Prednisone
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therapeutic use
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Receptors, Complement 3b
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metabolism
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Receptors, Complement 3d
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metabolism
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Vincristine
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therapeutic use
5.Detection of mutations of the dystrophin gene in Duchenne muscular dystrophy boys.
Rong HUANG ; Jin-feng ZHANG ; Jun XU
Chinese Journal of Pediatrics 2009;47(1):68-69
Child
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DNA Mutational Analysis
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Dystrophin
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genetics
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Exons
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Humans
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Male
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Muscular Dystrophy, Duchenne
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genetics
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Mutation
6.Clinical study of femoral peel-off lesions in acute posterolateral corner injuries
Jin ZHANG ; Hua FENG ; Hui ZHANG ; Lei HONG ; Xuesong WANG
Chinese Journal of Orthopaedics 2011;31(5):456-462
Objective To determine the incidence of clinically common acute avulsions of the popliteus tendon (PT) and the lateral collateral ligament (LCL) of the femur (peel-off lesion) in knees with multiple injured ligaments.Methods A retrospective review of 48 acute grade 3 posterolateral corner (PLC) knee surgeries was conducted.All office evaluations were reviewed to determine the demographic data,tear description,preoperative MRI examination,physical examination under anesthesia,intraoperative arthroscopic findings and surgical techniques.Results In total,19 patients were surgically verified as having femoral peel-off lesions as a portion of a series of multiple pathologic findings.Tear patterns were typically categorized into 3 patterns:isolated PT tear (pattern 1,4 patients),combined PT and LCL tears (pattern 2,8 patients) and complex tears (associated intrasubstance and/or fibular-based injuries,pattern 3,7 patients).Seventeen of the 19 patients underwent preoperative MRI examination,which demonstrated conclusive signs of femoral insertion separation and discontinuity in 13 patients (76%) and inconclusive signs of femoral insertion separation.Examination under anesthesia (EUA) revealed that for the 4 patients with pattern 1 injuries,the tibial external rotation increases were all greater than 10°.For the 15 patients with pattern 2 and 3 injuries,the yarus instability was as follows:grade 3 in 8 patients,grade 2 in 2,grade 1 in 1,and negative in 4.External rotation increases were greater than 10° in 12 patients and less than 10° in 3.Seventeen of the 19 patients were inspected with an arthroscope prior to PLC surgery:of these patients,94% had acute avulsion findings and positive lateral gutter drive-through sign;8 patients were repaired with recess or reattachment procedures;6 patients were primarily reconstructed;4 patients were treated with combined repair and reconstruction;and 1 patient was left untreated for secondary reconstruction due to priority repair for concurrent patellar tendon rupture.Conclusion For adequate clinical identification,we recommend a comprehensive diagnostic protocol,including MRI,physical examination and arthroscopic inspection,to avoid underdiagnosis of the lesion in multiple-ligament injured knees.The lateral gutter arthroscopic evaluation is particularly sensitive for detecting the lesion.
7.Promethazine should not be used for infants.
Feng-ling XU ; Ya-ming ZHANG ; Ying-ji JIN
Chinese Journal of Pediatrics 2010;48(7):557-557
8.Rapid analysis of piperazine ferulate tablets by optic-fiber sensing technology and the similarity of ultraviolet spectra
Li LI ; Chunling ZHANG ; Lu JIN ; Cuijuan FENG
Journal of Pharmaceutical Analysis 2012;02(4):310-313
A rapid analysis method of piperazine ferulate tablets by optic-fiber sensing technology with UV-vis absorption spectrum was established.Qualitative and quantitative data were obtained and compared by maximum and minimum wavelength,absorbance and contrast spectra.Similarity method was used to identify authenticity of drugs.The difference of contents measured by this method and UV determination method in China Pharmacopoeia showed no statistical significance (P>0.05),while the similarity can be used as a parameter to identify the authenticity of drugs.
9.A Comparative Study on HIV/AIDS Knowledge, Attitude and Behavior for Undergraduates from Different Universities in Kunming
Zheng ZHANG ; Shangwen WANG ; Jun FENG ; Li JIN
Journal of Kunming Medical University 2016;37(11):130-133
Objective To investigate the HIV/AIDS knowledge,attitude and behavior among undergraduates from different universities in Kunming and to provide scientific basis for health education strategy.Methods Stratified random cluster sampling method was applied and an anonymous questionnaire was conducted in 879 first and second year students from three universities in Kunming (Kunming Medical University,Yunnan University and Yunnan Art Institute).Results Undergraduates from different universities in Kunming performed differently on cognition of HIV/AIDS knowledge.Cognitive level in Yunnan Art Institute was relatively low while no obvious difference was found in Kunming Medical University and Yunnan University.No significant difference in the attitude toward HIV/AIDS was found in the three universities.Differences were found in protective behaviors and attitudes on preventing HIV/AIDS infection among three universities.Conclusion There are different cognition on HIV/AIDS knowledge,attitude and behavior among undergraduates from different type universities in Kunming.Cognition on HIV/AIDS related knowledge is relatively weak among Art college students,who should be targeted to strengthen health education.
10.Effects of Compound Uncaria Hypotensive Tablets on Expressions of MCP-1 and MMP-9 of Vascular Remodeling in Spontaneously Hypertensive Rats
Jin FENG ; Wen ZHANG ; Jun QING ; Huimin LIU ; Yuansheng TAN
Chinese Journal of Information on Traditional Chinese Medicine 2016;23(10):51-55
Objective To observe the effects of Compound Uncaria Hypotensive Tablets on expressions of MCP-1 and MMP-9 of vascular remodeling in spontaneously hypertensive rats (SHR); To discuss it possible mechanism of action. Methods Totally 24 12-week old male SHR were randomly divided into SHR model group, Compound Uncaria Hypotensive Tablets group, and positive medicine group, with 8 rats in each group. Another 8 WKY rats were set as normal control group. Medication groups were given relevant medicine for gavage for successive 6 weeks. Noninvasive tail cuff method was used to observe blood pressure; morphological changes in thoracic aorta and renal artery were observed by HE staining; immunohistochemistry was used to detect the protein expressions of MCP-1 and MMP-9 in thoracic aortic wall. Results Protein expressions of MCP-1 and MMP-9 in thoracic aortic wall of SHR model group were significantly higher than those of normal control group (P<0.01); Compared with the SHR model group, protein expressions of MCP-1 and MMP-9 in thoracic aortic wall decreased significantly in the medication groups (P<0.05, P<0.01); Compared the Compound Uncaria Hypotensive Tablets group and positive medicine group, there was no obvious difference in protein expressions of MCP-1 and MMP-9 in thoracic aortic wall. Conclusion Compound Uncaria Hypotensive Tablets can reduce the blood pressure of SHR, reduce inflammation reaction, and regulate vascular remodeling, which mechanism may be related to down-regulation of expressions of MCP-1 and MMP-9 in SHR aortic endothelial cells.