ObjectiveTo investigate the effect of different reference vessel groups on CT perfusion in patients with nasopharyngeal carcinoma (NPC) after radiation therapy,and explore the feasibility of substitution of reference vessel.MethodsThirty patients with NPC after radiation therapy were divide into two groups,recurrence group ( n =19) and fibrosis group ( n =11 ).All patients underwent CT perfusion scans,and the CT parameters were calculated with different arterial input and vein output in order to study their differences.The vessels were internal carotid artery-internal jugular vein( ICA-IJV group),external carotid artery-retomandibular vein (ECA-RTV group)and external carotid artery-internal jugular vein( ECAIJV group) respectively.The differences of the CT parameters between local recurrence group and fibrosis group were compared among the various vessel groups by rank sum test.With the help of receiver operating characteristic curve (ROC),the diagnostic efficiencies were compared by the area under the ROC curve (AUC).ResultsIn ICA-IJV group,ECA-RTV group and ECA-IJV group,bloood flow(BF) of local recurrence group were 201.88,439.59,252.23 ml · min-1 · 100 g-1,while BF of fibrosis group were 98.96,180.50,106.55 ml · min-1 · 100 g-1.Blood volume (BV) of local recurrence group were 6.71,12.39,6.70 ml/l00 g,while BV of fibrosis group were 2.35,4.76,2.95 ml/100 g.Mean transit time (MTT) of local recurrence group were 1.66,1.50,1.56 s,while MTT of fibrosis group were 2.13,1.96,1.79 s.Permeability surface (PS) of local recurrence group were 19.31,36.39,15.22 ml · min- 1 ·100 g-1,while they were 16.58,29.08 ,16.63 ml · min-1 · 100 g-1 in the fibrosis group.The differencesof BF and BV between the local recurrence group and fibrosis group were statistically significant in each vessel group (P ＜ 0.05 ) but MTT and PS showed no significant difference( P ＞ 0.05 ).In ICA-IJV group,the AUC of BF,BV,MTT,PS were 0.909,0.947,0.677,0.703,respectively.BF,BV,MTT,PS in ECA-RTV group were 0.938,0.967,0.648,0.679 respectively,and those in ECA-IJV group were 0.861,0.890,0.641,0.656 respectively.However,AUC of BF and BV of three groups all had significant difference ( P ＜ 0.01 ).ConclusionsBoth BF and BV values calculated by three pairs of reference vessels had enough diagnosis efficiency for local recurrence and fibrosis,so all of the three groups of vessels may substitute each other in CT perfusion.

Objective To explore the correlation between executive function and white matter lesions (WML) and the diagnostic value by clock drawing test(CDT) in patients with vascular dementia (VaD). Methods Twenty-seven VaD patients and twenty-five normal control subjects were evaluated with CDT to assess the executive function. CDT was scored according the four point method. Age-related white matter change rating scale (ARWMCrs) was used qualitatively to measure and locate the WML by cranial MRI scanning. Results 1. The scores of CDT in normal cognition health and VaD were ( 3.88 ± 0. 33 ) and ( 1.74 ± 0. 98 ). The difference between two groups was statistically significant (P＜0. 01 ). The humerous part and the point part were the earliest to decline in the VaD Patients. The scores of WML were (5.12 ± 4. 19) and ( 11.19± 3.09), respectively. There was significant difference between two groups(P ＜ 0. 01 ). The scores of CDT had significant positive correlation with MMSE scores and negative correlation with WML scores (P ＜ 0. 01 ). Conclusion The executive functional impairment in patients with VaD could be associated with the degree of WML.

