1.Metformin Preserves Peripheral Nerve Damage with Comparable Effects to Alpha Lipoic Acid in Streptozotocin/High-Fat Diet Induced Diabetic Rats
Sun Hee KIM ; Tae Sun PARK ; Heung Yong JIN
Diabetes & Metabolism Journal 2020;44(6):842-853
Metformin is widely marketed medication for the treatment of diabetes, but its pharmacological effect on diabetic peripheral neuropathy remains unclear. In this study, the effect of metformin on peripheral nerves in diabetic rats was investigated using diverse neuronal parameters of nerve fibers. Rats were assigned to one of four groups ( Both DM+metformin and DM+ALA groups showed similar trends to diverse sensory tests at 24 weeks compared to DM group although the degree of change were different according to the stimulated senses. There was no significant difference in the comparison of the intraepidermal nerve fiber density (IENFD) of peripheral nerves between the DM+metformin and DM+ALA groups (11.83±0.07 fibers/mm vs. 12.37±1.82 fibers/mm, respectively). Both groups showed preserved IENFD significantly compared with DM group (8.46±1.98 fibers/mm, Metformin has beneficial pharmacological effects on the preservation of peripheral nerves in diabetic rats and its effects are comparable to those of ALA.
2.Development of a CD-ROM Titled 'Atlas of Pathology' for Medical Students.
Dong Sug KIM ; Yong Jin KIM ; Sun Woo PARK
Korean Journal of Pathology 2000;34(5):374-380
The authors have made a CD-ROM titled 'Atlas of Pathology (AP)' for medical students to understand histopathologic findings with ease. We used a 35 mm film scanner to convert an existing file into digital images. A pathologist and two professional programmers collaborated to create the program 'AtlasMaster 1.0' based on (IBM) PC for organization of previously captured digital images. Minimum system requirement for the 'AP' was Pentium II 166 MHz, 32 MB RAM, Windows 95 or 98, 800 600 resolution, 16-bit color, 20 speed CD-ROM drive. The 'AP' was composed of a execution file (Pathology_Atlas.exe), a DB file (pathology.mdb), and reference files (*.bmp, *.jpg, *.txt). The DB file contained fields for chapter, section, disease entity, and information for location of reference files. About 1,000 color images for various kinds of gross and microscopic pictures were stored in the CD-ROM and those were classified according to the chapters, sections, and disease entities. The 'AP' was easy to manipulate, and had advantages of self-learning for students. It could be applied to other fields in which many images were dealt with, such as histology, radiology, endoscopy, dermatology, and plastic surgery. The 'AP' was handy and very useful for medical students to study pathology and it would be a powerful self-learning tool.
CD-ROM*
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Dermatology
;
Endoscopy
;
Humans
;
Pathology
;
Students, Medical*
;
Surgery, Plastic
3.Characterization of Principal Component Cell of DMBA induced Rat Malignant Fibrous Histiocytoma With Cell Culture and Cloning.
Myeng Sun PARK ; Hae Jin JEONG ; Man Ha HUH
Korean Journal of Pathology 1997;31(6):574-585
This experiment was performed to elucidate the cytologic origin of chemically induced MFH in Wistar rats. The tumor was produced by injections of DMBA(9,10-dimethyl-1,2-benzanthracene). With the produced MFH, cell culture and cloning were performed, followed by establishment of a cell strain, which was investigated by immunohistochemical and electron microscopic studies. The results were as follows. A) By immunohistochemistry of the tumor tissue, fibroblastic cells were positive for MEP-1(specific antibody for fibroblastlike cell of MFH, Takeya, 1993) and Anti-hPH(beta)(Anti-prolyl 4-hydroxylase beta), but negative for TRPM-3 and F4/80. Histiocytelike cells were positive for TRPM-3 and F4/80, but negative for MEP-1 and Anti-hPH(beta). In immunoelectron microscopy, normal spleen macrophage showed linear reactivity in cell membrane for TRPM-3, whereas histiocytelike cells of the tumor disclosed negative reaction. B) At 5 weeks of the primary tumor cell culture, the cells exhibited typical storiform pattern of MFH. C) The established cell strain revealed immunoreactivity for MEP-1 and Anti-hPH(beta), but negative for TRPM-3. The cloned tumor cells showed morphologic characteristics of undifferentiated fibroblastic cell. Latex particle (0.80 micrometer size) phagocytosis was negative in the cloned cell strain. The results of the current study support the concept that principal component cells of MFH is of fibroblastic cell origin.
9,10-Dimethyl-1,2-benzanthracene*
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Animals
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Cell Culture Techniques*
;
Cell Membrane
;
Clone Cells*
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Cloning, Organism*
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Fibroblasts
;
Histiocytoma, Malignant Fibrous*
;
Immunohistochemistry
;
Macrophages
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Microscopy, Immunoelectron
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Microspheres
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Phagocytosis
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Rats*
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Rats, Wistar
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Spleen
4.Klebsiella pneumoniae Cellulitis Associated with Osteomyelitis was Suspected by Highly Elevated Inflammatory Marker Serum Procalcitonin.
