1.Inhibition effect of growth of clostridum pereringens by enterococc-us faecalis.
Wan Shik SHIN ; Jin Hong YOO ; Moon Won KANG
Korean Journal of Infectious Diseases 1992;24(2):93-98
No abstract available.
2.Inhibition effect of growth of clostridum pereringens by enterococc-us faecalis.
Wan Shik SHIN ; Jin Hong YOO ; Moon Won KANG
Korean Journal of Infectious Diseases 1992;24(2):93-98
No abstract available.
3.A case of typhoid fever complicated by complete AV block, myocarditis and pancreatitis.
Yoo Bae AHN ; Yang Lee KIM ; Jin Hong YOO ; Wan Shik SHIN ; Moon Won KANG
Korean Journal of Infectious Diseases 1993;25(3):245-248
No abstract available.
Atrioventricular Block*
;
Myocarditis*
;
Pancreatitis*
;
Typhoid Fever*
4.Children with Congenital Hypothyroidism, Diagnosed After 1 Month of Life.
Jin Soon HWANG ; Se Young KIM ; Kye Shik SHIM ; Choong Ho SHIN ; Sei Won YANG
Journal of Korean Society of Pediatric Endocrinology 1998;3(1):73-78
PURPOSE: Congenital hypothyroidism(CH) is not uncommon disorder, leading to retardation of mental development and growth, if not treated early. The aim of this study is to determine the factors influencing IQ of children with CH, diagnosed after 1 month of life. METHODS : Thirteen children with CH were included. They had intelligence test by KEDI-WISC(Korean Educational Development Institute-Wechsler Intelligence Scale for Children) and their medical records were reviewed. Their T4, TSH, height, age at diagnosis were investigated retrospectively. To evaluate the influence of T4, TSH, height, age at diagnosis on IQ, children were divided into three groups ; athyroid(n=8), sublingual(n=3), inborn errors of thyroid hormone synthesis(n=2) according to the result of thyroid scan. Results : In athyroid group, IQ closely correlated to VIQ and PIQ and had close relationship to T4 at diagnosis(.p=0.0086, r=0.8427), but no relation to TSH. There was no difference in height, T4 TSH, and IQ between athyroid and sublingual group. CONCLUSION : The results suggest that intellectual function in children with CH, diagnosed after 1 month of life depends on serum level of T4 at diagnosis. Further study is mandatory to elucidate the relationship between final IQ and factors, including thyroid function, age at diagnosis, adequacy of treatment, etc.
Child*
;
Congenital Hypothyroidism*
;
Diagnosis
;
Growth and Development
;
Humans
;
Intelligence
;
Intelligence Tests
;
Medical Records
;
Retrospective Studies
;
Thyroid Gland
5.Safety and immunogenicity of the typhoid Vi capsular polysaccharide vaccine.
Wan Shik SHIN ; Moon Won KANG ; Dae Kyoon KO ; Jin Han KANG
Korean Journal of Infectious Diseases 1991;23(3):145-153
No abstract available.
Typhoid Fever*
6.Current Opinion in the Treatment of Opportunistic Fungal Infections.
Korean Journal of Medical Mycology 1997;2(1):9-16
Opportunistic fungal infections are significant causes of mortality and morbidity especially among the immunocompromised hosts. There is now increasing array of drugs available for their treatment. Amphotericin B is the most established and widely used antifungal agent and lipid-complexed amphotericin B preparations are introduced recently. The imidazole and triazole drugs have specific roles to play on the management of these patients. However, antifungal therapy is still limited by the lack of effective agents, lack of early diagnostic techniques to identify infection in its early stages and the developement of resistance. There are also few comparative studies of drugs within the increasing number of antifungal agents which would Provide a reliable basis for choice.
Amphotericin B
;
Antifungal Agents
;
Humans
;
Immunocompromised Host
;
Mortality
7.Effects of Locally Applicated Safflower Seeds Extract on Bone Regeneration of Rat Calvarial Defects.