Objective To investigate the characteristics and extent of mononuclear ceils DNA damage in peripheral blood of mice fed with low dose T-2 toxin and Deoxynivalenol(DON) alone or in combination and to explore the long-term toxicity of the toxin at sub-clinical dose. Methods Eighty female Balb/c mice weighing (14.0 ± 1.5)g 3 weeks after birth were divided randomly into control group, T-2 toxin group, DON group and T-2 toxin combined with DON group according to their body weight, 20 in each group. The mice were injected intraperitoneally T-2 toxin(5 μg·kg-1·d-1), DON(20 μg·kg-1·d-1), T-2 toxin(5 μg·kg-1·d-1) combined with:DON (20μg·kg-1·d-1)respectively,control group were treated by isotonic NaCl. In 16 weeks and 21 weeks of exposure, the tail blood of the mice was collected. The comet rate, tail DNA content,tail length and tail extent moment of mouse mononuclear ceils in peripheral blood was observed using single cell gel electrophoresis(SCGE). Results ① In T-2 toxin group,tail DNA content,tail length and tail extent moment were (27.71 ± 15.85)%, (13.67 ± 5.56)μm, 4.26 ± 3.83 at 16 weeks and (28.38 ± 15.57)%, (13.83 ± 5.47)μm, 4.37 ± 3.82 at 21 weeks, all levels of the indexes increased. In the control group, the corresponding values were (11.87 ± 4.61)%, (10.59±6.70)μm, 1.34±0.98 at 16 weeks and (11.31 ± 3.94)%, (10.83 ± 7.05)μm, 1.29±1.01 at 21 weeks, the differences in the two groups were significant (all P < 0.05) ;②In DON group, the comet rate of cells, tail DNA content and tail extent moment of comet ceils were 5.62%, (28.13 ±13.31)%, 3.39 ± 2.35 at 16 weeks and 7.71%, (29.17 ± 15.12)%, 5.70 ± 4.17 at 21 weeks. In the control group, the tailing rate was 4.34% at 16 weeks and 4.38% at 21 weeks, the differences in the two groups were significant (all P < 0.05);③In the group of T-2 toxin combined with DON,the comet rate, tail DNA content, tail length and tail extent moment was 6.21%, (30.14 ± 15.48)%, (16.93± 6.58)μm, 5.54 ± 4.22 at 16 weeks and 8.17%, (30.85 ± 15.76)%, (17,21±6.45)μm, 5.70 ± 4.17 at 21 weeks. Moreover, the levels were significantly higher than that in the control group(all P < 0.05). The tail DNA content and length of comet cell tail significantly increased in the combine group compared with T-2 group or DON group(P < 0.05). Conclusions Low dose T-2 toxin or DON can definitely result in DNA damage of mononuclear cells in peripheral blood of mice. The damage induced by T-2 toxin combined with DON is severer than that caused by T-2 toxin or DON alone.

OBJECTIVE To use the software for hospital infection control in our hospital to improve monitoring of nosocomial infection in invasive nursing procedure and reduce incidence rate of nosocomial infections.METHODS The software for hospital infection control was used in this prospective investigation to collect common information of invasive nursing procedure,institute intervention measure to invasive nursing procedure,and observe the(occurrence) of nosocomial infection.RESULTS Element administration,process administration,and monitoring(administration) were used to real-time control in invasive nursing procedure,thus fasten information transfer and optimize(performance) flow-sheet of nosocomial infections administration.The software usage could accurately(provide) the(information) of nosocomial infection in-time,and feed-back rapidly.CONCLUSIONS Whole process(control) in invasive nursing procedure can discover and solve problems,thus improve efficiency and effectiveness for preventing and controlling nosocomial infection.

OBJECTIVE To improve the level of pathogen detection with the software for drug-resistance message input system. METHODS The software which manufactured by the First Affiliated Clinical hospital of General Hospital of PLA,can detect, analyze,calculate and inquire to samples of inpatients. RESULTS The software may classify the drug-resistance with different partner statistic means.Moreover,it can calculate the sample detection rate and positive rate. CONCLUSIONS The software may provide efficiency and effectiveness for drug-resistance detection.

