With the development of MSCT and the widely applications of low-dose CT screening for lung cancer,the incidence of multiple primary lung cancer (MPLC),especially for which is characterized by ground glass opacity (GGO).However,the current clinicopathological criteria,molecular genetic technology and management strategies can not meet the needs of individualized demand.The latest progresses in the diagnostic aspects of MPLC,estrogen concentration in synchronous MPLC,molecular genetic characteristics,and management strategies of MPLC were reviewed in this paper.

0.05).The relative bioavailability of the test preparation was(96.47?10.43)%.CONCLUSION:The result demonstrated that the two formulations were bioequivalent.

Actins ; metabolism ; Adult ; Diagnosis, Differential ; Female ; Fibroma ; pathology ; Gastrointestinal Stromal Tumors ; pathology ; Humans ; Panniculitis, Peritoneal ; metabolism ; pathology ; surgery ; Peritoneal Neoplasms ; pathology

Public awareness of health always stays at the level of physical wellbeing,and there is a clear bound between disease and health.As the world health organization (WHO) put forward the new definition of health,health meant not only the absence of diseases and defects,but also psychological and physical health as well as good social adaptation ability,which updated public awareness of health.The viewpoint of “great health” advocated strengthening the overall situation and the strategic thinking,and promoted the resolution of current and long-term major health problems.This paper put forward the realistic meaning and realization approaches of the great health view by discussing the target of new health strategy.

The bcr-abl negative myeloproliferative neoplasms (MPN) include polycythemia vera (PV),essential thrombocythemia (ET) and primary myelofibrosis (PMF).Along with the detecting of JAK2 V617F gene mutation in MPN patients,a series of small molecules drugs that targeted to the mutation have been investigated in clinical trials.Ruxolitinib is the inhibitor of JAK1/2,which has been proved by USA Food and Drug Administration (FDA) and the European Medicines Agency (EMA) to treat patients with intermediate-2 or high-risk PMF or post-PV MF or post-ET MF and PV patients who are intolerant or resistant to hydroxycarbamide,attributed to a number of clinical trials,especially in COMFORT-Ⅰ and COMFORT-Ⅱ.As a result,the MPN patients have new hope for the treatment.

Computer technology is one of the greatest achievements of the 20th Century. Its appearance not only brings a breakthrough development in various fields, but also brings promotion to the development of traditional Chinese medicine (TCM). TCM is a traditional medicine, and the modernization of TCM is urgent. Whether in the medical management or scientific research, the application of computer technology has penetrated into all levels. The following article described the contribution made by computer technology, pointed out possible problems and provided relevant thinking based on the application of TCM related systems and data mining technology.

OBJECTIVE:To explore the significance of clinical pharmacists providing pharmaceutical care for pregnant patients with asthma in respiratory department. METHODS:Clinical pharmacists participated in the analysis of 2 cases of pregnancy complicating with asthma and applied pharmaceutical suggestion and therapy plan as penicillin anti-infective thera-py,intravenous dripping of magnesium sulfate combined with doxofylline,albuterol aerosol treatment instead. RESULTS:The asthma symptom had been relieved significantly and then the patients were discharged from the hospital after clinical phar-macists disposed the symptom appropriately. CONCLUSIONS:The participation of clinical pharmacists in pharmaceutical care for pregnant patients with asthma in respiratory department. Can improve the prognosis effectively and guarantee the safety of drug use.

OBJECTIVE:To study the preventive effects of arhinhor-11 on acute alcoholism in mice. METHODS:48 mice were randomly divided into model group (sodium carboxymethyl cellulose),arhinhor-11 low-dose,medium-dose and high-dose groups [1.23,2.46,4.92 g(crude drug)/kg],with 12 mice in each group. Each group was given relevant medicine intragastrically, and 30 min later given 56% liquor intragastrically to induce acute alcoholism model. The disappearance time and recovery time of righting reflex were determined. 160 mice were grouped,given medicine and modeled with the same method,with 40 mice in each group. The alcohol concentration and alcohol dehydrogenase(ADH)activity in liver of 10 mice were determined 0.5,1,2,3 h af-ter giving alcohol. Other 10 mice were included in normal control (ig administration of sodium carboxymethyl cellulose). RE-SULTS:Compared with model group,the disappearance time of righting reflex were prolonged while recovery time shortened in arhinhor-11 groups,and alcohol concentration and ADH activity increased 0.5,1,2,3 h after giving alcohol (P<0.05 or P<0.01),especially 1 h after giving alcohol. 3 h after giving alcohol,alcohol concentration in blood of arhinhor-11 high-dose group decreased while ADH activity increased (P<0.05);there was no statistical significance among other arhinhor-11 groups (P>0.05). CONCLUSIONS:Arhinhor-11 has preventive effect on acute alcoholism in mice. It has a positive control effects on the alco-hol concentration in blood and ADH activity in liver.

Objective To study the status quo and tendency of the utilization of antibiotics in our hospital in order to provide ref-erence for clinical rational drug use .Methods A retrospective analysis was performed on the consumption sum ,DDDs and defined daily cost(DDC) of antibiotics ,which taken from HIS system in drug storehouse from 2010 to 2013 .Results 2010~2013 ,the anti-microbial drug sales in proportion to the amount of drug sales were 35 .99% ,26 .47% ,14 .69% and 14 .52% respectively .Cephalo-sporins andβ-lactamase inhibitor have been in the forefront of the antimicrobial agents in the sales amount .The sales amount of Ce-foxitin sodium and Piperacillin/tazobactam has rapid grow th ,for three consecutive years of antimicrobial agents in the sales amount ordering frist and second .2010~2013 ,Cephalosporins and Macrolides antibiotics has been in the forefront on the sorting of DDDs . The DDDs of antifungal drugs increased year by year ,quinolones and nitroimidazoles was declining .The DDDs of Clarithromycin tablets ,Azithromycin enteric-coated capsules and Roxithromycin Capsules in the front row .2011-2013 ,the DDC of Cefuroxime in-creased the larger from 15 .37 to 68 .06 .Conclusion The antibacterial drug sales amount of drug sales amount is reduced year by year from 2010 to 2013 ,and the application of antimicrobial agents is given priority to Cephalosporins ,Antifungal drug sustained growth ,Macrolides antibiotics and Penicillins keep at a high level .

Based on the philosophical thinking of entropy and dissipative structures theory,it is of an important significance to solve the problems existing in medical education by combining it with humanistic education.In present paper,the comparison of Chinese-American medical humanity education and the influence of medicine development by those differences are shown according to the analysis of entropy and dissipative structures theory.Furthermore,the deficiencies of Chinese medical humanity education are demonstrated,and some primary methods solving these problems are put forward as well.