Doek Kyu KIM ; Sung Woo HONG ; Kyung Tae YOU ; Jae Jin SEO ; Heung Shik KIM ; Hyung Keun YOU ; Hyung Shik SHIN
The Journal of the Korean Academy of Periodontology 1999;29(2):297-310
The ultimate goal of periodontal treatment is the regeneration of periodontal tissues which have been lost due to periodontal disease. Recently, many natural medicines have been studied for their potential of anti-bacterial, anti-inflammatory and regenerative effects in periodontal tissues. Safflower seeds have been traditionally used as a drug for treatment of fracture and blood stasis in oriental medicine. The objective of the present study is to examine the biologic effects of safflower seeds extract on bone formation and regeneration of rat calvarial defects. The calvarial defects were made with 8mm trephine bur and extract of safflower seeds were placed directly at these defects. 24 rats were divided into control and experimental groups, and each group was sacrificed at 1 week, 4 weeks and 8 weeks. To study a histopathology related to bone regeneration, Goldner's Masson Trichrome stain and histomorphologic measuring was done at each weeks. In the early phase of bone healing, less inflammatory infiltration and capillary proliferation was found in experimental group compared to control. Dense bony tissues and matured bone structures in defect areas were found in experimental groups. And area of new bone formation was significantly increased at 8 weeks in experimental group. These results indicate that direct local application of safflower seeds extract reduces the early inflammatory response and promotes the regeneration of new bone in calvarial defects of rats.
Animals
;
Bone Regeneration*
;
Capillaries
;
Carthamus tinctorius*
;
Medicine, East Asian Traditional
;
Osteogenesis
;
Periodontal Diseases
;
Rats*
;
Regeneration
8.Metastatic Adenocarcinoma of Optic Nerve: A Case Report.
Jin Yong KIM ; Sang Keun PARK ; Han Sung KIM ; Hyung Shik SHIN ; Yong Soon HWANG ; Sang Jin KIM
Journal of Korean Neurosurgical Society 2000;29(8):1069-1073
No abstract available.
Adenocarcinoma*
;
Optic Nerve*
9.Clinical Significance of Bifrontotemporal Decompressive Craniectomy in the Treatment of Severe Refractory Posttraumatic Brain Swelling.
Hyung Shik SHIN ; Jin Yong KIM ; Tae Hong KIM ; Yong Soon HWANG ; Sang Jin KIM ; Sang Keun PARK
Journal of Korean Neurosurgical Society 2000;29(9):1179-1183
No abstract available.
Brain Edema*
;
Brain*
;
Decompressive Craniectomy*
10.The Effects of Transforming Growth Factor beta1 on Apoptosis in Rat Hepatocellular Carcinoma.
Young Euy PARK ; Young Hee CHOI ; Won Yo LEE ; Jin Ja PARK ; Kyung Chan CHOI ; Hyung Shik SHIN
Korean Journal of Pathology 1999;33(2):71-79
Based upon the concept that carcinogenesis is associated with apoptosis, specific therapies designed to enhance the susceptibility of cancer cells to undergo apoptosis could be developed. Thus, in this paper, it was designed to investigate whether, using rat animal model with chemical-induced hepatocellular carcinoma, TGF-1 in vivo could induce apoptosis in cancer. The chemical hepatocarcinogenic procedure of Solt-Farber method was used on Sprague-Dawley rats. Experimental groups were divided into group A treated with the standard Solt-Farber regimen of diethylnitrosamine (DEN) and 2-Acetaminofluorene (AAF), group B TGF-, group C TGF-1, and group D adriamycin after hepatocellular carcinoma developed. For detection of apoptotic cells, apoptotic indices were examined by the in situ end DNA labelling method. The expression of proliferating cell nuclear antigen was examined by immunohistochemical staining. Apoptosis of rat hepatocellular carcinoma cells increased significantly to 4.92+/-2.32/HPF in the group C compared with the control group (A) (2.54+/-1.13/HPF; P<0.05). Two distinctly different populations of proliferating hepatocellular carcinoma cells were identified. The cells at G1/S boundary (weak granular staining) increased to 15.75+/-6.19/HPF and 6.45+/-2.93/HPF in the groups C and D, respectively, but decreased to 2.42+/-2.06/HPF in the group B compared with the control group (A) (6.38+/-2.18/HPF; p<0.05). The cells at S phase (strong granular staining) increased to 3.37+/-2.69/HPF in the group B but decreased to 0.32+/-0.47/HPF in the group D (p<0.05). In conclusion, these results indicate that the TGF-1 may be used as an effective anticancer agent.
Animals
;
Apoptosis
;
Carcinogenesis
;
Carcinoma, Hepatocellular*
;
Diethylnitrosamine
;
DNA
;
Doxorubicin
;
Models, Animal
;
Proliferating Cell Nuclear Antigen
;
Rats*
;
Rats, Sprague-Dawley
;
S Phase
;
Transforming Growth Factor alpha
;
Transforming Growth Factor beta1*
;
Transforming Growth Factors*