No abstract available.

No abstract available.
Rubinstein-Taybi Syndrome*

OBJECTIVES: This study was to investigate the prevalence of cognitive impairment and depressive symptoms among the elderly in an urban community. METHODS: Korean version of Mini-Mental State Examination(MMSE-K), Short version of Geriatric Depression Scale(SGDS), and the Center for Epidemiologic Studies Depression(CES-D) were administered to 447 elderly persons(37.7% of all residents aged 65 and older) who resided in "Sanggye 10 Dong" by lay interviewers. Then a Psychiatrist and two Psychiatric residents interviewed the elderly scoring 23 or less on MMSE-K and diagnosed with dementia according to the criteria of DSM-III-R. RESULTS: The prevalence of cognitive impairment was estimated as 37.1%(male 18.8%, female 47.0%) by MMSE-Kor=25 and 15.8% by SGDS>or=10. Prevalences(CES-D>or=25) for the age groups 65 to 69, 70 to 74, 75 to 79, 80 to 84, and over 85 were, respectively 15.7%, 18.1%, 23.4%, 13.3%, and 23.5%. Caseness of depressive symptoms(CES-D >or= 25) was not related to sex, age, years of education, marital status, physical illness, occupation, living condition, and financial status. Of 166 persons who had cognitive impairment(MMSE-K Aged* ; Dementia ; Depression* ; Education ; Epidemiologic Studies ; Female ; Humans ; Marital Status ; Occupations ; Prevalence* ; Psychiatry ; Social Conditions

Authors reviewed 1809 childhood accident cases who visited the emergency room of Soon Chun hyung Hospital from May, 1974 to Aug. 1980. The following results were obtained; 1. Incidence of accidents was 4.1% of all patients who visited emergency room. 2. The highest age incidence was in the age group of 5-9 years, especially in Falldown, Traffic accident, Laceration accident. But Burn, Poisoning and Foreign body accidents were most frequent in the age group of 1-4 years. 3. Male to Female ratio was 1.74:1 4. Seasonal Distibution showed high incidence in Spring and Summer. 5. Accidents were happenedmostly at 4:00 PM - 8:00 PM 6. Causes of Accidents were Falldown(28.3%), Traffic accident (22.4%), Laceration(22.0%), Burn(9.5%), Poisoning (7.5%), Foreign body(4.0%), and Others(3.1%), listed in decreasing order of frequency. 7. Head was the part of the body most frequently involved in Fallodwn, Traffic accident and Laceration accidents. 8. Mortality rate was 7.2% of all accidents and traffic accident was the most common cause of death. Mortality was highest in the age group of 1-4 years.
Accidents, Traffic ; Burns ; Cause of Death ; Emergency Service, Hospital ; Female ; Foreign Bodies ; Head ; Humans ; Incidence ; Lacerations ; Male ; Mortality ; Poisoning ; Seasons ; Statistics as Topic*

A statistical study on 135 cases of acute poisoning who were treated in Pediatric department of Soon Chun Hyang College Hospital from May, 1974 to August, 1980 was performed. The results are as follows: 1. Seasonal incidence was more prevalent in summer. (from June to August, Table 2) 2. It occurred more frequently in male than female and high incidence was noted in 1 to 3 year-old age group(Table 5). 3. The causative chemicals were found to be 58 kinds & the commonest chemical was insecticides which were 16.3% of all cases. Rodenticides and tranquilizers(11.9%), D.D.S. (5.1%), kerosence(3.7%) were the next common causatvie agents. And drugs were more frequent than non-drug agents(Table. 3). 4. Accidental poisoning was more frequent than therapeutic and suididal purpose(Table 6). 5. It occurred most frequently during 3 to 6 O'lock in the afternoon and especially from 6 to 9 O'lock in morning and in the evening in the 0 to 1 year-old age. 6. There were complications which were aspiration pneumonia(3 cases). Corrosive pharyngitis (1 cases) and anoxic brain damage(1 cases) respectively. And death occurred in 1 cases due to insecticide.
Brain ; Child* ; Child, Preschool ; Female ; Humans ; Incidence ; Insecticides ; Male ; Pharyngitis ; Poisoning ; Rodenticides ; Seasons ; Statistics as Topic*

