1.Neonatal purpura fulminans due to homozygous protein C deficiency.
Jae Hong PARK ; Sung Suh SIM ; Soo Young KIM ; Hee Joo JEON ; Chan Yung KIM ; Hong Keun OH ; Jin Yeong JEONG
Journal of the Korean Pediatric Society 1992;35(5):696-703
No abstract available.
Protein C Deficiency*
;
Protein C*
;
Purpura Fulminans*
;
Purpura*
2.Initial experiences and usefulness of porcine acellular dermal matrix-assisted prepectoral breast implant surgery: a case series and systematic review
Chan Yeong LEE ; Woo Jin SONG ; Hyung Bo SIM ; Hyun Gyo JEONG ; Sang Gue KANG
Archives of Aesthetic Plastic Surgery 2023;29(2):76-88
Background:
We report our experiences with prepectoral placement breast implant surgery using Supporix (HansBioMed), a porcine acellular dermal matrix (PADM), for cosmetic and reconstructive indications. The clinical efficiency, safety, and cost-effectiveness of PADM were also discussed.
Methods:
A single-center, retrospective study was designed from December 2017 to December 2019. The participants were Korean women who underwent PADM-assisted prepectoral breast implant surgery performed by two surgeons. All complications were registered and analyzed. A systematic review and meta-analysis of complication rates after PADM-assisted prepectoral breast implant surgery were conducted for comparison with other studies. A subgroup analysis was performed according to the operation type: the cosmetic breast surgery (CBS) group, the immediate implant-based breast reconstruction (IIBR) group, and the delayed implant-based breast reconstruction (DIBR) group.
Results:
Twenty breasts in 16 patients were included in our study (median follow-up period, 8.25 months). In a systematic review, 20 publications with a total of 2,504 breasts in 1,921 women were quantitively analyzed. The overall complication rates in our study and other studies were 14% and 24% in the total group analysis, 0% and 12% in the CBS group, 62% and 26% in the IIBR group, and 0% and 28% in the DIBR group, respectively.
Conclusions
Our data support the effectiveness of PADM-assisted prepectoral breast implant surgery, which was comparable to other studies. PADM was effective for reducing seroma and hematoma in the revision CBS group and the DIBR group. In the IIBR group, it was helpful in preventing implant loss and explantation.
3.Percutaneous Retrieval of an Intravascular Catheter Embolus.
Yeong Hee HAM ; Seong Kyu JEONG ; Jin Hyuk JO ; Yeong Sin SIN ; Eun Hee SIM ; Min Gyu PARK ; Byung Soo KIM
Korean Journal of Medicine 2012;83(5):633-636
Intravascular catheter embolism is common and the most important complication of subclavian catheterization. The catheter fragment can lead to pulmonary embolism, vascular perforation, sepsis, arrhythmia, and even death. The intravascular foreign body can be removed using surgical or non-surgical methods. With technological advances, the percutaneous retrieval of intravascular foreign bodies has become a relatively common procedure. A commonly used method for retrieving intravascular foreign bodies is the loop snare. Sometimes biopsy forceps can be used. We experienced a case of non-surgical retrieval of an intravascular foreign body. We used the standard loop snare technique to remove a 5-cm catheter fragment from the left pulmonary artery.
Arrhythmias, Cardiac
;
Biopsy
;
Catheterization
;
Catheters
;
Embolism
;
Foreign Bodies
;
Pulmonary Artery
;
Pulmonary Embolism
;
Sepsis
;
SNARE Proteins
;
Surgical Instruments
4.A Case of Spontaneous Submucosal Dissection of the Esophagus Accompanying Mediastinal Abscess.
