1.The Endocrine Manifestations and Growth of the Patients with 22q11.2 Microdeletion Syndrome.
Jong Seung LEE ; Jin Ho CHOI ; Han Wook YOO
Journal of Korean Society of Pediatric Endocrinology 2004;9(1):66-71
PURPOSE:Varying clinical phenotypes are associated with the chromosome 22q11.2 microdeletion syndrome. The endocrine manifestation are latent or overt hypoparathyroidism, thyroid dysfunction and short stature. This study was undertaken to investigate frequencies of endocrine abnormalities and short stature in patients with the chromosome 22q11.2 microdeletion syndrome. METHODS:Forty three unrelated patients were diagnosed having chromosome 22q11.2 microdeletion syndrome. Chromosomal microdeletion was confirmed by fluorescent in situ hybridation (FISH) with DNA probe (22q11.2 LSI TUPLE1 from Vysis). Serum total calcium and intact parathyroid hormone (PTH) were measured in all patients. Thyroid function tests including free thyroxine(T4), thyroid stimulating hormone (TSH) and thyroid autoantibodies were performed in all patients. Insulin-like growth factor-1 (IGF-1) was measured in 10 patients. Height, weight and body mass index were compared with chronological age in all patients. RESULTS:Seven patients (16%) had an overt hypoparathyroidism, presenting with hypocalcemic tetany. Thirteen patients (31%) showing hypocalcemia with normal PTH were regarded as having latent hypoparathyroidism since their PTH secretion response was blunted. Out of 2 patients with thyroid diseases, one patient had Graves disease and the other had Hashimoto thyroiditis. Five patients (12%) were below the 3rd percentile in height at evaluation. The BMI was below the 5th percentile in 23% of patients. CONCLUSION: Twenty patients (47%) presented with overt and latent hypoparathyroidism. Interestingly, autoimmune thyroid diseases such as Graves disease and Hashimoto thyroiditis were associated in patients with chromosome 22q11.2 microdeletion, indicating predisposition to autoimmune disorders. Therefore, a careful endocrine and growth evaluation is needed in these patients.
Autoantibodies
;
Body Mass Index
;
Calcium
;
DNA
;
Graves Disease
;
Hashimoto Disease
;
Humans
;
Hypocalcemia
;
Hypoparathyroidism
;
Parathyroid Hormone
;
Phenotype
;
Tetany
;
Thyroid Diseases
;
Thyroid Function Tests
;
Thyroid Gland
;
Thyrotropin
2.A clinical review of peripheral arterial aneurysm.
Whi Nam CHOI ; Seung Jin YOO ; Yong Bok KOH
Journal of the Korean Surgical Society 1991;41(3):380-390
No abstract available.
Aneurysm*
3.A-V fistula after Palma-Dale crossover venous graft operation in iliac vein occlusion
Sang Seob YOON ; Seung Jin YOO ; Yong Bok KOH
Journal of the Korean Society for Vascular Surgery 1991;7(1):102-107
No abstract available.
Fistula
;
Iliac Vein
;
Transplants
4.The Primary Repair of Acute Anterior Cruciate Ligament Injury
Jin Hwan AHN ; Myung Chul YOO ; Seung Gyun CHA ; Se Jin KUM
The Journal of the Korean Orthopaedic Association 1987;22(1):151-158
The acute anterior cruciate ligament injury is one of the most common ligament injury of the knee joint and there are many controversies in its treatment. Warren reported that the primary repair for the acute anterior cruciate ligament injuries was good, but some had opposite oppinions. Authors studied 23 patients of actue anterior cruciate ligament injury who were treated by primary repair from January, 1982 to December, 1984. The results were as followings: 1. The most common associated injury was MCL injury and posteromedial capsular injury(13 cases; 56.5%). 2. The most common detachment site of ACL was femoral attachment(11 cases; 47.8%) . 3. A medial Hocky Stick incision was found good in repairing the combined MCL and posteromedial capsular tear with ACL injury. 4. The results were good in 74% by Cincinnati score and in 87% by objective score. It is concluded that primary repair of the acute anterior cruciate ligament tear is cosidered successful.
Anterior Cruciate Ligament
;
Humans
;
Knee Joint
;
Ligaments
;
Tears
5.Therapeutic Outcome and Prognosis in Dlderly Patients with Non - Hodgkin's Lymphoma.