The 15 year-old female patient was admitted with the complaints of moon face, obesity and short stature. She has received steroid therapy since 11 years ago at home to control joint pain due to rheumatoid arthritis. The diagnosis was confirmed by history of long-term steroid therapy, characteristic clinical features, biochemical studies and radiological studies. In radiological studies, superior mediastinal widening, aseptic necrosis of both hip an diffuse osteoporosis in various skeleton were revealed. Brief review of literature was presented.
Adolescent ; Arthralgia ; Arthritis, Rheumatoid ; Diagnosis ; Female ; Hip Joint* ; Hip* ; Humans ; Lipomatosis* ; Necrosis* ; Obesity ; Osteoporosis ; Skeleton

OBJECTIVES: This study aimed to develop an informant report questionnaire for dementia screening and to verify its reliability and validity. METHODS: A preliminary questionnaire with 30 items was administered to a reliable informant for each of 81 dementia patients and 166 normal controls. Through item analyses, the 15-item Seoul Informant Report Questionnaire for Dementia (SIRQD) was clraum up. Internal consistency and inter-informant correlation were analyzed. Factor analysis and ROC curve analysis were also performed. RESULTS: SIRQD was found to have high internal consistency and inter-informant reliability. Optimal cut-off score of SIRQD was 9/10, and the sensitivity and specificity at that score were .850 and .873, respectively. SIRQD was composed of four major factors (remote memory, recent memory, language, and activity of daily living). SIRQD was closely equivalent to MMSE-KC in terms of overall dementia screening ability, and it appeared efficient in discriminating very mild dementia from normal. SIRQD showed low false positive and negative rates, irrespective of levels of education, age, and sex. CONCLUSION: SIRQD possess good psychometrical properties and is probably very useful to screen dementia, especially for the Korean elderly with a very wide range of educational background.
Aged ; Dementia* ; Education ; Humans ; Mass Screening* ; Memory ; Surveys and Questionnaires* ; Reproducibility of Results ; ROC Curve ; Sensitivity and Specificity ; Seoul*

OBJECTIVE: We investigated neuropsychological markers that can be used to discriminate pathological cognitive aging from normal cognitive aging. METHODS: We administered frontal lobe function tests including the Wisconsin Card Sorting Test (WCST), digit span test, lexical fluency test, fixed condition design fluency test, and Trail Making Test B (TMT-B) to 92 individuals with pathological cognitive aging (PCA) and 222 individuals with normal cognitive aging (NCA). We examined the main effects of participants' diagnoses (PCA, NCA) and age (65-69 years old, 70-74 years old and 75 years old or over) on their test performance using multivariate analysis of variance. RESULTS: The main effects of both the diagnosis (F=2.860, p=0.002) and the age group (F=2.484, p<0.001) were significant. The PCA group showed lower performance on the backward digit span test (F=14.306, p<0.001), fixed condition design fluency test (F=8.347, p=0.004) and also exhibited perseverative errors in the WCST (F=4.19, p=0.042) compared with the NCA group. The main effect of the diagnosis on the backward digit span test and the fixed condition design fluency test remained significant after Bonferroni correction. The main effect of age remained significant in the TMT-B (F=8.737, p<0.001) after Bonferroni correction. Other test scores were not influenced by diagnosis or age. CONCLUSION: The design fluency task may be a good neuropsychological marker to assess pathological cognitive aging.
Aging ; Frontal Lobe ; Humans ; Longitudinal Studies ; Mild Cognitive Impairment ; Multivariate Analysis ; Passive Cutaneous Anaphylaxis ; Trail Making Test ; Wisconsin

Objective: To investigate the relationship between reduced glutathione (GSH), a key molecule of the antioxidant defense system in the blood, and glutathione reductase (GR), which reduces oxidized glutathione (glutathione disulfide [GSSG]) to GSH and maintains the redox balance, with the prevalence of Alzheimer’s dementia and cognitive decline. Methods: In all, 20 participants with Alzheimer’s dementia who completed the third follow-up clinical evaluation over 6 years were selected, and 20 participants with normal cognition were selected after age and sex matching. The GSH and GR concentrations were the independent variables. Clinical diagnosis and neurocognitive test scores were the dependent variables indicating cognitive status. Results: The higher the level of GR, the greater the possibility of having normal cognition than of developing Alzheimer’s dementia. Additionally, the higher the level of GR, the higher the neurocognitive test scores. However, this association was not significant for GSH. After 6 years, the conversion rate from normal cognition to cognitive impairment was significantly higher in the lower 50th percentile of the GR group than in the upper 50th percentile. Conclusion The higher the GR, the lower the prevalence of Alzheimer’s dementia and incidence of cognitive impairment and the higher the cognitive test scores. Therefore, GR is a potential protective biomarker against Alzheimer’s dementia and cognitive decline.