Positive and meaningful exploration was conducted by related teachers to improve the teaching quality of oral clinical pharmacology.Case based teaching method was applied in the teaching of adverse reactions and bilingual teaching was employed in the teaching of local anesthesia.Correlation and comparison of the key knowledge points were emphasized in the teaching process. Students′ interests were aroused and satisfactory results were achieved through implementing these measures.

Objective:To develop an HPLC method for the content determination of paeoniflorin, tetrahydropalmatine and osthole in Gujinwan capsules. Methods:The determination was performed on an Eclipse XDB-C18 column (250 mm × 4. 6 mm,5 μm) with the mobile phase consisting of 0. 1％ phosphoric acid (adjusting pH to 6. 6 with triethylamine)-acetonitrile with gradient elution. The flow rate was 1. 0 ml·min-1 . The column temperature was 30 ℃. The detection wavelengths were set at 230 nm and 280 nm. Re-sults:The calibration curves were found to be linear within the range of 9. 56-33. 65 μg· ml-1 for paeoniflorin(r=0. 9998), 3. 65-12. 86 μg· ml-1for tetrahydropalmatine(r=0. 9999) and 5. 81-20. 45 μg· ml-1for osthole(r=1. 0000). The average recovery of paeoniflorin, tetrahydropalmatine and osthole was 98. 8％(RSD=1. 1％), 98. 4％(RSD=0. 8％) and 99. 1％(RSD=1. 4％)(n=6),respectively. Conclusion:The method is simple, accurate and reproducible, which can be used for the quality control of Gujinwan capsules.

Objective Observing the clinical effect of Ligustrazine Phosphate Tablets combined with percutaneous intratumoral injection of lipiodol THP on advanced hepa-tocellular carcinoma.Methods83 patients with advanced hepatocellular carcinoma from January 2012 to September 2014 were analyzed.Double-blind, randomized method All patients were divided into the control group 41 cases and observation group 42 cases.The control group were treatedwith percutaneous transhepatic intratumoral injection of lipiodol THP, the observation groupwere given Ligustrazine Phosphate Tablets combined with percutaneous intratumoral injection of lipiodol THP to treat.After treatment, the two groups of patients with treatment efficacy, adverse reactions and Karnofsky and prothrombin time were analyzed.ResultsAftertreatment, the efficacy of the two groups of patients were compared, the results showed that patients in the observation group total effective rate of the control group (χ2=4.034),the difference was statistically significant (P<0.05);two groups adverse reactions in patients after treatment were compared, liver pain, blood toxicity, fever, gastrointestinal reactions similar proportion of patients, the difference was not statistically significant;Theproportion of patients in the observation group AFP<8.1ng/mL was significantly higher (χ2=4.338), the difference was statistically significant (P<0.05);patients were observed after treatment Karnofsky score was significantly higher, the difference was statistically significant (t=7.141, P<0.05);after two groups of patients were compared prothrombin time, the difference was not statistically significant.ConclusionHepatic arterial chemoembolization and percutaneous intratumoral injection of THP lipiodol emulsion on the basis of the combination of Ligustrazine Phosphate Tablets can effectively improve the efficacy of treatment, and has good security, which is a safe and effective methods of treatment should be to promote and use in clinical.

In recent years,the study about the mechanisms of cell apoptosis has been increasingly concerned.Many liver diseases are correlated with caspase family,such as hepatic ischemia/reperfusion injury、inflammation and cancer,etc.In the article,we reviewed the importance of caspase family and the new research on the mechanisms of hepatic cell apoptosis in liver diseases.Meanwhile,we summarized the evidence concerned with apoptosis,and discussed the knowledge of therapeutic strategies.

OBJECTIVE To study the nursing strategies for the complications of peripherally inserted central venous catheter(PICC) used in patients with leukemia chemotherapy.METHODS Seventy-one patients with PICC for anti-leukemic chemotherapy were observed.The indwelling time of catheter varied from 1 month to 8 months.RESULTS Ten patients developed PICC related complications,3 phlebitis,3 infections,3 occlusions and 1 was with bleeding.CONCLUSIONS With the characteristics of easy operation,high safety and long time indwelling,PICC has been widely used in the chemotherapy of leukemia patients.To improve safety,the nusing strategies should on strictly sterile operation,application of correct veins and catheters,careful observation and nursing.

Objective To establish a gas chromatography method which will be suitable for determination of one time of the benzene, toluene, dimethylbenzene in the adhesives. Methods DMF was used for dissolving the sample, polyethylene glycol chrom-atographic column, hydrogen flames detector gas chromatography were employed to separate the compounds, determine the nature of serve time, quantify apex area. Results The contents of benzene, toluene, dimethylbenzene in gooey were 7.33-146.50, 7.23-144.50 and 7.21-144.20 mg/L respectively, with a good linear relativity (r=0.999), the rate of recovery were 96.45%-100.09%, 98.45%-100.76%, 97.81%-100.14%, the detection limits of the three chemicals were 0.22, 0.24 and 0.24 mg/L respectively, RSD were 1.60%-2.85% . Conclusion The method is accurate, feasible and suitable for determination of the benzene, toluene, dimethylbenzene in the adhesives.

Acid-sensing ion channels (ASICs), which are activated by extracelluar H+, are H+-gated cation channels. At present, seven subunits of ASICs family have been identified. Numerous studies revealed that ASIC1a plays important roles in synaptic transmission and plasticity,spatial learning and memory, nociception, as well as cerebral ischemia under physiological and pathological conditions. This review concerns the latest research about ASIC1a to promote the understanding of its physiological and pathological functions.

Although the optimal treatment protocol for clinical N2-stage non-small cell lung cancer (NSCLC) is still uncertain, the recommended standard treatment protocol goes to radical concurrent chemora diotherapy. Concurrent chemoradiotherapy after induction chemotherapy is not superior to standard concurrent chemoradiotherapy. Neoadjuvant concurrent chemoradiotherapy followed by pulmonary lobectomy can improve overall survival ratio comparaed with preoperative neoadjuvant concurrent chemoradiotherapy. The role of concurrent chemoradiotherapy followed by consooldation chemotherapy is still controversial. Gefitinib or erlotinib failed to bring about the survival benefit from the maintenance treatment after concurrent chemoradiotherapy. Prophylactic cranial irradiation play a role merely in decreasing the risk of brain metastases, but not in the improvement of overall survival.

Objective To analyze the related factors of medical order compliance in patients with chronic prostatitis. Methods 482 patients with chronic prostatitis were investigated by using the National Institutes of Health chronic prostatitis symptom index(NIH-CPSI)、Eysenck personality qusetionnaire( EPQ)and the self-de-signed medical order compliance questionnaire and the patients' disease characteristics and personality were also analyzed.The related factores of medical order compliance in patients were analyzed through hierarchical multiple regression analysis. Results Patients with chronic pwstatitis were younger and their disease condition was seri-ous. Their personality was introverted. They had many psychological problems, such as anxiety, depression, sus-pect, et al. All these were related with patients' compliance. Conclusions Attention should be paid to the patients' personality, and psychotherapy should be given to patients with introverted personality to improve pa-tients' compliance,so that the treatment effect will be increased for patients with chronic prostatitis.