No abstract available.
Epidemiology* ; Mycoplasma pneumoniae* ; Mycoplasma* ; Pneumonia, Mycoplasma*

No abstract available.
Asthma*

Monilethrix is a rare hereditary disorder of hair first described by Walter G. Smith in 1879, and usually transmitted as autosomal dominant trait. It is characterized hy bead like enlargement af the affected hair, alapecia resulting from ha.ir breakage and keratosis pila.l is. This 3 year old female child patient has been suffered from easy destrurtion of beaded scalp hair and follicular hyperkeratosis of the occipital region since infancy. Past hiatory was ncecontributory and the pe,digree of family showed autosomal dominant trait. Physical examinatior was not rernarkable except skin lesian and laboratory findings were within normal limit. Microscopic finding of the affected hair showed alternating constrictians and node. The scalp bivpsy findings showed mild hyperkeratosis, keratotic plug, mild cellular infiltration of papillary derrnia and perifollicular area.
Child ; Child, Preschool ; Female ; Hair ; Humans ; Keratosis ; Monilethrix* ; Scalp ; Skin

Congenital ectodermal dysplasia are a group of familial disorders that affect tissues and organs of ectodermal origin to varying degrees. It devided hidrotic type and anhidrotic type by geneologic origin and distinct clinical manifestationa. The hidrotic type usually trait by autosomal dominant gene and manifested dystrofic nails, defect of hair and eyebrow and palmoplantar hyperkeratosis. This patient is 16 year oId male. He had been dystrophic nails, alopecia since at birth, thereafter palmoplantar hyperkeratosis, clubbing fingers noted. C.R.C. Urinalysis, stool examination, chest x-ray were within normal limit. Biopsy specimen from palm revealed hyperkeratosis, hypergranulosis, acanthosis and, mild inflamrnatory cell infiltrate on upper dermis. Biopsy speeimen from the scalp revealed norrriaI findings except slight hypoplasia of ebaceaus gland.
Alopecia ; Biopsy ; Dermis ; Ectoderm ; Ectodermal Dysplasia* ; Eyebrows ; Fingers ; Genes, Dominant ; Hair ; Humans ; Male ; Parturition ; Scalp ; Thorax ; Urinalysis

Subungual exostosis is a solitary fibrus nodule on the inner border of the terminal phalanx of the great toe. Rarely, the terminal phalanges of other toes, particularly the little toe, or even the fingers are involved. The first appearance is a small pinkish growth projecting slightly beyond the inner free edge of the nail, which pushes upward and backward. A case of Subungual exostosis affecting 20 year old man, who has been suffering from bean sized nolule on subungual area of terminal phalanx of left 5th toe. The skin iesion developed 1 year ago, and increased size insidiously and tendemess on pressure or tight shoes was noted. Diagnosis was confirmed by histopathologic and radiologic studies, and treated witb complete excision of tumor mass.
Diagnosis ; Exostoses* ; Fingers ; Humans ; Shoes ; Skin ; Toes ; Young Adult

The eosinophil is the major cell responsible for the inflammatory reaction in bronchial asthma. Secretion of granular components is probably of considerable importance for the inflammatory effects of the eosinophils. Eosinophil cationic protein (ECP) is the one of the secretory components of the eosinophil granule and-is considered as an activation marker of eosinophil count, serum concentration of ECP and serum IgE were studied in normal, symptomatic and asymptomatic asthmatic children. In symptomatic asthma, peak expiratory flow rate (PEFR) was studied and methacholine challenge test was done in asymptomatic asthma in addition. Blood eosinophil count and serum ECP in asthma were significantly raised compared with those of the normal children. And the level of serum ECP in symptomatic asthma was higher than that in asymptomatic asthma. The mean % fall of PEFR was significantly correlated with serum ECP and blood eosinophil count in symptomatic asthma. In asymptomatic asthma, there was no correlations between methachloine PC20 and blood eosinophil count or methachloine PC20 and serum ECP level. Our findings show that blood eosinophil count and serum ECP levels differ not only between normal children and asthmatic children, but also between symptomatic asthma and asymptomatic asthma.
Asthma ; Child* ; Eosinophil Cationic Protein* ; Eosinophils* ; Humans ; Immunoglobulin E ; Methacholine Chloride ; Peak Expiratory Flow Rate

