No abstract available.
Animals ; Ligation* ; Neuralgia* ; Rats* ; Rhizotomy* ; Spinal Cord* ; Spinal Nerves*

Oligodendroglioma constitutes about 4% of all gliomas. The usual symptoms of oligodendrogliomas are seizures, focal neurologic deficits, and increased intracranial pressure. They usually present with a gradual onset of symptoms and slow progression. The apopletic symptom due to sudden tumor bleeding is rare. The author review literatures and present a case of oligodendroglioma initially manifested as ventricular hemorrhage after head injury.
Craniocerebral Trauma* ; Glioma ; Head* ; Hemorrhage* ; Intracranial Pressure ; Neurologic Manifestations ; Oligodendroglioma* ; Seizures

The authors report a case of falx meningioma which was first diagnosed with apopletic symptom due to intratumoral hemorrhage. A 72-year-old man was admitted to our hospital with a sudden deterioration of his level of consciousnesss down to a deep drowsiness, generalized seizure, and right hemiparesis. Radiological examinations, including brain CT(Computed Tomographic) scan and MRI(Magnetic Resonance Image) revealed a giant falx meningioma with intratumoral hemorrhage. During the operation the authors found a massive hemorrhage inside the tumor. Histologically, the tumor was meningotheliomatous meningioma and showed a hemorrhagic area with diffuse hemosiderin deposition. The authors also review the relevant literature and discuss the possible mechanism of hemorrhage in the meningioma.
Aged ; Brain ; Brain Neoplasms ; Hemorrhage* ; Hemosiderin ; Humans ; Meningioma* ; Paresis ; Seizures ; Sleep Stages

The esophageal lymphoma is a very rare feature among gastrointestinal lymphoma, and there was no surgical report in Korea. A 62-year-old male patient with submucosal tumor detected on routine esophagoscopy had resection of tumor including the esophageal mucosa, which was confirmed as esophageal lymphoma. As the severe leakage was detected on esophagogram on post-op 7th day, esophagectomy and esophagogastrostomy was followed. Though adjuvant chemotherapy was not performed, there were no evidence of recurrence for 1 year follow up. We experienced a patient with esophageal lymphoma and reported with brief review of literature.
Chemotherapy, Adjuvant ; Esophagectomy ; Esophagoscopy ; Follow-Up Studies ; Humans ; Korea ; Lymphoma* ; Male ; Middle Aged ; Mucous Membrane ; Recurrence

OBJECTIVE: Nitric oxide(NO) is implicated in a wide range of biological processes in tumors and is produced in glioma. To investigate the role of NO and its interaction with the tumoricidal effects of anticancer drugs, we study the antitumor activities of NO donors, with or without anticancer drugs, in human glioma cell lines. METHODS: U87MG and U373MG cells were treated with the NO donors sodium nitroprusside(SNP) and S-nitroso-N-acetylpenicillamine(SNAP), alone or in combination with the anticancer drugs 1, 3-bis(2-chloroethyl)-1-nitrosourea(BCNU) and cisplatin. Cell viability, cell proliferation, DNA fragmentation, nitrite level, and the expression of Bcl-2 and Bax were determined. RESULTS: NO was markedly increased after treatment with SNP or SNAP; however, the addition of the anticancer drugs did not significantly affect NO production. NO donors or anticancer drugs reduced glioma cell viability and, in combination, acted synergistically to further decrease cell viability in a dose- and time-dependent manner. Cell proliferation was inhibited and apoptosis were enhanced by combined treatment. Bax expression was increased by combined treatment, whereas Bcl-2 expression was reduced. The antitumor cytotoxicity of NO donors and anticancer drugs differed according to cell type. CONCLUSION: BCNU or cisplatin can inhibit cell viability and proliferation of glioma cells and can induce apoptosis. These effects are further enhanced by the addition of a NO donor which modulates the antitumor cytotoxicity of chemotherapy depending on cell type. Further biological, chemical, and toxicological studies of NO are required to clarify its mechanism of action in glioma.
Apoptosis ; Biological Processes ; Carmustine ; Cell Line ; Cell Proliferation ; Cell Survival ; Cisplatin ; DNA Fragmentation ; Drug Therapy ; Glioma* ; Humans ; Nitric Oxide Donors* ; Nitric Oxide* ; Sodium ; Tissue Donors

The cases of twenty-eight patients with spinal stenosis treated by microscopic decompressive surgery from January 1991 to September 1995, were analysed in an attempt to define is clinical feature, and to evaluate the results of our modified operation technique of preventing postoperative spinal instability. The main age group of the patients were in the fifties and sixties. On plain X-ray, most lumbar spine of the patients showed degenerative change. Pain in lower back and legs were the most common symptom, and intermittent neurogenic claudication was presented in three quarters of the patients. Radiologically, the diagnosis was confirmed by either myelography, CT, and MRI or by their combination. The major etiologic factors were thickening of ligamentum flavum, hypertrophy of laminae or facet joints and associated herniated nucleus pulposus. Since a significant rate of postdecompressive instability had been reported by other authors, therefore we have decided to performed less extensive decompressive total laminectomy procedure. The outcome of our decompressive laminectomy was favorable. In patients with no preoperative instability, newly developed instability following the less extensive decompressive total laminectomy was none.
Decompression* ; Diagnosis ; Humans ; Hypertrophy ; Laminectomy ; Leg ; Ligamentum Flavum ; Magnetic Resonance Imaging ; Myelography ; Spinal Stenosis* ; Spine ; Zygapophyseal Joint

