1.Gorham's Syndrom: A Case Report
Han Koo LEE ; Young In LEE ; Jin Sup YEOM
The Journal of the Korean Orthopaedic Association 1990;25(6):1793-1798
Gorham's syndrome (Gorham's disease, Massive osteolysis, Disappearing bone disease, phantom bone) is a rare disorder characterized by histologically benign proliferation of thin-walled vascular channels originating in bone associated with extensive lysis of regional bone matrix. It starts in bone, but it may secondarily involve soft tissues and adjacent bones. Although the osteolysis usually arrests spontaneously, its biologic behavior is unpredictable. The etiolgy is still in dispute and the treatment presents many problems. The author's case was a 20-year old girl, who had pathologic fracture in neck and supracondylar area of left femur with osteolysis of left pelvis, femur, and proximal fibula and tibia. She also had lymphangioma involving bones and adjacent soft tissues. To our knowledge, there is no report on Gorham's syndrome in Korea. The authors report a case of Gorham's syndrome with review of literatures.
Bone Matrix
;
Dissent and Disputes
;
Female
;
Femur
;
Fibula
;
Fractures, Spontaneous
;
Humans
;
Korea
;
Lymphangioma
;
Neck
;
Osteolysis
;
Osteolysis, Essential
;
Pelvis
;
Tibia
2.The Role of Absorbable Pins in the Treatment of Fractures
Moon Sang CHUNG ; Sang Hoon LEE ; Kang Sup YOON ; Jin Sup YEOM
The Journal of the Korean Orthopaedic Association 1990;25(3):753-763
Since 1954 when the first biodegradable polymer, polyglycolic acid(PGA), was synthesized, many different biodegradable and tissue-tolerant materials have been invested and studied for internal fixation devices. The use of biodegradable materials for the internal fixation of fractures would avoid the need for later removal of the implant. However, problems of a physical and chemical nature have delayed the development of biodegradable implants applicable to fracture management. The authors reviewed 17 cases in which the absorbable pins made of poly-p-dioxanone were used for internal fixation at Seoul National University Hospital between December, 1987 and September, 1989, and report on 11 patients who had at least 6 months follow-up(average 9.1 months). The results were graded as excellent(5 cases), good(4 cases), poor(0 case), and questionable(2 cases). In the 9 cases where the absorbable pins were used for internal fixation of the intraarticular fractures or defects, satisfactory(excellent or good) results were obtained. In the 2 cases where the absorbable pins were used for intramedullary nailing, the role of the pins was questionable. There were no complications such as wound sinus formation, secondary displacement of the fragemts and delayed union or nonunion.
Absorbable Implants
;
Fracture Fixation, Intramedullary
;
Humans
;
Internal Fixators
;
Intra-Articular Fractures
;
Polymers
;
Seoul
;
Wounds and Injuries
3.Cyclin D1 Protein Expression is Inversely Correlated with p53 Protein in Primary and Recurrent Transitional Cell Carcinoma of the Urinary Bladder.
Min Jin LEE ; Sun Hee SUNG ; Woon Sup HAN
Korean Journal of Pathology 2000;34(12):1009-1015
Transitional cell carcinoma of the urinary bladder is the most common cancer of the urinary tract and is characterized by frequent recurrence. Like the other malignant tumor, the genetic alterations leading to neoplastic transformation of the urothelium are related with the activation of oncogenes and loss of functional tumor suppressor genes. Cyclin D1 is a putative protooncogene as cell cycle regulator essential for G1 phase progression and is frequently overexpressed in several human tumor. In this study we performed immunohistochemical stainings of cyclin D1 and p53 in both primary and recurrent transitional cell carcinomas of urinary bladder from 56 patients including 20 cases of recurrent tumor, and compared their results with histopathologic features. The results were as follows. Cyclin D1 immunoreactivity was found in 10 of 10 cases (100%) of grade 1, 25 of 41 (61%) cases of grade 2, and 11 of 25 (44%) cases of grade 3 transitional cell carcinomas. p53 immunoreactivity was found in 40% of grade 1, 63% of grade 2, and 87% of grade 3 lesions. Cyclin D1 expression was significantly higher in Ta and T1 lesions than T2 to T4 by pathologic tumor stage. Conversely p53 immunoreactivity was increased in proportion to the T classification. Cyclin D1 was de creased in recurrent transitional cell carcinomas, compared with primary transitional cell carcinomas. However, there was no statistical significance. In conclusion, cyclin D1 immunoreactivity is associated with low histologic grade and low tumor stage. And there is inverse relationship between the cyclin D1 and p53 overexpression.
