Interferon regulatory factor 5 (IRF-5) can induce the expressions of IFN-α,IFN-β and promote the secretion of cytokines,including IL-6,IL-12 b,IL-17,IL-23,TNF etc.IRF-5 is involved in the process of immune response,cell growth,cell differentiation,cell apoptosis,tumorigenesis and cell signal transduction.For that reason,IRF-5 plays an important role in the occurrence and progress of many diseases in humans.Further studies of IRF-5 will better elucidate the pathogenesis of related diseases and provide theoretical basis for treatment of these diseases and the corresponding therapeutic targets.

Objective: To simultaneously detect five components (phillyrin, chlorogenic acid, chlorpheniramine maleate, vitamin C and acetaminophen) in compound paracetamol vitamin C Yinqiao tablets.Methods: Using a Waters Xselect C18 column(250 mm×4.6 mm, 5 μm), the mobile phase consisted of acetonitril-0.1 mol·L-1 NaH2PO4(pH 3.0) with gradient elution at a flow rate of 1.0 ml·min-1.The detection wavelength was 230 nm and the column temperature was 35℃.Results: The linear range of vitamin C, acetaminophen, chlorogenic acid, chlorphenamine maleate and phillyrin was 0.500-200.200, 0.499-199.600, 0.501-200.100, 0.502-200.900 and 0.488-195.400 μg·ml-1(r＞0.999), respectively.The average recovery was 99.3%(RSD=1.5%), 97.8%(RSD=1.7%), 98.5%(RSD=1.1%), 97.1%(RSD=1.7%)and 99.8%(RSD=1.2%)(n=9), respectively.Conclusion: The simple and sensitive method can be applied in the quality control of compound paracetamol vitamin C Yinqiao tablets.

Aged ; Animals ; Climacteric ; drug effects ; Disease Models, Animal ; Drug Therapy, Combination ; Drugs, Chinese Herbal ; therapeutic use ; Female ; Humans ; Integrative Medicine ; methods ; Middle Aged ; Perimenopause ; Periodontitis ; drug therapy ; Phytotherapy ; Rats ; Rats, Sprague-Dawley

Objective To evaluate the relevance between transthoracic echocardiography(TTE)and cardiac catheterization in measuring diameter of patent ductus arteriosus(PDA)and assessing pulmonary artery pressure.Methods The diameter of PDA and the pulmonary artery pressure in 105 patients were observed by TTE and cardiac catheterization,respectively.Results The di-ameter of the narrowest segment of the ductus and pulmonary artery pressure measurements by TTE and cardiac catheterization showed excellent correlation(r=0.782,P<0.01;r=0.810,P<0.01,respectively).Conclusion TTE and cardiac catheterization for measuring diameter of PDA and pulmonary artery pressure show excellent correlation.TTE plays an important role in evaluating pulmonary artery pressure and selecting patients efficiency of PDA occlusion.

OBJECTIVE:To observe therapeutic efficacy of Xinyi biyan pills combined with budilaide in the treatment of aller-gic rhinitis and its effects on related inflammatory factors. METHODS:A total od 120 patients with allergic rhinitis were randomly divided into observation group and control group,with 60 cases in each group. Control group was treated with Budesonide nasal spray,spraying once each nostril(64 μg/spray),2 times a day. Observation group was additionally treated with Xinyi biyan pills 3 g,3 times a day. Treatment course lasted for 4 weeks. Clinical efficacies of 2 groups were observed and compared. The changes of total score of clinical symptoms and signs were observed before and after treatment. The contents of IgE and LTE4 were deter-mined,and the occurrence of ADR was recorded. RESULTS:Three patients of observation group and 4 patients of control group fell of the study. Total response rate of observation group was significantly higher than that of control group,with statistical signifi-cance (84.21% vs. 73.21%,P<0.05). Before treatment,there was no statistical significance in total score of clinical symptoms and signs,IgE and LTE4 levels between 2 groups (P>0.05). After 2 and 4 weeks of treatment,total score of clinical symptoms and signs,IgE and LTE4 levels in 2 groups were significantly lower than before treatment,and the observation group was signifi-cantly lower than control group,with statistical significance (P<0.05). No obvious ADR was found in 2 groups. CONCLU-SIONS:Xinyi biyan pills combined with budesonide show good therapeutic efficacy for allergic rhinitis,improve clinical symp-toms and signs significantly and reduce inflammatory factors levels with good safety.

Acupuncture Therapy ; Adult ; Aged ; Aged, 80 and over ; Combined Modality Therapy ; Exercise Therapy ; Female ; Humans ; Male ; Middle Aged ; Osteoarthritis, Knee ; therapy ; Treatment Outcome

Objective To explore the adverse effects of formaldehyde(FA)on learning and memory ability of mice and the antagonistic effect of N-acetyl-cysteine(NAC),an antioxidant.Methods Thirty-four ICR mice were randomly divided into four groups,the control(NS,n=8),treated with FA(15 mg/kg,n=9),treated with NAC(100 mg/kg,n=8),treated with FA(15 mg/kg) plus NAC(100 mg/kg,n=9),the treatment was conducted by intraperitoneal injection once a day for seven consecutive days.On the eighth day,the learning and memory ability were tested by using water labyrinth task for seven consecutive days.Results The mice in FA group behaved excited,restless and then turned to repose,moveless and clustering,but this phenomena was not seen in the other groups.There was no significant difference in the body weight of mice among groups.As for learning,latent period in the FA group [(27.15?2.66)s] was significantly longer than that in the control group [(15.83?2.82)s] and the FA+ NAC group[(14.98?2.66)s],and revealed statistical significance(P

Objective To discuss the prevention and treatment for complications following laparoscopic cholecystectomy (LC). Methods A total of 902 cases were summarized retrospectively with regard to causes, prevention and treatment of complications following LC. Results Out of the 902 cases, there were 2 cases of bile duct injury, 2 cases of residual calculi of common bile duct, and 4 cases of scrotum emphysema. The bile duct injury and residual calculi were all cured by re-operation, while the scrotum emphysema dissolved of itself without medical treatment. A conversion to open surgery was required in 31 cases. All the cases in the study were cured. Conclusions Emphasis should be laid on the prevention of complications after LC. A prompt conversion to open cholecystectomy is the key to the lowering of complication rate.

Objective The aim of this study is to compare the gains accomplished from different tympanoplasty based upon a review of patient records.Methods The charts of 137 patients who underwent different tympanoplasty operations were reviewed.They were divided into three groups.Group I,26 cases(26 ears) of tympanoplasty with mastoidectomy;group II,61 cases(62 ears) of tympanoplasty with mastoidectomy;group III,48 cases(49 ears) of myringoplasty.The hearing outcomes after dry ear were analyzed.Nonparametric statistics was used to determine group differences.A probability value of P

Objective To know the influence of psychological intervention on delivery results of par-turient women, and then reference to certain effective psychological nursing cares for clinical field. Methods Divided 226 partreient women of spontaneous labor into the experimental group and the control group randomly, there were 113 eases in each group. Traditional routine nursing cares was used in the control group, psychological intervention was used in the experimental group in addition. Compared the condi-tion of birth process and the incidence rate of labor-related complications between the two groups. Re-sults There were significant differences between the two groups about all the indexes which had indicated the delivery. Conclusions Correct psychoanalysis and proper nursing intervention and effective release the pains for parturient women, and then decrease the incidence rate of medical negligence.