Most cases of spinal subdural hematoma are very rare and result from iatrogenic causes, such as coagulopathy or a spinal puncture. Cases of non-traumatic spinal subdural hematoma accompanied by intracranial hemorrhage are even more rare. There are a few reports of spontaneous spinal subdural hematoma with concomitant intracranial subdural or subarachnoid hemorrhage, but not with intracerebral hemorrhage. Especially in our case, the evaluation and diagnosis were delayed because the spontaneous intracerebral hemorrhage accompanying the unilateral spinal subdural and subarachnoid hemorrhages caused hemiplegia. We report a case of spinal subdural and subarachnoid hemorrhage with concomitant intracerebral hemorrhage, for the first time, with a relevant literature review.
Cerebral Hemorrhage ; Diagnosis ; Hematoma ; Hematoma, Subdural, Spinal ; Hemiplegia ; Intracranial Hemorrhages ; Spinal Puncture ; Subarachnoid Hemorrhage

OBJECTIVE: The laboratory biomarkers used to diagnose spinal infection include white blood cell (WBC) counts, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP). Recently, procalcitonin (PCT) has been used as a biomarker to distinguish between bacterial infection and non-bacterial infection. We aimed to compare the changes of conventional biomarker and PCT in patients with spinal infection before and after antibiotic treatment. METHODS: ESR, CRP, WBC counts, and PCT were measured in 29 patients diagnosed with pyogenic spinal infection at our hospital between May 2016 and December 2018 prior to antibiotic administration. After antibiotic administration, the values were followed up for 4 weeks at 1-week intervals. RESULTS: A total of 29 patients were enrolled, with a mean age of 67.8 years, consisting of 16 men and 13 women. Twenty-five patients had lumbar infections, and 2 each had cervical and thoracic infections. The mean ESR, CRP, PCT, and WBCs decreased at week 4 of antibiotic treatment compared to their baseline values. CRP and WBCs were significantly decreased after 4 weeks of treatment compared to before treatment. The mean ESR and PCT was not statistically significant compared to pretreatment and after antibiotic treatment (p-value>0.05). CONCLUSION: Among several biomarker, CRP and WBCs are biomarkers that can aid early evaluation of the effects of antibiotic treatment in pyogenic spondylitis. Although PCT did not have statistical significance, it can be used as a biomarker that reflects the effect of antibiotic and severity of infection.
Bacterial Infections ; Biomarkers ; C-Reactive Protein ; Calcitonin ; Erythrocyte Count ; Female ; Humans ; Leukocytes ; Male ; Spondylitis

A retrospective review of 54 patients with multiple intracranial aneurysms seen over a 5 year period was performed. Among the 252 patients with aneurysms, the incidence of multiple aneurysms was 21.4%. Multiple aneurysms were slightly more common in women with a female to male ratio of 1.35:1. But there was no different ratio for patients with three or more aneurysms. Common clinical features were headache(96%), meningeal sign(83%), and change of consciousness level(52%). The most common Fisher's grade was III(63%), according to brain CT finding. Common locations of multiple aneurysms were the PcomA(35.7%), MCA(24.8%), AcomA(17.8%), and ICA bifurcation(7.7%). However, the aneurismal locations with the highest incidence of rupture were the MCA(53.1%). AcomA(52.1%), basilar bifurcation(50%). The PcomA(34.7%) was the least likely site for rupture. On the distribution of multiple aneurysms according to location, unilateral and midline located multiple aneurysms were 49%. Size was more important than irregularity of the shape in identifying the site of rupture. Most ruptured aneurysms were 5mm or larger in size. Postoperative mortality was 4.4% and the most common cause of postoperative mortality was cerebral vasoapasm.
Aneurysm ; Aneurysm, Ruptured ; Brain ; Consciousness ; Female ; Humans ; Incidence ; Intracranial Aneurysm* ; Male ; Mortality ; Retrospective Studies ; Rupture

The authors report a case of symptomatic choroid plexus cyst, located in the trigone of the left lateral ventricle in a 18-year-old man who presented with headache and seizure attack. The cyst was diagnosed by magnetic resonance image(MRI), and was confirmed with surgery. The cyst had no communication with the ventricular system orsubarachnoid space. Total removal of cyst adhering to the choroid plexus was accomplished, with subsequent disappearance of the seizure and headache. A brief review of the literature is included.
Adolescent ; Choroid Plexus* ; Choroid* ; Headache ; Humans ; Lateral Ventricles* ; Seizures