Carcinoma, Transitional Cell*
;
Cell Cycle
;
Classification
;
Cyclin D1*
;
Cyclins*
;
G1 Phase
;
Genes, Tumor Suppressor
;
Humans
;
Oncogenes
;
Recurrence
;
Urinary Bladder*
;
Urologic Neoplasms
;
Urothelium
4.Effect of the Isolation Method of Mouse Inner Cell Mass, Types of Feeder Cells and Treatment Time of Mitomycin C on the Formation Rate of ICM Colony.
Ho Jin JANG ; Kyung Rae KO ; Mi Kyung KIM ; Yong Jin NA ; Kyu Sup LEE
Korean Journal of Fertility and Sterility 2006;33(4):265-272
OBJECTIVE: This study was carried out to evaluate the effect of the isolation methods of inner cell mass from mouse blastocyst, types of feeder cells and treatment time of mitomycin C on the formation rate of ICM colony. METHODS: The inner cells were isolated by conventional immunosurgery, partial trophoblast dissection with syringe needles and whole blastocyst co-culture method. Commercially available STO and primary cultured mouse embryonic fibroblast (pMEF) feeder cells were used, and mitomycin C was treated for 1, 2 or 3 hours, respectively. The formation rate of ICM colony was observed after isolation of ICM and culture of ICM on the feeder cells for 7 days. RESULT: The ICM colony formation rate on STO were significantly higher in partial trophoblast dissection group (58%) than that in immunosurgery (12%) or whole blastocyst culture (16%) group (p<0.05). The formation rate on pMEF feeder layer was higher in partial trophoblast dissection (88%) and whole blastocyst culture (82%) group than that in immunosurgery (16%) group (p<0.05). When mitomycin C treated to pMEF for 2 hours, the formation rate of 88% was significantly higher than those of other conditions. CONCLUSIONS: Above results showed that the efficient isolation method of ICM from blastocyst was the partial trophoblast dissection and the appropriate treatment time of mitomycin C was 2 hours. However, the subculture of ICM colony and characterization of stem cells should be carried out to confirm the efficacy of the partial trophoblast dissection method.
Animals
;
Blastocyst
;
Coculture Techniques
;
Feeder Cells*
;
Fibroblasts
;
Mice*
;
Mitomycin*
;
Needles
;
Stem Cells
;
Syringes
;
Trophoblasts
5.Correction of severe foot deformity using ilizarov external fixator.
In Ho CHOI ; Duk Yong LEE ; Chin Youb CHUNG ; Jin Sup YEOM ; Chang Seop LEE
The Journal of the Korean Orthopaedic Association 1992;27(3):611-624
No abstract available.
External Fixators*
;
Foot Deformities*
;
Foot*
6.Reconstruction of the hip koint in old unreduced developmmental dislocation of the hip in late childhood and adolescence.
Duk Yong LEE ; In Ho CHOI ; Chin Youb CHUNG ; Young In LEE ; Jin Sup YEOM ; Han Soo KIM
The Journal of the Korean Orthopaedic Association 1992;27(4):880-889
No abstract available.
Adolescent*
;
Dislocations*
;
Hip*
;
Humans
7.Analysis of Biomechanical Properties of Whole Cervical Spine under Static Loading with 3-D Finite Element Model.
