Objective:To discuss the role of Fas/FasL-mediated colonic epithelial apoptosis in the pathogenesis of ulcerative colitis(UC).Methods:Expression of Fas,FasL and M30(a new epithelium apoptosis marker) antigen on colonic mucosa of 35 patients with UC and 15 control populations were detected by IHC.Each marker was analyzed by image analysis system.Co-expression of Fas and M30 was observed through serial sections and double staining IHC.Results:The expression of Fas,FasL as well as M30 in UC increased considerably compared with controls (P

Adult ; Aged ; Aged, 80 and over ; China ; epidemiology ; Female ; Humans ; Incidence ; Male ; Middle Aged ; Pneumoconiosis ; epidemiology

Delayed cerebral vasospasm is the leading cause of death in patients with subarachnoid hemorrhage. A good in vivo animal model of cerebral vasospasm after subarachnoid hemorrhage helps to understand the occurrence, development of this cerebral vasospasm, and the complicated and various pathophysiological mechanisms. It will provide important information for clinical interventions

Objective:To observe oncosis in human peripheral blood T lymphocytes.Methods:Peripheral blood T lymphocytes of healthy adult was separated with Percoll(1.073 g/ml)and harvested by using nylon column.The cultured cells were divided into control and dexamethasone(DXM)group,and cell morphology was observed through light microscope,electron microscope and fluorescent microscope.And incidence rate of oncosis was analyzed by flow cytometry.Results:①Oncosis could be observed in cultured T lymphocyte after 96h.②In different concentrations of DXM group(1?10-6,1?10-5,1?10-4,1?10-3mol/L),The incidence of oncosis T lymphocytes was(3.49?0.42)%,(5.17?0.48)%,(8.44?0.72)%,(17.93?1.50)%.③During different cultured period(48,72,96,120h),The oncositic rate of T lymphocytes in DXM group was(0.53?0.10)%,(6.36?0.80)%,(20.60?1.59)%,(25.56?1.76)%.Conclusion:Oncosis can be seen in human peripheral blood T lymphocytes,and DXM could induce oncosis.

The development of renal transplantation from living relative donors relives the shortage of transplanted organs,and benefits patients with end-stage renal diseases.However,when seen from the aspect of donors,implementing a non-therapeutic invasive surgical treatment on a healthy person still violates the absolute sound principle of medical ethics.To reduce the harm to the minimum,a comprehensive assessment should be conducted before the transplantation,and long-term follow-up observations after transplantation should also be strengthened.

Objective To summarize the application and advancement of liver transplantation for hepatic metastasis from neuroendocrine tumor. Methods Domestic and overseas publications on the study of liver transplantation for hepatic metastasis from neuroendocrine tumor in recent years were collected and reviewed. Results Liver transplantation can offer good relief of symptoms, long disease-free intervals, and potential cure in individual patients with hepatic metastatic tumor. Important selection criteria are well-differentiated tumors and a low proliferation rate (Ki67

Periodontal ligament stem cells(PDLSCs) are not only the crucial type of cells in maintaining dynamic homeostasis and wound repair of periodontal tissues but also the basis for novel therapeutic strategy for periodontal regeneration.Although possessing the excellent proliferation and differentiation ability,PDLSCs behave differently under various conditions representative of several influential factors.Understanding of these influential factors will help us to exploit more about PDLSCs,and more importantly,lead a new modality in treating periodontal diseases based on stem cells.Here we review multiple important factors affecting function of PDLSCs and propose its use in future regenerative therapy of periodontal defects.

ObjectiveTo explore the effect of Songlingxuemaikang combined with losartan on the blood pressure and quality of life in female patients with menopausal hypertension.Methods87 female patients with menopausal hypertension were randomly divided into combined group (Songlingxuemaikang combined with losartan group,44 cases) and the control group(losartan alone,43 cases).Before and after treatment the ambulatory blood pressure (ABMP) was monitored for 24h,and blood lipids and clinical symptoms were observed.ResultsAfter two months treatment,the blood pressure variability and nighttime blood pressure decrease rate of the combination group significantly reduced,and better than those of the control group( all P ＜0.05) ;The effective rate and efficiency rate of the combination group were 90.9％,63.6％ respectively,and was higher than 74.4％,39.5％ in the control group( x2 =4.15,5.06,all P ＜ 0.05 ).The clinical symptoms improving,total cholesterol ( TC ) reducing,density lipoprotein (LDL-C) lowing in the combination group was superior to the control group( all P ＜ 0.05).ConclusionSonglingxuemaikang combined with losartan in treatment of female patients with menopausal hypertension had a good antihypertensive effect,and could reduce blood pressure variability in menopausal women,improve the symptoms of menopause and lipid metabolism,incresse the quality of lfie of patients with menopausal hypertensive.

Objective To investigate the regulating effect of Jianpixiaoshi Decoction(JPXSD)on gastrointestinal motility in rats of functional dys-pepsia(FD)with spleen deficiency syndrome. Methods Forty healthy male SD rats were randomly divided into four groups:normal control group, model group,model traditional Chinese medicine(TCM)group and model western medicine group. Except for the normal control group,FD model of spleen-deficiency type was established by swimming to exhaustion on alternate days and alternating feeding of cabbage and lard for 25 days. Corre-sponding drugs were then administrated to those four groups:distilled water,JPXSD and Mosapride distilled water solution once a day by gavage for 7 days. Symptoms and body weights of these rats were observed and recorded during the experiment. After the last of drug administration,all groups were fasted for 24 hours. Nutritious semisolid paste marked with ink was given orally to the rats,GER and IPR of 1 hour were detected under anesthe-sia by sodium thiopental and blood were collected at the same time. The concentration of serum SP and SS were measured by ELISA according to the instructions. Results JPXSD improved the symptoms of model rats. Model TCM group showed significantly increased body weight,higher GER, lower IPR,higher serum SP level and lower SS level when compared to model group(P<0.05). Conclusion JPXSD could improve the symptoms of rat with spleen-deficiency,raise its body weight,accelerate the decreased gastric emptying and bring back the hyperactive small intestinal move-ment to normal. The regulating role of JPXSD may be realized through the increase of serum SP level and decrease of SS level.

Atherosclerosis (AS) is a multi-factor disease,with complex etiology.It is associated with vascular abnormalities and changing vascular wall composition.AS mainly involve large and medium sized arteries,which may cause multiple organ lesions including heart and brain tissue ischemia and necrosis,myocardial infarction,stroke and other serious diseases.Its pathogenesis has not been finally clarified.This article gives review on pathological changes,etiology and mechanism of AS,as well as its imaging performance.