Objective To evaluate the quantity,category and the distribution of health resources of Traditional Chinese Medicine(TCM)in order to advise on optimizing TCM service system.Methods Based on the concept of agglomeration degree,this paper compared and analyzed the agglomeration of TCM resources in terms of medical institutions,their beds and medical workers.Results Currently the agglomeration degree of TCM health resources is found to be low,as TCM medical institutions tend to be small,with most of them being TCM clinics.Conclusions To rationalize the distribution of TCM medical resources,we must increase financial input and provide supportive policies,actively encourage healthy development of TCM medical institutions,strength TCM medical service system development in areas of poor TCM resources.

Fundus autofluorescence (FAF) relies primarily on the presence of accumulated lipofuscin in the retinal pigment epithelium (PRE) cells. It has emerged as a valuable tool to detect and evaluate the viability and structural changes of the RPE in live. As a non-invasive, repeatable, simple and efficient means of detection. FAF imaging can provide information of RPE structure and function to assistant the diagnosis of many retinal diseases with other conventional fundus imaging technologies. With quantitative analysis and complementary analysis with other fundus imaging technologies, the FAF features of different retinal diseases will be further understood. This knowledge will not only extend the reasonable and unique clinical applications of FAF, but also will contribute to the understanding the pathogenesis and improving the treatment of many retinal diseases.

This paper deals with the process of the reform and development of the social medical insurance scheme in urban China and the reasons for reform. At the same time, the paper presents the model of financing new urban employees' medical insurance in China.

Objective To study the effects of different dosages of valproic acid (VPA) in the disease onset, the level of motor dysfunction and survival time to the amyotrophic lateral sclerosis (ALS) model mice. Methods The ALS model mice (hSOD1-G93A gene positive) was screened and genotyped. Then,the model mice were random divided into treated groups( n = 18) and control group( n =6). The treated groups were i.p. injected with different dosage of VPA, but the control group was given isodose of saline. The assessment of the motor dysfunction stared from 12 weeks after birth and continued till death, the onset time and the survival time were recorded and compared. Results High dosage of VPA can prolong the onset time (9. 8 ± 1.4) days( P <0. 05), survival time ( 15.5 ±0. 9) days( P <0. 05), but it was not statistically significant to improve the motor dysfunction for the model mice. Compared with the control group,low and middle dosage of VPA were not statistically significant to prolong the onset time, the survival time for the model mice, and the level of motor dysfunction. Conclusions High dosage of VPA can delay the onset time of the ALS model mice and prolong the survival time, and which has neuroprotective effects against the neuronal degeneration in the hSOD1-G93A-gene-positive model mice.

Physiologically based pharmacokinetic model (PBPK), a mechanistic mathematic model, which can simulate the absorption, distribution, metabolism and excretion of drugs, is being more widely used in pharmaceutical research and development areas. This article reviews primarily the recent advances in the procedure of establishing a PBPK model, including specifying of the PBPK model structure, specification of the tissue model, writing of equations, set of model parameters, simulation and evaluation. Application significance, major challenges and future developments of PBPK model in pharmaceutical areas are also discussed.

Insufficient financial investments and insufficient raised funds are a common dilemma in mental health service worldwide .The primary sources of mental health financing worldwide are taxes , social insurance , and out-of-pocket expenditure by the patient or family .Government plays the primary role in fund raising .China has a low level of mental health service and poor equity in mental health financing as well as irrational allocation of funds . Mental health financing system in China should be improved by adding the financing system into mental health law and the outline of the central mental health work while making it clear that government , especially central govern-ment, is the main subject of mental health financing .Community mental health should also have the priority over fund allocation in order to increase the efficiency of raising funds .

Oral cancer is one of the most common malignant tumor of the head and neck.Passive targeting is a targeted therapy for initial treatment of oral cancer,which is not always effective.In order to achieve better targeted therapy on oral cancer,researchers have turned to the study of active targeting with nano drug delivery system in recent years.With this treatment,nanoparticles are attached to the surface of the target molecules,and combine with specific expression or overexpression receptor on the surface of tumor cell to achieve target.This delivery system can transport anticancer drugs directed at the lesion site and achieve the purpose of reducing adverse drug reaction and increasing treatment efficacy.Targeted chemotherapy is increasing being used in the treatment of oral cancer.

The G protein-coupled receptor family C,member 5,group A (GPRC5A) gene is known as retinoic acid-induced gene,which is mainly distributed in lung tissue.The expression of GPRC5A in lung cancer is significantly decreased compared with normal lung.GPRC5A leads to lung cancer through knockout mice,which is proven to be a suppressor gene of lung cancer.GPRC5A may be a novel biomarker for the diagnosis of lung cancer and a new target for the treatment of lung cancer.

Based on the organizational strategy,the balanced scorecard(BSC) is a kind of customized performance measurement system.Put forward by Robert Kaplan and David Norton in 1990,it has been using at several healthcare organizations and led to a great deal of innovation in organizing and management.This paper aims to introduce the composition,characteristics and successful cases of BSC,and analyze the feasibility of adopting this method in domestic healthcare organizations.

Objective To establish the evaluation system and explore the possible impact factors for public interest nature in public hospitals. Methods One hundred and twenty-five public hospitals in Zhejiang Province were served as sample hospitals, and related data of year 2004 to year 2006 were collected. The Delphi expert investigation method, variation coefficient method and TOPSIS method were employed to screen the impact factors for public interest nature and build up the evaluation system for public hospitals, and stepwise regression analysis was conducted for possible impact factors of public interest nature. Results The evaluation system mainly included five aspects of quantity, quality, efficiency, mean charge of medical service and social satisfaction to public hospitals. The two most important factors that influenced the public interest nature were the number of beds and the number of equipments valued above 10 000 RMB. Conclusion The hospital scale is the most important impact factor for the nature of public interest in public hospitals. Therefore, the scale of public hospitals should be properly designed so as to ensure the public interest nature in public hospitals.