In order to examine the properties of catecholic receptor-mediated activation of Na-K-ATPase reaction, author have studied. 1) the structure-activity relationships of various catechol analogues as stimulants of rat cortical Na-K-ATPase. 2) the stereospecificity of alpha and beta-adrenergic agonists on their activation of enzyme system and 3) the relationship of the receptive sites to the enzyme Na-K-ATPase and the effect of EDTA. The observed results were as follows: 1) Noradrenalin, dopamine and isoproterenol stimulated the Na-K-ATPase activity in rat cortical nomogenate. 2) The Na-K-ATPase activation elicited by catecholamines could not be antagonized by beta-receptor blocker, phentolamine and alpha-receptor blocker, propranolol decreased the increase in activity evoked by catecholamine, but it could not inhibit completely. 3) alpha-receptor blocker, phenoxybenzamine inhibited the noradrenalin activation on Na-K-ATPase, and decreased the effect of EDTA on the Na-K-ATPase activity.
Adrenergic Agonists ; Adrenergic beta-Agonists ; Animals ; Brain* ; Catecholamines ; Dopamine ; Edetic Acid ; Isoproterenol ; Phenoxybenzamine ; Phentolamine ; Propranolol ; Rats ; Structure-Activity Relationship

Intracranial angiolipoma is extremely rare. We report the radiologic findings of angiolipoma in the rightmiddle cranial fossa, extending medially into the suprasellar and cavernous sinus region, in a 63-year-old woman.The lesion was a relatively well marginated extra-axial tumor that showed low density on precontrast CT and markedenhancement after contrast infusion. MR imaging showed heterogeneous low signal on T1W1 mixed with hyperintensefoci on T2W1, and marked enhancement after gadolinium infusion. On cerebral angiography, displacement of the rightinternal carotid artery by the tumor was seen. On an arteriogram of the right external carotid artery, the massshowed persistent capillary blush.
Angiolipoma* ; Capillaries ; Carotid Arteries ; Carotid Artery, External ; Cavernous Sinus ; Cerebral Angiography ; Gadolinium ; Humans ; Magnetic Resonance Imaging ; Middle Aged