Seung Joon CHOI ; Kwang Jae LEE ; Young Bae KIM ; Jin Yeong SIM ; Ki Meong LEE ; Ki Baik HAHM ; Jin Hong KIM ; Sung Won CHO
Korean Journal of Gastrointestinal Endoscopy 2005;31(2):97-101
Spontaneous submucosal dissection of the esophagus (SDE) is a rare disease, in which spontaneous submucosal spot bleeding or intramural hematoma leads to the tearing of the layers between submucosa and muscle of the esophageal wall without any definitive cause, and the pathogenesis of SDE has not been well documented yet. Typical symptoms of SDE are chest pain, hematemesis, dysphagia, and odynophagia. The laboratory tests are usually normal and symptoms could be mild and ambiguous, so the diagnosis of SDE is conducted with endoscopy or esophagogram in most cases. The prognosis of SDE is usually very good with just conservative cares such as fasting and fluid therapy Esophageal perforation complicated by SDE is very rare because symptoms od SDE usually bring the patients to hospital before perforation. Recently, we experienced a case of a 54 year-old male showing the endoscopic findings of SDE and complicated mediastinal abscess probably following esophageal perforation. The patient had social history of chronic heavy alcoholic ingestion and had symptoms of substernal pain, dysphagia, and odynophagia. The patient recovered after partial esophagectomy, abscess drainage and antibiotic therapy.
Abscess*
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Alcoholics
;
Chest Pain
;
Deglutition Disorders
;
Diagnosis
;
Drainage
;
Eating
;
Endoscopy
;
Esophageal Perforation
;
Esophagectomy
;
Esophagus*
;
Fasting
;
Fluid Therapy
;
Hematemesis
;
Hematoma
;
Hemorrhage
;
Humans
;
Male
;
Middle Aged
;
Prognosis
;
Rare Diseases
5.Clinical Aspect of Spontaneous Pontine Hemorrhage.
Jin Sam PARK ; Woo Sung SUN ; Se Young PYO ; Moo Seong KIM ; Yeong Gyun JEONG ; Sun Il LEE ; Yong Tae JUNG ; Jae Hong SIM
Korean Journal of Cerebrovascular Surgery 2005;7(1):31-36
OBJECT: Spontaneous pontine hemorrhage can be diagnosed by CT or MRI, but the clinical course is variable according to the location of the hemorrhage. MATERIALS AND METHODS: Author attempted to analyse 39 cases of spontaneous pontine hemorrhage, considering factors to influence their prognosis, admitted in Inje University Busan Paik Hospital from 1998 to 2002. RESULT: Pontine hemorrhage was classified according to the finding of CT scan;4 cases of Type I (hematoma, localized in the tegmentum), 18 cases of Type II (those in the tegmentolaterally), 16 in Type III (those in the basis pontis mainly with tegmentum and midbrain). Male to female ratio was 31:8, mean age was 48.2 years (9-76 years). Initial Glascow Coma scale was 7.6 (3-14), and mean follow-up period was 5.1 months (0.1-52 months). Associated diseases were as follows;hypertension;20, pulmonary tuberculosis;2, hypertension with D.M;1. Treatment modality was consisted of 36 conservative treatment, 1 stereotactic hematoma aspiration, 2 Gamma-Knife radiosurgery for associated cavernous malformations. Prognosis was good at following order of the tegmentotectal, tegmentolateral type. CONCLUSION: The prognosis of tegmentotectal, tegmentolateral type hemorrhage was better than basis pontis. The little volume of the hematoma, the better prognosis.
Busan
;
Coma
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Female
;
Follow-Up Studies
;
Hematoma
;
Hemorrhage*
;
Humans
;
Hypertension
;
Magnetic Resonance Imaging
;
Male
;
Prognosis
;
Radiosurgery
6.Three Cases of Intracranial Hematoma Associated with Meningioma.
Jin Seok JEONG ; Moo Seong KIM ; Sun Il LEE ; Yong Tae JUNG ; Soo Chun KIM ; Jae Hong SIM ; Yeong Il YANG
Journal of Korean Neurosurgical Society 1998;27(10):1412-1418
Spontaneous intracranial hematoma in patients with brain tumors is well recognized, However, intracranial hematoma associated with meningioma has been rarely reported. Not infrequently, clinical manifestations of such tumors have been masked by the associated hematoma, which preclude correct diagnosis of these tumors. Meningioma-associated hemorrhages have been reported regardless of sex, age, or location and histology of the tumor. The mechanisms of such hemorrhage are yet to be clarified. During the last two years, we have experienced three cases of intracranial hemorrhage associated with meningioma. Two of them occurred acutely without antecedent symptoms of the meningioma and other one after gamma knife surgery of meningioma. We reviewed partinent literature and discussed possible mechanisms of these rare intratumoral or peritumoral hemorrhages associated with meningiomas.
Brain Neoplasms
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Diagnosis
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Hematoma*
;
Hemorrhage
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Humans
;
Intracranial Hemorrhages
;
Masks
;
Meningioma*
7.Overview of anaphylaxis in Korea: diagnosis and management.