Jee Sook HAHN ; Jin Hyuk CHOI ; Seung Tae LEE ; Yoo Hong MIN ; Yun Woong KO
Journal of the Korean Cancer Association 1999;31(2):320-330
PURPOSE: The prognosis of non-Hodgkins lymphoma (NHL) in elderly patients seems to be poorer than that in patients aged less than 60 years. This may be due to the lower tolerance for combination chemotherapy in the elderly. Aggressive combination chemo-therapy, which is the treatment of choice in intermediate and high grade NHL of adulthood, may be associated with unpredictab1y severe and lethal toxicity and worsened quality of life in the elderly. We investigated the treatment responses, toxicities and prognostic factors of NHL in elderly patients treated with combination chemotherapy. MATERIALS AND METHODS: We treated 116 elderly (>60 yrs) patients with NHL between January 1986 and June 1996 with adriamycin-containing regimens, such as CHOP (cyclo- phosphamide, adriamycin, vincristine, prednisolone), BACOP (bleomycin, adriamycin, cyclophosphamide, vincristine, prednisolone), and mBACOP (methotrexate, bleomycin, adriamycin, cyclophosphamide, vincristine, prednisolone). Patients in this study ranged from 60 to 81 (median 67) years of age. Fifty-five percent of patients were in stage I or II and the rest (45%) were in stage III or IV. The histologic grade was predominantly (91%) of intermediate and high grade type. RESULTS: The treatment responses were complete (CR) in 55% and partial (PR) in 25%. The median durstion of CR was 32 (3-132) months. The CR rate was significantly higher in patients treated with RDI (relative dose intensity) > 75% than that in the patients treated with RDI < 75% (p 0.003), but there was no significant difference in CR rate between treatment regimens (p-0.38). At a median follow up of 48-months (range, 12 to 132 months), the estimated 5-year ovetall survival was 46%. Ann Arbor Stage (I, II vs III, IV), ECOG performance (0-1 vs 2-3), RDI (>75% vs <75%) and the treatment response were important prognostic factors in the univariate analysis, and the treament response (CR vs non-CR) was the only independent prognostic parameter in the multivariate analysis. The most frequent and severe toxicity associated with chemotherapy was infection with or without neutropenia. The rate of severe infection was significantly decreased in the patients supported with G/GM-CSF but not in the dose-reduction group (RDI<75% vs >75%). CONCLUSION: Our data suggests that achievement of the CR after combination chemotherpy is the most important prognostic factor in the elderly patients with NHL. Suboptimal chemotherapy (RDI<75%) reduced the complete remission rate without reducing the likelihood of developing severe toxicities. Optimal chemotherapy with supportive cares involving the use of hematopoietic growth factors may be needed to improve the treatment response and the survival in the elderly patients with aggressive NHL.
Aged
;
Bleomycin
;
Cyclophosphamide
;
Dimethoate
;
Doxorubicin
;
Drug Therapy
;
Drug Therapy, Combination
;
Follow-Up Studies
;
Hodgkin Disease*
;
Humans
;
Intercellular Signaling Peptides and Proteins
;
Lymphoma, Non-Hodgkin
;
Multivariate Analysis
;
Neutropenia
;
Prognosis*
;
Quality of Life
;
Vincristine
6.Two Cases of Endometriosis in the Episiotomy Scar Following Vaginal Delivery.
Mee Jeong YOO ; Seung Ho HAH ; Yoon Jin JEONG ; Kyu Hong CHOI
Korean Journal of Obstetrics and Gynecology 1997;40(10):2340-2343
Endometriosis in the episiotomy scar following vaginal delivery is one of the very rare condition among the extrapelvic endometriosis. We have experienced two cases of endometriosis in the episiotomy scar following vaginal delivery. We report two cases with a brief review of the concerned literatures.
Cicatrix*
;
Endometriosis*
;
Episiotomy*
;
Female
7.The Risk Factors of Clostridium difficile Colitis in Colorectal Surgery.
Journal of the Korean Society of Coloproctology 2010;26(5):307-308
No abstract available.
Clostridium
;
Clostridium difficile
;
Colitis
;
Colorectal Surgery
;
Risk Factors
8.A Case of Congenital Triangular Alopecia.
Hyoung Cheol YOO ; Seong Jin KIM ; Seung Chul LEE ; Young Ho WON
Korean Journal of Dermatology 2000;38(5):710-711
No Abstract Available.
Alopecia*
9.A Case of Clear Cell Sarcoma of the Anterior Chest.
Sang Hak LEE ; Jin Ho CHO ; Seung Min HONG ; Byung Mun CHOI ; Yoo Shin LEE
Korean Journal of Dermatology 1989;27(4):477-480
Clear cell sarcoma of tendon and aponeurosis is a rare malignant tumor. It occurs chiefly in young adults, predominates in women and is most common in the regions of the foot and ankle. We report a case of clear cell sarcoma of tendon and aponeurosis in s 22-year-old man. he pstient had had a asymptomatic, normal skin colored, relativerly hard, dome shsped nodule on the anterior chest for 6 months. Histopsthologic findings revealed uniform pattern composed of compact nests of round or fusiform cells which had clear cytoplasm and were surrounded by delicate framework of fibrocollagenous tissue, and the individual tumor cell had a fairly regular appearance of possessing round to avoid vesicular nucleus with prominent basophilic nucleolus. One year after surgical excision and post operative radiotherapy, there was no recurrence.
Ankle
;
Basophils
;
Cytoplasm
;
Female
;
Foot
;
Humans
;
Radiotherapy
;
Recurrence
;
Sarcoma, Clear Cell*
;
Skin
;
Tendons
;
Thorax*
;
Young Adult
10.A case of thanatophoric dysplasia.
Bum Seung PARK ; So Mi YOO ; Tae Woong KIM ; Young Kwan SHIN ; Dong Jin KIM
Korean Journal of Obstetrics and Gynecology 1993;36(7):2383-2388
No abstract available.
Thanatophoric Dysplasia*