No abstract available.

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Animals ; Immunohistochemistry* ; Neurons* ; Rats* ; Substantia Nigra*

No abstract available.
Animals ; Humans* ; Mice* ; Muramidase* ; Paneth Cells* ; Rats*

OBJECTIVE: The purpose of this study was to evaluate the MR spectrum and MR cholangiographic imaging findings of clonorchiasis. MATERIALS AND METHODS: We reviewed 26 patients with confirmed clonorchiasis by either stool tests (n=24) or surgery (n=2). MR imaging was performed on a 1.5 T system (GE Medical Systems, Milwaukee, WI) with a torso coil. Axial T1-and T2-weighted, gadolinium-enhanced dynamic images and MR cholangiography were obtained. Image analyses were used to identify abnormalities of the intrahepatic and extrahepatic bile ducts and the presence of hepatobiliary malignancy. All MR examinations were reviewed by the consensus of two abdominal radiologists. RESULT: Intrahepatic bile duct abnormalities were seen in 23 (89%) of the 26 patients. The most common finding was mild dilatation of the intrahepatic bile duct which was found in 21 (81%). "Too many intrahepatic ducts" were found in 16 (62%), wall enhancement and thickening in 21 (81%) and filling defects and ductal stricture in the intrahepatic bile duct in 6 (24%) and 3 (12%) patients, respectively. Extrahepatic ductal dilation was found in 5 (19%) and 9 (35%) revealed hepatobiliary malignancy. CONCLUSION: MR imaging revealed various findings of clonorchiasis, including dilatation, wall enhancement, stricture of the intrahepatic ducts and filling defect within the intrahepatic bile duct.
Adult ; Aged ; Cholangiography/methods ; Clonorchiasis/*diagnosis/radiography ; Female ; Human ; *Magnetic Resonance Imaging/methods ; Male ; Middle Aged

No abstract available.
Pheochromocytoma* ; Pregnancy*

A gene p53, which is a tumor suppressor gene located on chromosome 17p, regulates cell growth and proliferation, and inactivation of this gene appears to be a common abnormality in many malignant tumors in human. To investigate the prevalence and patterns of p53 protein overexpression and the significance of the p53 protein overexpression as a marker for poor prognosis in transitional cell carcinoma of the bladder which were treated with radical cystectomy, fifty deparaffinized archival specimens from radical cystectomy for transitional cell carcinoma of the bladder were analyzed immunohistochemically to detect overexpression of p53 protein using the mouse monoclonal antibody DO-7 with a standard avidin-biotin immunoperoxidase method. The incidence of p53 expression was 17 of50 (34 per cent) specimens. The p53 expression was associated with histopathologic grade but not with T stage and the status of lymph node involvement. There was no evidence of high recurrence rate, metastasis rate or low survival rate in patients with p53 positive group compared to p53 negative group. But the patients with p53 positive group showed higher T stage and shorter mean survival time than those with p53 negative group. It was not statistically significant. Among many variables evaluated with multivariate analysis, T stage was a significant factor in terms of metastasis, while the status of lymph node involvement was a significant one in terms of survival. In conclusion, the incidence of p53 gene mutation appeared to be higher in invasive and high grade bladder cancer than in superficial and low grade ones. The p53 expression failed to show an unfavorable prognostic factor in transitional cell carcinoma of the bladder treated with radical cystectomy. Prospective studies of large cohorts of specimens are needed to evaluate nuclear overexpression of p53 protein as a prognostic marker in bladder cancer.
Animals ; Carcinoma, Transitional Cell* ; Cohort Studies ; Cystectomy* ; Genes, p53 ; Genes, Tumor Suppressor ; Genes, vif ; Humans ; Incidence ; Lymph Nodes ; Mice ; Multivariate Analysis ; Neoplasm Metastasis ; Prevalence ; Prognosis ; Recurrence ; Staphylococcal Protein A ; Survival Rate ; Urinary Bladder Neoplasms ; Urinary Bladder*

Though the occurrence of multiple primary malignant tumor is a rare finding but the reported cases of it has increased in recent years. We collected multiple primary cancer of different organ, tissue and the multicentric origin of bilaterally paired organs. This paper reports 6 cases of multiple primary malignant tumors which were experienced at Yeungnam university hospital in Taegu during the past 2 years with review of journals. The results were as follows. 1. The incidence of multiple primary cancer was 0.31% for 2 years (1987-1988). 2. The ratio between male and female was 1:1 and mean age of incidence was 54.1 years. 3. The ratio between synchronous and metachronous (interval more than 6 months) was 1:1. 4. The time interval between first and second cancer was average 2.7 years in metachronous cases. 5. The most frequent involved organ was stomach, breast and colon in order of frequency. 6. The incidence of familial cancer associations was found in one out of 6 cases. 7. The test of DNCB, multitest CMI and ratio of T4 to T8 were performed in 4 cases but there was no definitive evidence of abnormality. We concluded that every effort should be made to discover the presence of synchronous malignancies in the patients who are being treated for a known tumor, and also special care should be given to detect new metachronous lesions is required.
Breast ; Colon ; Daegu ; Dinitrochlorobenzene ; Female ; Humans ; Incidence ; Male ; Neoplasms, Second Primary ; Stomach

No abstract available.
Neoplasm Metastasis*