Because of the long acquisition time and spin-echo planar imaging sequence, diffusion weight magnetic resonance image (DWI) should be denoised effectively to ensure the follow-up applications. The commonly used denoising methods which induced from gray level image lack the use of the specific information from multiple magnitude directions. This paper, therefore, proposes a modified linear minimum mean square error (LMMSE) denosing method used for DWI. The proposed method uses the local information to estimate the parameter of the Rician noise and modifies the LMMSE using the information of multiple magnitude directions synthetically. The simulation and experiment of the synthetic DWI and real human brain DWI dataset demonstrate that the proposed method can more effectively remove the Rician noise compared to the commonly used denoising method and improve the robustness and validity of the diffusion tensor magnetic resonance image (DTI).
Algorithms ; Brain ; anatomy & histology ; Computer Simulation ; Diffusion Magnetic Resonance Imaging ; Diffusion Tensor Imaging ; Humans ; Image Enhancement ; methods ; Image Interpretation, Computer-Assisted ; methods ; Least-Squares Analysis ; Reproducibility of Results

OBJECTIVE To improve the professional ability of nosocomial infection managers.METHODS By analyzing the status quo and questions among nosocomial infection managers,we explored the essentiality of professionalism construction of the team of nosocomial infection managers and brought forward a way for it.RESULTS It is necessary to set up a professional education and culture system,improve the related guarantee system and keep the team of nosocomial infection managers in stabilization for strengthening the professionalism construction of the team.CONCLUSIONS It is the objective requirement to promote the construction and development of nosocomial infection discipline that impels professionalism construction of the team of nosocomial infection managers.

OBJECTIVE To investigate the function of department of nosocomial infection management in practice.METHODS It was analyzed the situation that the functional management of department of nosocomial infection in China could not be fully used at present.As far as the main content of nosocomial infection control was concerned,it brought forward the idea of performing the functional management of department of nosocomial infection in practice.RESULTS According to establishing the function of department of nosocomial infection management,strengthening the professional ability,and improving the service,both the effect and quality of nosocomial infection management could be enhanced.CONCLUSIONS The same as medical treatment,scientific research,nursing and logistic management,nosocomial infection management should stick to the legal management,and then its function can be effectively used.

Objective: To discuss the method for establishing the relationship between chromatographic fingerprints and its usage in process control. Methods: The relationship between chromatographic fingerprints of a fermentation product Ganoderma capense and its finished preparation had been developed according to guidance on fingerprint of Chinese traditional medicinal medica. As for peaks whose acceptance criteria of relative area should be set, their relative areas in chromatographic fingerprints of raw material and its finished product, the ratios of relative areas of peaks from raw material to those from finished product and their relative standard differences were calculated. Results: The relative standard differences of the rations of all peaks whose acceptance criteria areas should be set, were less than 8%. Conclusion: The results show that the rations and RSDs are enough to represent the quantitave relationship between chromatographic fingerprints, and the acceptance criteria of RSD should be less than 10% (n≥10). The quality of finished product can only be assured if the acceptance criteria of relative areas of peaks in chromatographic fingerprint of raw material are tighter than those set according to guidance, and the manufacture process keeps consistency.

Humans ; Lymphoma, Large B-Cell, Diffuse ; Societies, Medical ; United States

Adult ; Diagnosis, Differential ; Drugs, Chinese Herbal ; therapeutic use ; Humans ; Male ; Medicine, Chinese Traditional ; Middle Aged ; Phytotherapy ; Prostatitis ; drug therapy ; prevention & control

Audiology ; China ; Congresses as Topic ; Humans ; Vestibular Diseases

Humans ; Periodontal Diseases ; therapy ; Tissue Engineering

Adult ; Benzene ; poisoning ; Cord Blood Stem Cell Transplantation ; Female ; Humans ; Infant, Newborn ; Leukemia ; etiology ; surgery ; Male ; Treatment Outcome ; Young Adult

Objective To investigate the cytotoxicity and mechanism of killing tumor of cytokine-induced killer (CIK) cells in vitro.Methods Mononuclear cells were acquired freshly from bone marrow of children with leukemia,and the cells obstained were induced into dendritic cells by adding granulocyte-macrophage colony-stimulating,IL-4,TNF-? and other cytokines.Lymphocytes cells were isolated freshly from peripheral blood of children with leukemia by Ficoll-Hypaque density centrifugation,and the cells obstained were induced by IFN-?,IL-2 and CD3McAb.The DC cells and CIK cells were co-cultured for 10-25 days,then DC-CIK cells were obtained.Phenotypes of DC-CIK were analyzed by flow cytomery.The cytotoxicity of DC-CIK against a variety of leukemic cell lines was investigated by MTT technique.When treated with mouse-anti-human LFA-1 monoclonal antibody,the expression of GATA-3 and T -bet in the levels of mRNA and protein were mea-sured by using RT-PCR and Western Blot technique,respectively.Results In the first 0-6 days,DC-CIK induced slowly,the proliferation of DC-CIK got 100-fold at the 13th day,cells were rapidly proliferating in the first 13-21 days.The maximum proliferation of DC-CIK reached at the 22nd day.The phenotypes of CD3,CD11a,CD54,HLA-DR were expressed highly; CD3/CD56,CD25,CD28,CD69,FasL were expressed moderately on DC-CIK.The expression of CD16 was not increased.DC-CIK possessed the cytotoxicity against tumor cells of B95,Jhhan and M07e.The effect was stronger to B95,there was no significant difference when the efficiency target ratio was 12.5:1.0 or 25:1,the cytotoxicity reached about 50% and 60%,respectively,against tumor cells of B95.However,it was not obvious to Jhhan and M07e.When the efficiency target ratio was 12.5:1.0 or 25:1,the cytotoxicity reached to 27.21%,25.13%,33.05%,29.72%,respectively,against tumor cells of Jhhan and M07e.When treated with mouse-anti-human LFA-1 monoclonal antibody,the expression of GATA-3 in the level of mRNA was up-regulated(t=3.425,4.523 Pa