Choon Ki LEE ; Jin Sup YEOM ; Young Eun KIM ; Sang Hoon LEE ; Bong Soon CHANG
The Journal of the Korean Orthopaedic Association 1998;33(7):1889-1896
The biomechanical responses, such as nucleus pulposus pressure, facet contact force, stress distribution among ligaments in the cervical spine under static loading like flexion and extension, were examined with 3-D nonlinear finite element model. Finite element model consisted of whole cervical spines with intact discs and ligaments was developed from 1mm thick CT-cross sections of a 25-year-old healthy young man. Geometrical nonlinearity was considered for the large deformation and ABAQUS package was used for calculation. Results were verified comparing with those of existing in vivo and in vitro experiments. Results indicated that, developed cervical spine FEM was well consistent with other experiments. Nucleus pulposus pressure increased in flexion and extension more in lower cervical region. Facet contact force increased more in lower cervical spine in extension. In addition, capsular ligament was the most important one among 7 cervical ligaments surrounding cervical spine both in flexion and extension. We could better understand the biomechanics of whole cervical spine with developed finite element model and it might be applied to dynamic or postoperative study.
Adult
;
Humans
;
Ligaments
;
Spine*
8.A case report of hemifacial microsomia.
Chang Kon LEE ; Myung Jin LEE ; Jong Sup KIM ; Jin Ho PARK ; Byung Rho CHIN ; Hee Kyung LEE
Yeungnam University Journal of Medicine 1993;10(1):218-225
This is a case report and review of literature that deals with hemifacial microsomia corrected by costochondral graft, Lefort I osteotomy and bilateral intraoral sagittal split ramus osteotomy. Patient, 23 years old female, had visited to treat the esthetic problem due to a deviation of jaw. On the basis of clinical and radiographic examinations, she was diagnosed as hemifacial microsomia. First, costochondral graft was performed to bridge the defect between glenoid fossa and body of mandible. After 11 months,. Patient was performed a Lefort I osteotomy and bilateral intraoral sagittal split ramus osteotomy to create a symmetric jaw. Patient was satiesfied with final esthetics and there have been no evidence of infection ill now.
Esthetics
;
Female
;
Goldenhar Syndrome*
;
Humans
;
Jaw
;
Mandible
;
Osteotomy
;
Osteotomy, Sagittal Split Ramus
;
Transplants
9.The comparison of influence of difficulties in nasal breathing on dentition between different facial types.
Myeong Jin LEE ; Chang Kon LEE ; Sup Jong KIM ; Jin Ho PARK ; Byung Rho CHIN ; Hee Kyung LEE
Yeungnam University Journal of Medicine 1993;10(1):37-47
It is. commonly assumed that nasorespiratory function can exert a dramatic effect upon the development of the dentofacial complex. Specially, it has been stated that chronic nasal obstruction leads to mouth breathing, which causes altered tongue and mandibular positions. If this occurs during a period of active growth, :the .outcome is development of the "adenoid facies". Such patients characteristically: manifest a vertically long lower third facial height, narrow alar bases, lip incompetence, a long and narrow maxillary arch and a greater than normal mandibular plane angle. But several authors have reported that so-called adenoid facies is not always associated with adenoids and mouth breathing, and that a particular type of dentition is not alwarys found in mouth breathers with or without adenoids. Some authors have believed adenoids lead to mouth breathing in cases with particular facial characteristics and types of dentition. We assumed that the ability to adapt to individual's neuromuscular complex is various. So, we compared the difference of influence of mouth breathing between childrens who have different facial types. This study included 60 patients and they were divided into three groups by Rickett's facial type. Their dentition and tongue position were compared. The results are as follows. 1. There is a significant difference in arch width of upper molars between different facial types. Especially dolichofacial type patients have narrowest arch width. 2. There is a significant difference in tongue position between different facial types. Especially dolichofacial type patients have lowest positioned tongue.
Adenoids
;
Child
;
Dentition*
;
Facies
;
Humans
;
Lip
;
Molar
;
Mouth
;
Mouth Breathing
;
Nasal Obstruction
;
Respiration*
;
Tongue
10.Studies on Scintillation Proximity Assay for the mesurement of alpha - hCG.
Tae Hyun CHOI ; Chang Woon CHOI ; Sang Moo LIM ; Wee Sup CHUNG ; Soo Jeong LIM ; Su Jin LEE ; Tae Sup LEE ; Ok Doo AWH ; Kwang Sun WOO
Korean Journal of Nuclear Medicine 2002;36(2):133-139
No abstract available.