Sang Hyun PARK ; Jin Kyung CHAE ; Sun Yong KWON ; Kun PARK ; Seok Don PARK
Korean Journal of Dermatology 2014;52(5):362-363
No abstract available.
Cellulitis*
;
Klebsiella pneumoniae*
;
Osteomyelitis*
5.Dermatomyositis Associated with Follicular Lymphoma.
Jin Kyung CHAE ; Sang Hyun PARK ; Sun Yong KWON ; Seok Don PARK ; Kun PARK
Korean Journal of Dermatology 2015;53(7):564-566
No abstract available.
Dermatomyositis*
;
Lymphoma, Follicular*
6.Nevus Lipomatosus Cutaneous Superficialis with Ectopic Sebaceous Glands on the Neck.
Sun Yong KWON ; Jin Kyung CHAE ; Sang Hyun PARK ; Seok Don PARK ; Kun PARK
Korean Journal of Dermatology 2015;53(1):82-84
No abstract available.
Neck*
;
Nevus*
;
Sebaceous Glands*
7.Pilar Sheath Acanthoma on Dorsum of Nose.
Sang Hyun PARK ; Jin Kyung CHAE ; Sun Yong KWON ; Seok Don PARK ; Kun PARK
Korean Journal of Dermatology 2015;53(8):654-655
No abstract available.
Acanthoma*
;
Nose*
8.Early Colorectal Cancer.
Jae Bum LEE ; Young Jin PARK ; Kyu Joo PARK ; Sun Whe KIM ; Jae Gahb PARK ; Kuhn Uk LEE ; Yong Hyun PARK ; Kuk Jin CHOE ; Jin Pok KIM
Journal of the Korean Society of Coloproctology 1998;14(3):375-384
Purpose : Early colorectal cancer is defined as the depth of tumor invasion limited to mucosa or submucosa regardless of the presence or absence of lymph node metastasis. We performed a retrospective study to determine the chronological changes in frequencies of early colorectal cancer and clinicopathologic differences between early colorectal cancer (ECC) and advanced colorectal cancer (ACC). Methods : We reviewed hospital records of the patients with colorectal cancer operated between January 1990 and December 1995. We classified the patients into two groups, ECC and ACC, according to the depth of tumor invasion and compared the clinicopathologic characteristics. Results : Fifty eight patients (5.2%) were diagnosed with early colorectal cancer among 1113 colorectal cancer patients operated at the same period. The frequency of ECC has increased from 1.9% in 1970~1989 to 5.2% in 1990~1995. The average age of patients with ECC at the time of surgery was 55.8 compared to 56.5 for patients with ACC group (p>0.05). Most patients (72.4%) with ECC had bleeding symptoms and majority of the ECCs were located in the rectum (72.4%). The mean size of tumors was 2.6 cm in its greatest diameter and was significantly smaller than that of ACC (5.7 cm). Compared to ACC, ECC had better histologic differentiation and fewer lymph node metastases (p<0.05). Thirty six of the ECC patients underwent bowel resection and remaining 22 underwent local excision. After a mean follow up period of 39.1 months (range 2~81months), recurrence was detected in one case. There was no death during the follow up period. Conclusion : The frequency of ECC has increased recently. Compared to patients with ACC, patients with ECC had more favorable clinicopathologic characteristics and better outcome. In selected patients, minimal operation can be applied without compromising the clinical outcome.
Colorectal Neoplasms*
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Follow-Up Studies
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Hemorrhage
;
Hospital Records
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Humans
;
Lymph Nodes
;
Mucous Membrane
;
Neoplasm Metastasis
;
Rectum
;
Recurrence
;
Retrospective Studies
9.Pleomorphic Adenoma of the Bronchus: A case report.
Eun Sun PARK ; Mi Kyung JEE ; Seok Jin GANG ; Byung Kee KIM ; Sun Moo KIM
Korean Journal of Pathology 1989;23(1):136-140
Pleomorphic adenoma presenting as primary lesion of the bronchus is very rarely encountered, and in our knowledge only 6 cases have been reported in the literature of the western world, and no case report has been published in Korea. Currently, we experienced a case of bronchial pleomorphic adenoma occuring in a 38 years old woman. On X-ray examination, hazy density in the right upper lobe and emphysematous change in the right lower lobe were noted. A right pneumonectomy was done under bronchoscopic diagnosis of bronchial adeoma. The pathologic examination of the present case showed a polypoid endobronchial tumor, 1.4 x 1.1 cm (with extraluminal portion, 2.2 x 1.7 cm) in the right upper bronchus. The microscopic examination revealed a pleomorphic adenoma showing same morphology as those found in the salivary gland. This case, therefore, was believed to be a genuine example of bronchial pleomorphic adenoma of salivary gland type. We compared this case with 6 cases in the literature.
Female
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Humans
;
Adenoma
10.Endoscopic Removal of Traumatic Intracerebral Hematoma via Superolateral Keyhole.
Sung Jin PARK ; Ho Gyun HA ; Ho JUNG ; Sang Keol LEE ; Moon Sun PARK
Journal of Korean Neurosurgical Society 2000;29(2):249-254
No abstract available.
Hematoma*