No abstract available.

No abstract available.
Adenoma* ; Toes*

No abstract available.
Atrophy* ; Brain*

No abstract available.
Lymphatic Diseases*

A solitary fibrous tumor (SFT) is a relatively uncommon neoplasm that usually occurs in the pleura. However, SFTs are now known to affect various other anatomic sites as well, including rare examples in the skin. Cutaneous SFT is composed of uniformly spindled cells, which is classically described as a patternless feature. This tumor can mimic a variety of benign and malignant mesenchymal neoplasms. The first patient presented with a 3x3 cm sized subcutaneous nodule on the neck. Histopathologically, the biopsy specimen showed proliferation of spindle cells and epitheliod cells. Immunohistochemical stains for CD34, vimentin, bcl-2, and CD99 were strongly expressed. The second patient presented with a 1.5x1 cm sized subcutaneous nodule on the occipital area. The biopsy specimen was histopathologically consistent with SFT. Primary SFT developing on the skin is extremely rare, and only two cases have been reported in the Korean literature. SFT should be distinguished from primary spindle cell neoplasms of the skin.
Biopsy ; Coloring Agents ; Humans ; Hydrazines ; Neck ; Pleura ; Skin ; Solitary Fibrous Tumors ; Vimentin

Extramammary Paget's disease (EMPD) is an uncommon intraepithelial neoplasm that most commonly arises on the vulva and perianal region. Very few cases of EMPD revealing a histological Bowenoid appearance have been reported. This study describes scrotal EMPD presenting with histological features of Bowen's disease in a 79-year-old man. He presented with a 5-year history of a pruritic erythematous plaque and a verrucous papule on the scrotum. The verrucous papule histopathologically showed Bowenoid features, and the erythematous plaque demonstrated acantholytic EMPD. Immunohistochemical findings revealed strong expression for carcinoembryonic antigen, Cam 5.2, epithelial membrane antigen, cytokeratin (CK) 7, and pancytokeratin (AE1/AE3) in both areas, but negative CK20 staining, supporting the overall diagnosis of primary acantholytic anaplastic EMPD. This is the first reported case of acantholytic anaplastic EMPD in the Korean literature.
Aged ; Bowen's Disease ; Carcinoembryonic Antigen ; Carcinoma in Situ ; Humans ; Immunohistochemistry ; Keratins ; Mucin-1 ; Paget Disease, Extramammary ; Scrotum ; Vulva

No abstract available.
Animals ; Blastocyst* ; Insulin* ; Mice*

No abstract available.
Umbilical Cord*

We report a rare case of adenoid basal carcinoma in uterine cervix. The patient was a 43-year-old Korean female. She received neoadjuvant chemotherapy with Quick Cis-VP16 (cisplatin and VP16 with 7-10 days interval), three times and radical hysterectomy with pelvic lymph nodes dissection under the diagnosis of cervical cancer stage IIa. After the neoadjuvant chemotherapy, the mass size was 3 x 2.5 Cm and which was protruded in exocervical region. Microscopically, scattered small nests of uniformed small cells with dark nuclei and scant cytoplasm were observed. Peripheral palisading as well as the formation of gland-like or acinar structures were noted. There were also foci of squamous differentiation in same portion of the small nests. The epithelial surface in other portions showed squamous cell carcinoma, large cell non-keratinizing cell type. Distribution between adenoid basal carcinoma of the cervix and other disease, such as adenoid cystic carcinoma and squamous cell carcinoma with basaloid features, is important for clinical management because the clinical behavior of adenoid basal carcinoma is less malignant than adenoid cystic carcinoma.
Adenoids* ; Adult ; Carcinoma, Adenoid Cystic ; Carcinoma, Squamous Cell ; Cervix Uteri* ; Cytoplasm ; Diagnosis ; Drug Therapy ; Etoposide ; Female ; Humans ; Hysterectomy ; Lymph Nodes ; Uterine Cervical Neoplasms

OBJECTIVE: The disintegration of extracellular matrix and basement membrane are important processes in the infiltration and metastasis of malignant tumors. We investigated the expressions of matrix metallo- proteinase-2 (MMP-2) and tissue inhibitors of metalloproteinases (TIMP-2) in tissues and sera from patients with cervical cancer, and compared the expressions of these enzymes with patient clinical status to determine the possibility of these enzymes being used as tumor biomarkers. METHODS : The expressions of MMP-2 and TIMP-2 were investigated in sixty cervical cancer tissues obtained from patients who were histologically confirmed having cervical cancer by immunohistochemical staining, and the expressions of the mRNAs of MMP-2 and TIMP-2 were confirmed by using RT-PCR. Also, the amounts of MMP-2 and TIMP-2 in sera obtained from each patient during treatment progress were measured using ELISA to determine the presence of a relationship between the expression levels of these enzymes and the clinical condition of the patient. RESULTS: In terms of the expression levels of MMP-2 and TIMP-2 by immunohistochemical staining, MMP-2 was shown to be positive in 46% (28/60) of the normal cervical tissues and in 75% (45/60) of the cervical cancer tissues, and the degree of expression of MMP-2 was also stronger in cervical cancer tissue than in normal cervical tissue. TIMP-2 was shown to be positive in 23% (14/60) and 27% (16/60) of normal cervical tissues and cervical cancer tissues, respectively, though these expressions were weak in nature. The mRNA of MMP-2 was more distinctly expressed in cervical cancer tissue than normal cervical tissue, but no difference could be seen in the case of TIMP-2. In terms of expressions as determined by ELISA, the positivity rate of MMP-2 in the normal control group and the cervical cancer group were 12% (7/54) and 76% (46/60), respectively, and the corresponding positivity rates of TIMP-2 were 22% (12/54) and 98% (59/60), respectively (p<0.05). MMP-2 expression reflected clinical condition in 57.5% of the patients, and TIMP-2 in 35%, however, MMP-2 expression increased in the presence of recurrent cervical cancer. CONCLUSIONS : MMP-2 and TIMP-2 are closely related with cervical cancer, and MMP-2 is believed a tumor biomarker that possibly reflects clinical status.
Basement Membrane ; Biomarkers ; Enzyme-Linked Immunosorbent Assay ; Extracellular Matrix ; Humans ; Matrix Metalloproteinase 2* ; Metalloproteases ; Neoplasm Metastasis ; RNA, Messenger ; Tissue Inhibitor of Metalloproteinase-2* ; Biomarkers, Tumor* ; Uterine Cervical Neoplasms*