Recently, a benign variant of scleroderma, called the C.R.S. T, syndrome, has ben ibed by Winterbauer. Patients with this disorder have skin changes such as Cermal and subr,utaneous calcinosis, Raynauds phenomenon, sclerodactyly, and te1angiectasia. With the passible exception. of the gastroirgestinal syaterh, involvernent of other organs is uncommon, and affected. individuals have a Iong clinical cgurse. A case of C.R.S.T. syndrome in 25-year-old femala in reported with brief reviev of literatures. The patient showed miultiple pea sized nodular depoaits on dermal and subcuta.neous layers of both elbow and. knee joints, Rayaauds phenamenon, sclerrodactyly with acroselerosis and sclerodermatous change on both hands and forearm and telangiectasia on face and both palms On eeophagogram, slight disturhance of passage at the cardioesophageal junetion area was noted.
Adult ; Calcinosis ; Elbow ; Forearm ; Hand ; Humans ; Knee Joint ; Peas ; Skin ; Telangiectasis

Herpes simplex virus infections, with their increasing tendenes are one of the most common infectious diseases. But there have been no systematic investigations on the prevalence of HSV antibodies according to ages in Korea. We therefore decided to investigate this prevalence using micro-neutralization tests. Blood samples were collected from 502 randomly selected men and women, 5 months to 77 years of age who were outpatients or hospitalized patients at the Hanyang University Hospital between 1990-1991. Students at the Hanyang university college of medicine, and other volunteers were also tested. All of the serum samples were assayed for antibodies to HSV useing the microneutralization test. The Cos strain of HSV 1 and the YHS 2-1 strain of HSV 2 were use3 in our study. The antibody titers were expressed as the highest serum dilution causing 80% plaque reduction. The individuals with a neutralizing antibody titer of 1: 2 or higher to HSV 1 were regardel as having the antibody to HSV l. To determine HSV 2 antibody activity, the II/I index was used (II/I mdex : log HSV1 antibody titer/log, HSV 2 antibody titer, lI/I index >0.85) The results obtained were the followings : 1. HSV 1 antibodies were found at a relatively high rate in young a es and its prevalence gradually increased with age. 2. HSV 1 antibody titers iricreased with age. 3. HSV 2 antibodies were not found in children under 11 years of ae but were found in teenagers at a relatively low rate. The prevalence tended to increas with age. 4. HSV 2 antibody titers showed a higher value in those over 31 years of age.
Adolescent ; Antibodies ; Antibodies, Neutralizing ; Child ; Communicable Diseases ; Female ; Herpes Simplex* ; Humans ; Korea ; Male ; Outpatients ; Prevalence* ; Simplexvirus* ; Volunteers

No abstract available.
Clinical Laboratory Techniques* ; Mycoplasma Infections* ; Mycoplasma*

A case of Epidermolysis Bullosa Dystrophica is reported with review of pathogenesis with literatures. Epidermolysis Bulloaa Dystrophica is a rare genetic disease which is characterized by the formation of blister upon the minor trauma or friction to the skin. A 7-year old boy was referred to our dept. in Aug. 1976 because of a severe bullous eruption primarily on his hands and feet. On admission tense bullae were noted on the dorsa of hands and feet which is usually serous but may be hermorhagic tendency. Soon thereafter tbis bullous lesion tend to break down into painful shallow denudation which may leave depigmented scars and milia after healing. Family history was negative for skin disorders.
Blister ; Child ; Cicatrix ; Epidermolysis Bullosa Dystrophica* ; Epidermolysis Bullosa* ; Foot ; Friction ; Hand ; Humans ; Male ; Skin ; Transcutaneous Electric Nerve Stimulation