ObjectiveDiabetes is an independent risk factor for coronary artery bypasss grafting(CABG). Off pump coronary artery bypasss (OPCAB) experience in 251 cases was reviewed to determine whether diabetes wou ld be applicable in OPCAB procedures.MethodsConsecutive 251 patients underwent OPCAB over 12 month period. This study included 71 diebetic patients (DM group) and 180 nondiabetic patients (NDM group). Preoperative v ariables were compared between the two groups by univariate analysis.R esultsNo differences were found regarding the length of stay in cardio intensive care unit [DM group(2.4?0.3)d; NDM group (2.4?0.3) d;P=0. 386], and sternal complication (DM group: 5.7%;NDM group: 3.9%;P=0.511) . In hospital complications were as follows: death rate(DM group: 2.8%; NDM gr oup: 1.1%; P=0.680); stroke (DM group: 2 8%; NDM group: 1 7%; P=0 623 ); hemofiltratioin renal failure (DM group: 2.8%; NDM group: 0.5%; P=0.194); myocardial infarction(DM group: 0%; NDM group: 0.5%;P=1.000); blood using were more frequent in DM group comparied with NDM group (P=0.111). ConclusionOPCAB in diabetic patients is as safe as in non diabetic patients.

Access of safe, effective, convenient and affordable medical and health care services to the people is set as the goal of public hospitals health services as stated in the "Guidelines for Public Hospitals Pilot Reform". Such a goal, however, can hardly be achieved by mechanism changes within the public hospitals. The input and output of public hospitals rely critically on such factors as the input mechanism, regional pattern of healthcare system, the economic and industrial conditions of the region,payment quota and payment approval procedures of medical insurance. This paper set off from the input compensation mechanism of public hospitals in China and analyzed the input and output characteristics of the hospitals. Furthermore, the paper proposed to establish an input compensation mechanism based on public welfare performance for such hospitals. This provided further reference for improving the management of public hospitals and building a public welfare-oriented operation mechanism of public hospitals.

Acute Disease ; Adult ; Cardiomyopathies ; blood ; chemically induced ; diagnosis ; Creatine Kinase ; blood ; Female ; Humans ; Male ; Organophosphate Poisoning ; Pesticides ; poisoning ; Troponin I ; blood

Objective To probe into the effects of fluoride on metal elements in the testis tissue of male rats, and provide experimental basis to further research for reproductive toxicity of fluoride. Methods Thirty-two healthy male Wistar rats, weighting 150 - 180 g, were randomly divided into 4 groups, normal sodium(control) by intragastrie administration for 90 days, and body weight was observed daily. After the last intragastric administration, all rats were killed by cervical dislocation. The contents of calcium(Ca), ferri(Fe), zincum(Zn),cuprum(Cu ) and magnesium(Mg) in the testis tissue were measured by atomic absorption speetrophotometry.Results After 30 days exposure, the difference of body weight between groups was statistically significant(F=3.884, P < 0.05). The body weight in low- and medium-dose groups[(235.00 :t: 14.56), (235.44 ± 24.99)g] were significant increased than high-dose group[(206.00 ± 18.16)g, all P < 0.05]. There was no significant difference of body weight between the groups at 0, 60 and 90 days(F = 0.501, 0.578, 1.893, all P > 0.05). The difference of Ca, Zn and Mg levels among four groups was statistically significant(F = 6.630, 6.844, 5.333, all P < 0.05). The content of Ca of the low-dose group[(56.15 + 4.21 )mg/kg] decreased than that of the control group[(77.57 ± 6.66)mg/kg, P < 0.05];the content of Zn of the low-, medium- and high-dose groups[(4.80 ± 0.55), (4.56 ± 0.33),(5.46 ± 0.79 )mg/kg] deceased than that of the control group [(7.16 ± 0.28 )mg/kg, all P < 0.05];the content of Mg of the high-dose group [(32.44 ± 1.53 ) mg/kg] decreased than that of the control group [(42.54 ± 8.07 ) mg/kg,all P < 0.05]. The difference of testis Fe and Cu between four groups was not statistically significant(F = 1.324,0.207, all P > 0.05). Conclusion Chronic fluorosis can affect the levels of metal elements in rat testis and damage the reproductive system.

The rapid development of stomatology is improving the standard of talent quality and skills gradually,so the innovation of cultivation patterns of the stomatology students is imperative.West China College of Stomatology in Sichuan University is practicing the innovation of cultivation system of stomatological talents by establishing the new teaching and learning plan,adjusting the course system,strengthening the teaching materials construction,and adjusting the evaluation index and so on.The goal of the innovation of cultivation patterns is to foster the stomatological talents which have profound cultural atmosphere,the solid professional knowledge,strong innovative consciousness,and broad international vision.