Gwang Cheon JANG ; Yoon Seok CHANG ; Sun Hee CHOI ; Woo Jung SONG ; Soo Young LEE ; Hae Sim PARK ; Hye Ryun KANG ; Yeong Min YE ; Hyun Jung JIN ; Mi Yong SHIN ; Soo Jin LEE ; Hye One KIM ; Jihyun KIM ; Jae Woo JUNG ; Hee Bom MOON ; Youngmin AHN
Allergy, Asthma & Respiratory Disease 2013;1(3):181-196
Anaphylaxis is a medical emergency and all healthcare professionals need to be familiar with its diagnosis, acute management, long-term management including prevention of future episodes, and plan for patient education. Correct diagnosis and management for anaphylaxis is critical, but it is not easy in clinical setting. Up to the present, several practical guidelines for anaphylaxis are available for the practitioners. Among them, World Allergy Organization guideline for the assessment and management has recently been released and widely used. In this article, we reviewed and summarized the epidemiology, risk factors, diagnosis, management, prevention, and education based on case reports and studies of anaphylaxis in Korean and other countries. Although there are many controversies, this practical overview for anaphylaxis would provide a clinical guidance for Korean healthcare professionals.
Anaphylaxis
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Delivery of Health Care
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Emergencies
;
Hypersensitivity
;
Patient Education as Topic
;
Risk Factors
8.Predictive Factors for Long-term Clinical Outcomes in Patients with Variant Angina.
Myung Ja CHOI ; Myung Ho JEONG ; Jae Yeong CHO ; Young Sook LEE ; Jung Ae RHEE ; Jin Su CHOI ; Doo Sun SIM ; Keun Ho PARK ; Young Joon HONG ; Ju Han KIM ; Young Keun AHN ; Jeong Gwan CHO ; Jong Chun PARK ; Jung Chaee KANG
Korean Journal of Medicine 2013;84(4):522-530
BACKGROUND/AIMS: The incidence of variant angina (VA) is relatively high in Korea compared with western countries, but its long-term clinical outcomes are not well defined. METHODS: Patients who underwent ergonovine provocation tests at the cardiac catheterization laboratory of Chonnam National University Hospital between 1996 and 2011 were enrolled in this study (n = 1162). Of them, 686 patients with positive ergonovine provocation tests were divided into two groups: patients with cardiac events (Group I: 153 patients, 52.4 +/- 11.0 years, M: F = 103: 50) and those without (Group II: 533 patients, 51.6 +/- 10.7 years, M: F = 350: 183). The mean follow-up duration was 40.2 +/- 38.0 months. Cardiac events were defined as cardiac death, recurrent ischemia, rehospitalization, myocardial infarction, and follow-up angiography. Clinical findings, laboratory and coronary angiographic characteristics were compared between the groups. RESULTS: A history of smoking was more common in Group I than in Group II (45.8% vs. 36.3%, p = 0.037). The levels of low-density lipoprotein cholesterol (119.4 +/- 35.3 vs. 111.1 +/- 32.2 mg/dL, p = 0.010) were higher in Group I than in Group II. According to Cox proportional hazard regression analysis, the major predictive factor for cardiac events during clinical follow-up was smoking (HR 1.80, 95% CI 1.036-3.126, p = 0.037). CONCLUSIONS: A history of smoking was the only independent risk factor for cardiac events during a long-term clinical follow-up in Korean patients with variant angina.
Angina Pectoris, Variant
;
Angiography
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Cardiac Catheterization
;
Cardiac Catheters
;
Cholesterol
;
Coronary Artery Disease
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Death
;
Ergonovine
;
Follow-Up Studies
;
Humans
;
Incidence
;
Ischemia
;
Korea
;
Lipoproteins
;
Myocardial Infarction
;
Risk Factors
;
Smoke
;
Smoking
9.Clinical characteristics and outcomes in acute myocardial infarction patients with versus without any cardiovascular risk factors
Ah Ra CHOI ; Myung Ho JEONG ; Young Joon HONG ; Seok Joon SOHN ; Hyun Yi KOOK ; Doo Sun SIM ; Young Keun AHN ; Ki Hong LEE ; Jae Yeong CHO ; Young Jo KIM ; Myeong Chan CHO ; Chong Jin KIM ;
The Korean Journal of Internal Medicine 2019;34(5):1040-1049
BACKGROUND/AIMS:
Although cardiovascular (CV) risk factors are well established, some patients experience acute myocardial infarction (AMI) even without any risk factors.
METHODS:
We analyzed total 11,390 patients (63.6 ± 12.6 years old, 8,401 males) with AMI enrolled in Korea Acute Myocardial Infarction Registry-National Institute of Health from November, 2011 to December, 2015. Patients were divided into two groups according to the presence of any CV risk factors (group I, without risk factors, n = 1,420 [12.5%]; group II, with risk factors, n = 9,970 [87.5%]). In-hospital outcomes were defined as in-hospital mortality and complications. One-year clinical outcomes were defined as the composite of major adverse cardiac events (MACE).
RESULTS:
Group I was older (67.3 ± 11.6 years old vs. 63.0 ± 12.7 years old, p < 0.001) and had higher prevalence of female gender (36.2% vs. 24.8%, p < 0.001) than the group II. Group I experienced less previous history of angina pectoris (7.0% vs. 9.4%, p = 0.003) and the previous history of cerebrovascular accidents (3.4% vs. 6.9%, p < 0.001). In-hospital mortality (2.6% vs. 3.0%, p = 0.450) and complications (20.6% vs. 20.0%, p = 0.647) were no differences between the groups. And 1 year clinical outcomes (5.7% vs. 5.1%, p = 0.337) were no differences between the groups. In multivariate logistic regression analysis, serum creatinine level (hazard ratio, 1.35; 95% confidence interval, 1.05 to 1.75; p = 0.021) were independent predictors of 1 year MACE in patients without any CV risk factors.
CONCLUSIONS
Elderly female patients were prone to develop AMI even without any modifiable CV risk factors. We suggest that more intensive care is needed in AMI patients without any CV risk factors who have high serum creatinine levels.
10.18F-THK5351 PET Positivity and Longitudinal Changes in Cognitive Function in β-Amyloid-Negative Amnestic Mild Cognitive Impairment
Min Young CHUN ; Jongmin LEE ; Jee Hyang JEONG ; Jee Hoon ROH ; Seung Jun OH ; Minyoung OH ; Jungsu S. OH ; Jae Seung KIM ; Seung Hwan MOON ; Sook-young WOO ; Young Ju KIM ; Yeong Sim CHOE ; Hee Jin KIM ; Duk L. NA ; Hyemin JANG ; Sang Won SEO
Yonsei Medical Journal 2022;63(3):259-264
Purpose:
Neuroinflammation is considered an important pathway associated with several diseases that result in cognitive decline. 18F-THK5351 positron emission tomography (PET) signals might indicate the presence of neuroinflammation, as well as Alzheimer’s disease-type tau aggregates. β-amyloid (Aβ)-negative (Aβ–) amnestic mild cognitive impairment (aMCI) may be associated with non-Alzheimer’s disease pathophysiology. Accordingly, we investigated associations between 18F-THK5351 PET positivity and cognitive decline among Aβ– aMCI patients.
Materials and Methods:
The present study included 25 amyloid PET negative aMCI patients who underwent a minimum of two follow-up neuropsychological evaluations, including clinical dementia rating-sum of boxes (CDR-SOB). The patients were classified into two groups: 18F-THK5351-positive and -negative groups. The present study used a linear mixed effects model to estimate the effects of 18F-THK5351 PET positivity on cognitive prognosis among Aβ– aMCI patients.
Results:
Among the 25 Aβ– aMCI patients, 10 (40.0%) were 18F-THK5351 positive. The patients in the 18F-THK5351-positive group were older than those in the 18F-THK5351-negative group (77.4±2.2 years vs. 70.0±5.5 years; p<0.001). There was no difference between the two groups with regard to the proportion of apolipoprotein E ε4 carriers. Interestingly, however, the CDR-SOB scores of the 18F-THK5351-positive group deteriorated at a faster rate than those of the 18F-THK5351-negative group (B=0.003, p=0.033).
Conclusion
The results of the present study suggest that increased 18F-THK5351 uptake might be a useful predictor of poor prognosis among Aβ– aMCI patients, which might be associated with increased neuroinflammation (ClinicalTrials.gov NCT02656498).